Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer

2020 ◽  
Vol 8 (38) ◽  
pp. 8781-8793
Author(s):  
Zhangfan Ding ◽  
Krishna Sigdel ◽  
Lei Yang ◽  
Yunfei Liu ◽  
Ming Xuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Cancer ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Diagnosis And Therapy ◽  
Life Threatening

Oral cancer is a common malignant life-threatening tumor.

A Triple-responsive Targeted Hybrid Liposomes with High MRI Performance for Tumor Diagnosis and Therapy

2021 ◽  
Author(s):  
Weihe Yao ◽  
Chenyu Liu ◽  
Ning Wang ◽  
Hengjun Zhou ◽  
Hailiang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Tumor Diagnosis ◽  
Diagnosis And Therapy ◽  
Promising Strategy ◽  
Therapy And Diagnosis

The targeted multi-responsive drug delivery systems with MRI capacity were anticipated as a promising strategy for tumor therapy and diagnosis. Herein, we successfully synthesized anisamide-modified and non-modified UV/GSH-responsive molecules (10,10-NB-S-S-P-AA...

Drug Delivery Systems‐Based Dendrimers and Polymer Micelles for Nuclear Diagnosis and Therapy

2021 ◽  
pp. 2000362
Author(s):  
Liliana Aranda‐Lara ◽  
Blanca Eli Ocampo García ◽  
Keila Isaac‐Olivé ◽  
Guillermina Ferro‐Flores ◽  
Laura Meléndez‐Alafort ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Polymer Micelles ◽  
Diagnosis And Therapy

scholarly journals Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

2014 ◽  
pp. 3719 ◽  
Author(s):  
Giovana Calixto ◽  
Bruno Fonseca-Santos ◽  
Marlus Chorilli ◽  
Jessica Bernegossi
Keyword(s):  
Drug Delivery ◽  
Oral Cancer ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 302 ◽  
Author(s):  
Ketabat ◽  
Pundir ◽  
Mohabatpour ◽  
Lobanova ◽  
Koutsopoulos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Alternative Methods ◽  
Therapeutic Approaches

Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.

Advanced drug delivery systems in oral cancer

2021 ◽  
pp. 235-242
Author(s):  
Subha Manoharan ◽  
Lakshmi Thangavelu ◽  
Kamal Dua ◽  
Dinesh Kumar Chellappan
Keyword(s):  
Drug Delivery ◽  
Oral Cancer ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Polymer based Drug Delivery Systems- benchtop to Bedside Transition

2021 ◽  
Vol 2 (2) ◽  
pp. 1-3
Author(s):  
Priyanka Ray ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Materials ◽  
Therapeutic Index ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Drug Molecules ◽  
Drug Conjugates ◽  
Life Threatening ◽  
The Stability

Research in the field of polymers and polymeric materials has garnered immense attention in the past few decades due to the versatile functional and structural capabilities of polymers which often can be manipulated for applications in the field of therapy and diagnosis for a host of diseases and disorders. Polymer therapeutics comprises polymer-drug and polymer-protein conjugates as well as supramolecular systems used as drug delivery systems. Although the pharmacological industry invests immensely in the design and discovery of novel drug molecules, small molecular drugs are often inefficient in targeting many diseases like deep seated low vasculature tumours, metastasized cancers and various autoimmune diseases. Coupled with a rapid clearance rate, low solubility, drug resistance and high off target toxicity these small molecular drugs often present modest benefits for a host of common diseases. In order to improve the therapeutic index of pre-existing drugs and shortening the translation from preclinical validation to clinical approval, a vast area of drug delivery research focuses on the improvement of drug carriers by various alterations. The major challenges currently faced by drug delivery systems include a low payload, transition through the desmoplastic barrier for solid tumours and high hepatic and renal clearance. In order to address these issues numerous polymer–protein and polymer-drug conjugates have been engineered and have reported to enhance the stability and pharmacokinetic properties of the active drugs. Highly toxic anticancer drugs like doxorubicin, cis-platin and gemcitabine have successfully been coupled with high molecular weight polymers to formulate targeted drug delivery agents, some of which have undergone successful clinical trials. Apart from PEGylated polymers, dendritic polymers and polyplexes with DNA or RNA moieties have also been considered as candidates for improving the therapeutic index of various drugs. Ongoing efforts in the development of polymer-based therapeutics are promising and open new horizons for personalized medicine for effective cure of various life-threatening diseases.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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