Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment

2020 ◽  
Vol 8 (27) ◽  
pp. 5793-5807
Author(s):  
Jinping Shi ◽  
Juan Li ◽  
Yan Wang ◽  
Jingjing Cheng ◽  
Can Yang Zhang
Keyword(s):  
Infectious Disease ◽  
Side Effects ◽  
Therapeutic Efficacy ◽  
Photothermal Therapy ◽  
Disease Treatment ◽  
Recent Advances

MoS2-based PTT with high therapeutic efficacy and minimal side-effects could show potential for improving cancer and infectious disease treatments.

Recent advances in nanomaterials for enhanced photothermal therapy of tumors

Nanoscale ◽  
2018 ◽  
Vol 10 (48) ◽  
pp. 22657-22672 ◽  
Author(s):  
Jing-Jing Hu ◽  
Ying-Jia Cheng ◽  
Xian-Zheng Zhang
Keyword(s):  
Therapeutic Efficacy ◽  
Photothermal Therapy ◽  
Tumor Treatment ◽  
Recent Advances

Recent advances in nanomaterials for enhanced therapeutic efficacy of photothermal therapy in tumor treatment were highlighted.

Dual-modal imaging-guided highly efficient photothermal therapy using heptamethine cyanine-conjugated hyaluronic acid micelles

2017 ◽  
Vol 5 (6) ◽  
pp. 1122-1129 ◽  
Author(s):  
Sanpeng Li ◽  
Zhihong Sun ◽  
Guanjun Deng ◽  
Xiaoqing Meng ◽  
Wenjun Li ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Side Effects ◽  
Therapeutic Efficacy ◽  
Photothermal Therapy ◽  
Highly Efficient ◽  
Size Stability

Targeted phototherapy and multi-modal imaging can effectively improve the therapeutic efficacy and reduce the side effects of theranostics. (A) Synthesis of the HA-IR808. (B) Diameters and morphology of HAIR NPs measured by DLS and TEM. (C) Size stability of HAIR NPs.

scholarly journals Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 837 ◽  
Author(s):  
Shi Su ◽  
Peter M. Kang
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Surface Stabilization ◽  
Recent Advances

Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

scholarly journals Precision Photothermal Therapy and Photoacoustic Imaging by In Situ Activatable Thermoplasmonics

2021 ◽  
Author(s):  
Yahua Liu ◽  
Fengye Mo ◽  
Jialing Hu ◽  
Qunying Jiang ◽  
Xiuyuan Wang ◽  
...  
Keyword(s):  
Side Effects ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Clinical Translation ◽  
Great Promise ◽  
Disease Treatment ◽  
Normal Tissues

Phototherapy holds great promise for disease treatment; however, traditional “always-on” photoagents have been restricted for clinical translation due to nonspecific response and side effects on normal tissues. Here, we show...

Recent Advances in the Synthesis and Development of Nitroaromatics as Anti-Infective Drugs

2020 ◽  
Vol 26 (36) ◽  
pp. 4658-4674 ◽  
Author(s):  
Christina Kannigadu ◽  
David. D. N'Da
Keyword(s):  
Infectious Disease ◽  
Drug Resistance ◽  
Chest Pain ◽  
Muscle Pain ◽  
New Drugs ◽  
Lymph Glands ◽  
Recent Advances ◽  
Personality Changes ◽  
Clinical Drugs ◽  
Antiparasitic Agents

: Infectious diseases commonly occur in tropical and sub-tropical countries. The pathogens of such diseases are able to multiply in human hosts, warranting their continual survival. Infections that are commonplace include malaria, chagas, trypanosomiasis, giardiasis, amoebiasis, toxoplasmosis and leishmaniasis. Malaria is known to cause symptoms, such as high fever, chills, nausea and vomiting, whereas chagas disease causes enlarged lymph glands, muscle pain, swelling and chest pain. People suffering from African trypanosomiasis may experience severe headaches, irritability, extreme fatigue and swollen lymph nodes. As an infectious disease progresses, the human host may also experience personality changes and neurologic problems. If left untreated, most of these diseases can lead to death. : Parasites, microbes and bacteria are increasingly adapting and generating strains that are resistant to current clinical drugs. Drug resistance creates an urgency for the development of new drugs to treat these infections. Nitro containing drugs, such as chloramphenicol, metronidazole, tinidazole and secnidazole had been banned for use as antiparasitic agents due to their toxicity. However, recent discoveries of nitrocontaining anti-tuberculosis drugs, i.e. delamanid and pretonamid, and the repurposing of flexinidazole for use in combination with eflornithine for the treatment of human trypanosomiasis, have ignited interest in nitroaromatic scaffolds as viable sources of potential anti-infective agents. : This review highlights the differences between old and new nitration methodologies. It furthermore offers insights into recent advances in the development of nitroaromatics as anti-infective drugs.

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

The Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib

2020 ◽  
Vol 20 (6) ◽  
pp. 700-708
Author(s):  
Mitra Korani ◽  
Sara Nikoofal-Sahlabadi ◽  
Amin R. Nikpoor ◽  
Solmaz Ghaffari ◽  
Hossein Attar ◽  
...  
Keyword(s):  
Side Effects ◽  
Cell Line ◽  
Therapeutic Efficacy ◽  
Drug Loading ◽  
Particle Diameter ◽  
In Vitro Cytotoxicity ◽  
Liposomal Formulations ◽  
Cytotoxicity Studies ◽  
Anti Tumor Activity

Aims: Here, three liposomal formulations of DPPC/DPPG/Chol/DSPE-mPEG2000 (F1), DPPC/DPPG/Chol (F2) and HSPC/DPPG/Chol/DSPE-mPEG2000 (F3) encapsulating BTZ were prepared and characterized in terms of their size, surface charge, drug loading, and release profile. Mannitol was used as a trapping agent to entrap the BTZ inside the liposomal core. The cytotoxicity and anti-tumor activity of formulations were investigated in vitro and in vivo in mice bearing tumor. Background: Bortezomib (BTZ) is an FDA approved proteasome inhibitor for the treatment of mantle cell lymphoma and multiple myeloma. The low solubility of BTZ has been responsible for the several side effects and low therapeutic efficacy of the drug. Encapsulating BTZ in a nano drug delivery system; helps overcome such issues. Among NDDSs, liposomes are promising diagnostic and therapeutic delivery vehicles in cancer treatment. Objective: Evaluating anti-tumor activity of bortezomib liposomal formulations. Methods: Data prompted us to design and develop three different liposomal formulations of BTZ based on Tm parameter, which determines liposomal stiffness. DPPC (Tm 41°C) and HSPC (Tm 55°C) lipids were chosen as variables associated with liposome rigidity. In vitro cytotoxicity assay was then carried out for the three designed liposomal formulations on C26 and B16F0, which are the colon and melanoma cancer mouse-cell lines, respectively. NIH 3T3 mouse embryonic fibroblast cell line was also used as a normal cell line. The therapeutic efficacy of these formulations was further assessed in mice tumor models. Result: MBTZ were successfully encapsulated into all the three liposomal formulations with a high entrapment efficacy of 60, 64, and 84% for F1, F2, and F3, respectively. The findings showed that liposomes mean particle diameter ranged from 103.4 to 146.8nm. In vitro cytotoxicity studies showed that liposomal-BTZ formulations had higher IC50 value in comparison to free BTZ. F2-liposomes with DPPC, having lower Tm of 41°C, showed much higher anti-tumor efficacy in mice models of C26 and B16F0 tumors compared to F3-HSPC liposomes with a Tm of 55°C. F2 formulation also enhanced mice survival compared with untreated groups, either in BALB/c or in C57BL/6 mice. Conclusion: Our findings indicated that F2-DPPC-liposomal formulations prepared with Tm close to body temperature seem to be effective in reducing the side effects and increasing the therapeutic efficacy of BTZ and merits further investigation.

Recent advances in the development of metal-organic framework-based gas nanoplatforms for synergistic cancer therapy

2021 ◽  
Author(s):  
Yong Yao ◽  
Danni Jing ◽  
Jianan Zhang ◽  
Youyou Huang ◽  
Xiru Qin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Metal Organic Framework ◽  
Research Field ◽  
Tumor Site ◽  
Recent Advances ◽  
Metal Organic ◽  
Organic Framework

Featuring high therapeutic efficacy, biocompatibility, and biosafety, gas therapy as a burgeoning and promising research field has attracted considerable attention in biomedicine. However, the lack of the tumor site accumulation...

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