scholarly journals Gradient scaffolds for osteochondral tissue engineering and regeneration

2020 ◽  
Vol 8 (36) ◽  
pp. 8149-8170 ◽  
Author(s):  
Bin Zhang ◽  
Jie Huang ◽  
Roger J. Narayan
Keyword(s):  
Tissue Engineering ◽  
Subchondral Bone ◽  
Biological Tissue ◽  
Cartilage Surface ◽  
Tissue Scaffold ◽  
Engineering Approach ◽  
Physiological Properties ◽  
Tissue Engineering Approach ◽  
Osteochondral Tissue Engineering ◽  
Gradient Scaffolds

The tissue engineering approach for repairing osteochondral (OC) defects involves the fabrication of a biological tissue scaffold that mimics the physiological properties of natural OC tissue (e.g., the gradient transition between the cartilage surface and the subchondral bone).

scholarly journals The Arteriovenous Loop: Engineering of Axially Vascularized Tissue

2018 ◽  
Vol 59 (3-4) ◽  
pp. 286-299 ◽  
Author(s):  
Annika Weigand ◽  
Raymund E. Horch ◽  
Anja M. Boos ◽  
Justus P. Beier ◽  
Andreas Arkudas
Keyword(s):  
Tissue Engineering ◽  
Large Scale ◽  
Treatment Options ◽  
Current Treatment ◽  
Loop Model ◽  
Engineering Approach ◽  
In Vivo Tissue Engineering ◽  
Tissue Engineering Approach ◽  
Tissue Defects

Background: Most of the current treatment options for large-scale tissue defects represent a serious burden for the patients, are often not satisfying, and can be associated with significant side effects. Although major achievements have already been made in the field of tissue engineering, the clinical translation in case of extensive tissue defects is only in its early stages. The main challenge and reason for the failure of most tissue engineering approaches is the missing vascularization within large-scale transplants. Summary: The arteriovenous (AV) loop model is an in vivo tissue engineering strategy for generating axially vascularized tissues using the own body as a bioreactor. A superficial artery and vein are anastomosed to create an AV loop. This AV loop is placed into an implantation chamber for prevascularization of the chamber inside, e.g., a scaffold, cells, and growth factors. Subsequently, the generated tissue can be transplanted with its vascular axis into the defect site and anastomosed to the local vasculature. Since the blood supply of the growing tissue is based on the AV loop, it will be immediately perfused with blood in the recipient site leading to optimal healing conditions even in the case of poorly vascularized defects. Using this tissue engineering approach, a multitude of different axially vascularized tissues could be generated, such as bone, skeletal or heart muscle, or lymphatic tissues. Upscaling from the small animal AV loop model into a preclinical large animal model could pave the way for the first successful attempt in clinical application. Key Messages: The AV loop model is a powerful tool for the generation of different axially vascularized replacement tissues. Due to minimal donor site morbidity and the possibility to generate patient-specific tissues variable in type and size, this in vivo tissue engineering approach can be considered as a promising alternative therapy to current treatment options of large-scale defects.

Stem cell-derived cardiac patches: A tissue engineering approach to cardiac healing

2008 ◽  
Vol 44 (4) ◽  
pp. 806 ◽  
Author(s):  
G. Forte ◽  
Carotenuto F. ◽  
Pagliari F. ◽  
Pagliari S. ◽  
P. Cossa ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Engineering Approach ◽  
Tissue Engineering Approach

Tissue Engineering Approach to Implant Site Development

2017 ◽  
pp. 247-258
Author(s):  
Dan Clark ◽  
Igor Roitman ◽  
Mark C. Fagan ◽  
Richard T. Kao
Keyword(s):  
Tissue Engineering ◽  
Engineering Approach ◽  
Site Development ◽  
Tissue Engineering Approach

scholarly journals A tissue engineering approach to meniscus regeneration in a sheep model

2006 ◽  
Vol 14 (10) ◽  
pp. 1056-1065 ◽  
Author(s):  
C. Chiari ◽  
U. Koller ◽  
R. Dorotka ◽  
C. Eder ◽  
R. Plasenzotti ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sheep Model ◽  
Engineering Approach ◽  
Tissue Engineering Approach ◽  
Meniscus Regeneration

Engineered tissue micro-rings fabricated from aggregated fibroblasts and microfibres for a bottom-up tissue engineering approach

2019 ◽  
Vol 11 (3) ◽  
pp. 035029 ◽  
Author(s):  
Tao Sun ◽  
Qing Shi ◽  
Yibing Yao ◽  
Junzhong Sun ◽  
Huaping Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bottom Up ◽  
Engineering Approach ◽  
Tissue Engineering Approach ◽  
Engineered Tissue

scholarly journals A Tissue Engineering Approach for Periodontal Regeneration Based on a Biodegradable Double-Layer Scaffold and Adipose-Derived Stem Cells

2014 ◽  
Vol 20 (17-18) ◽  
pp. 2483-2492 ◽  
Author(s):  
João F. Requicha ◽  
Carlos A. Viegas ◽  
Fernando Muñoz ◽  
Jorge M. Azevedo ◽  
Isabel B. Leonor ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Double Layer ◽  
Periodontal Regeneration ◽  
Adipose Derived Stem Cells ◽  
Engineering Approach ◽  
Tissue Engineering Approach
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