Fabrication of an injectable BMSC-laden double network hydrogel based on silk fibroin/PEG for cartilage repair

2020 ◽  
Vol 8 (27) ◽  
pp. 5845-5848
Author(s):  
Yajie Zhang ◽  
Yi Cao ◽  
Liwei Zhang ◽  
Hongbo Zhao ◽  
Tianyu Ni ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Silk Fibroin ◽  
Cartilage Repair ◽  
Bioorthogonal Reaction ◽  
Double Network ◽  
Good Biocompatibility ◽  
Gelation Rate

A fast-forming BMSC-encapsulated DN hydrogel with a fast gelation rate, good biocompatibility and strong mechanical strength was fabricated via ultrasonically induced SF and bioorthogonal reaction crosslinking.

Inorganic/Organic Micro-Double-Network Ion Gel-Based Composite Membrane with Enhanced Mechanical Strength and CO2 Permeance

2021 ◽  
Author(s):  
Jinhui Zhang ◽  
Eiji Kamio ◽  
Masayuki Kinoshita ◽  
Atsushi Matsuoka ◽  
Keizo Nakagawa ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Composite Membrane ◽  
Double Network ◽  
Ion Gel

Secondary Structures and Mechanical Properties of Biomimetic Protein Polymers

2009 ◽  
Author(s):  
Weibing Teng ◽  
Joseph Cappello ◽  
Xiaoyi Wu
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Mechanical Behavior ◽  
Half Life ◽  
Secondary Structures ◽  
Load Bearing ◽  
Protein Polymers ◽  
Human Arteries ◽  
Good Biocompatibility ◽  
Polypeptide Sequences

Silk may possess superior mechanical strength while its resilience is very poor. In contrast, elastin in human arteries is very soft but extremely durable with an estimated half-life of 70 years. By combing polypeptide sequences derived from native silk and elastin, we have produced a series of silk-elastin-like proteins (SELPs), which have displayed a set of outstanding properties such as good biocompatibility and controllable biodegradation rates [1]. In this study, we will examine the crystallization of the silk-like blocks and the crosslinking of the elastin-like blocks, as well as their influences on the mechanical behavior of SELPs. The ultimate goal of this study is to explore the potential of SELPs for applications in the engineering of load-bearing tissues such as arteries.

scholarly journals Fabrication of Silk Fibroin/Graphene Film with High Electrical Conductivity and Humidity Sensitivity

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1774 ◽  
Author(s):  
Haoran Zhang ◽  
Juntao Zhao ◽  
Tieling Xing ◽  
Shenzhou Lu ◽  
Guoqiang Chen
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Wearable Sensors ◽  
Graphene Film ◽  
Natural Material ◽  
Casting Method ◽  
Good Biocompatibility ◽  
Minimum Resistance

Silk fibroin (SF) is a natural material with good biocompatibility and excellent mechanical properties, which are complementary to graphene with ultrahigh electrical conductivity. In this study, to maximally combine graphene and silk fibroin, a well-dispersed silk fibroin/graphene suspension was successfully prepared in a simple and effective way. Then we prepared a flexible conductive SF/graphene film with a minimum resistance of 72.1 ± 4.7 Ω/sq by the casting method. It was found that the electrical conductivity of the SF/graphene film was related to the water content of the film, and the variation was more than 200 times. Therefore, it will play an important role in the field of humidity sensors. It also has excellent mechanical properties in both wet and dry states. These unique features make this material a promising future in the fields of biomedical applications, wearable sensors, and implantable internal sensors.

Orthogonally Regulated Mechanical Strength and Molecular Delivery Capabilities Achieved in a Double Network Hydrogel Matrix

2020 ◽  
Vol 5 (19) ◽  
pp. 5781-5787
Author(s):  
Kaixuan Teng ◽  
Xinglong Luan ◽  
Qi An ◽  
Yantao Zhao ◽  
Xiantong Hu ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Double Network ◽  
Molecular Delivery ◽  
Hydrogel Matrix

A novel biocompatible double network hydrogel consisting of konjac glucomannan with high mechanical strength and ability to be freely shaped

2015 ◽  
Vol 3 (9) ◽  
pp. 1769-1778 ◽  
Author(s):  
Zhiyong Li ◽  
Yunlan Su ◽  
Baoquan Xie ◽  
Xianggui Liu ◽  
Xia Gao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Adhesion ◽  
Mechanical Strength ◽  
Synthetic Polymer ◽  
Natural Polymer ◽  
Tissue Engineering Scaffolds ◽  
Adhesion Properties ◽  
High Mechanical Strength ◽  
Double Network

A novel physically linked double-network (DN) hydrogel was prepared by natural polymer KGM and synthetic polymer PAAm. The DN hydrogels exhibit good mechanical properties, cell adhesion properties, and can be freely shaped, making such hydrogels promising for tissue engineering scaffolds.

scholarly journals Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

2020 ◽  
Vol 8 ◽  
Author(s):  
Li-Min Yu ◽  
Tao Liu ◽  
Yu-Long Ma ◽  
Feng Zhang ◽  
Yong-Can Huang ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Tissue Repair ◽  
Cellular Proliferation ◽  
Composite Scaffold ◽  
Bioactive Scaffolds ◽  
Cell Based Therapy ◽  
Nanofibrous Structure ◽  
Marrow Mesenchymal Stem Cells ◽  
Good Biocompatibility ◽  
The Mean

Interest is rapidly growing in the design and preparation of bioactive scaffolds, mimicking the biochemical composition and physical microstructure for tissue repair. In this study, a biomimetic biomaterial with nanofibrous architecture composed of silk fibroin and hyaluronic acid (HA) was prepared. Silk fibroin nanofiber was firstly assembled in water and then used as the nanostructural cue; after blending with hyaluronan (silk:HA = 10:1) and the process of freeze-drying, the resulting composite scaffolds exhibited a desirable 3D porous structure and specific nanofiber features. These scaffolds were very porous with the porosity up to 99%. The mean compressive modulus of silk-HA scaffolds with HA MW of 0.6, 1.6, and 2.6 × 106 Da was about 28.3, 30.2, and 29.8 kPa, respectively, all these values were much higher than that of pure silk scaffold (27.5 kPa). This scaffold showed good biocompatibility with bone marrow mesenchymal stem cells, and it enhanced the cellular proliferation significantly when compared with the plain silk fibroin. Collectively, the silk-hyaluronan composite scaffold with a nanofibrous structure and good biocompatibility was successfully prepared, which deserved further exploration as a biomimetic platform for mesenchymal stem cell-based therapy for tissue repair.

Double-Network Hydrogels with Extremely High Mechanical Strength

2003 ◽  
Vol 15 (14) ◽  
pp. 1155-1158 ◽  
Author(s):  
J.P. Gong ◽  
Y. Katsuyama ◽  
T. Kurokawa ◽  
Y. Osada
Keyword(s):  
Mechanical Strength ◽  
High Mechanical Strength ◽  
Double Network

Mechanical and In-Vitro Cell Compatibility Properties of Silk-Elastinlike Protein-Based Biomaterial

2010 ◽  
Author(s):  
Weibing Teng ◽  
Yiding Huang ◽  
Joseph Cappello ◽  
Xiaoyi Wu
Keyword(s):  
Mechanical Property ◽  
Cell Culture ◽  
Mechanical Strength ◽  
Genetically Engineered ◽  
Load Bearing ◽  
Cell Compatibility ◽  
Chemical Treatments ◽  
Good Biocompatibility ◽  
Physical And Chemical

A series of genetically engineered recombinant silk-elastinlike proteins (SELPs) have been produced by combining polypeptide sequences derived from native silk of superior mechanical strength and elastin that is extremely durable and resilient. They have displayed a set of outstanding properties such as good biocompatibility and controllable biodegradation rates. In the study, we characterized the mechanical property of genetically engineered, recombinant silk-elastinlike protein copolymer, SELP-47K, under physical and chemical treatments. The biocompatibility of the SELP-47K was also evaluated by cell culture. The ultimate goal of this study is to explore the potential of SELPs for applications in the engineering of load-bearing tissues such as arteries.

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