Self-assembly of paramagnetic amphiphilic copolymers for synergistic therapy

2020 ◽  
Vol 8 (31) ◽  
pp. 6866-6876 ◽  
Author(s):  
Zhiliang Gao ◽  
Weiwei Mu ◽  
Yuan Tian ◽  
Yimao Su ◽  
Huanli Sun ◽  
...  
Keyword(s):  
Self Assembly ◽  
Amphiphilic Copolymers ◽  
Dual Mode ◽  
Theranostic Nanoparticles

Theranostic nanoparticles composed of amphiphilic paramagnetic polymers are assembled for dual mode imaging and synergistic therapy.

Bottom-up Evolution from Disks to High-Genus Polymersomes

2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Chain Entanglement ◽  
Bottom Up ◽  
New Approach ◽  
High Genus ◽  
Transmission Electron ◽  
Minimal Radius ◽  
Stop Flow

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>

Bottom-up Evolution from Disks to High-Genus Polymersomes

2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Chain Entanglement ◽  
Bottom Up ◽  
New Approach ◽  
High Genus ◽  
Transmission Electron ◽  
Minimal Radius ◽  
Stop Flow

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>

scholarly journals Synthesis of amphiphilic copolymers based on acrylic acid, fluoroalkyl acrylates and n-butyl acrylate in organic, aqueous–organic, and aqueous media via RAFT polymerization

RSC Advances ◽  
2017 ◽  
Vol 7 (39) ◽  
pp. 24522-24536 ◽  
Author(s):  
N. S. Serkhacheva ◽  
O. I. Smirnov ◽  
A. V. Tolkachev ◽  
N. I. Prokopov ◽  
A. V. Plutalova ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Polyacrylic Acid ◽  
Self Assembly ◽  
Butyl Acrylate ◽  
Raft Polymerization ◽  
Aqueous Media ◽  
Amphiphilic Copolymers

Hydrophilic and amphiphilic polymeric trithiocarbonates based on polyacrylic acid are able to provide polymerization-induced self-assembly in copolymerization of butyl and fluoroalkyl acrylates.

Dual-mode fluorescence switching induced by self-assembly of well-defined poly(arylene ether sulfone)s containing pyrene and amide moieties

2012 ◽  
Vol 48 (85) ◽  
pp. 10556 ◽  
Author(s):  
Jeyoung Park ◽  
Jisung Kim ◽  
Myungeun Seo ◽  
Jinhee Lee ◽  
Sang Youl Kim
Keyword(s):  
Self Assembly ◽  
Dual Mode ◽  
Arylene Ether ◽  
Fluorescence Switching

Self-assembly of fluorous amphiphilic copolymers with ionogels and surface switchable wettability

2018 ◽  
Vol 9 (17) ◽  
pp. 2258-2270 ◽  
Author(s):  
Santosh N. Chavan ◽  
Anil K. Padhan ◽  
Debaprasad Mandal
Keyword(s):  
Self Assembly ◽  
Amphiphilic Copolymers ◽  
Self Assembled

Fluorous amphiphilic ionic copolymers of 1H,1H,2H-Perfluoro-1-octene and vinyl imidazole self-assembled in different solvents to form ionogels and exhibits tunable substrate switching wettability.

scholarly journals Synthesis and self-assembly of AB2-type amphiphilic copolymers from biobased hydroxypropyl methyl cellulose and poly(L-lactide)

2019 ◽  
Vol 211 ◽  
pp. 133-140 ◽  
Author(s):  
Aijing Lu ◽  
Jielin Wang ◽  
Marleny Caceres Najarro ◽  
Suming Li ◽  
Andre Deratani
Keyword(s):  
Self Assembly ◽  
Methyl Cellulose ◽  
Amphiphilic Copolymers ◽  
Hydroxypropyl Methyl Cellulose

scholarly journals Self-assembly of amphiphilic copolymers containing polysaccharide: PISA versus nanoprecipitation, and the temperature effect

2020 ◽  
Vol 11 (29) ◽  
pp. 4729-4740 ◽  
Author(s):  
Djallal Ikkene ◽  
Ana Andreea Arteni ◽  
Malika Ouldali ◽  
Jean-Luc Six ◽  
Khalid Ferji
Keyword(s):  
Temperature Effect ◽  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Considerable Impact

The self-assembly methods and the temperature have a considerable impact on the morphology of the resulting nanoobjects in the case of amphiphilic glycopolymers.

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