Theranostics system caged in human serum albumin as a therapy for breast tumors

2020 ◽  
Vol 8 (31) ◽  
pp. 6877-6885
Author(s):  
Qingbing Wang ◽  
Xiaoxia Guo ◽  
Yi Chen ◽  
Zhiyuan Wu ◽  
Yu Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Breast Tumors ◽  
Biomimetic Materials ◽  
Good Biocompatibility

Biomimetic materials are attracting increasing attention in the field of drug delivery due to their low immunogenicity, good biocompatibility and degradability.

Non-toxic sonochemical synthesis of surface functionalized human serum albumin nanocapsules for targeted drug delivery

2012 ◽  
Vol 29 ◽  
pp. S228
Author(s):  
A. Rollett ◽  
T. Reiter ◽  
P. Nogueira ◽  
M. Cardinale ◽  
A. Loureiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Targeted Drug Delivery ◽  
Sonochemical Synthesis ◽  
Targeted Drug

Dual-Crosslinked Human Serum Albumin-Polymer Hydrogels for Affinity-Based Drug Delivery

2017 ◽  
Vol 302 (10) ◽  
pp. 1700243 ◽  
Author(s):  
Willem E. M. Noteborn ◽  
Yue Gao ◽  
Wim Jesse ◽  
Alexander Kros ◽  
Roxanne E. Kieltyka
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Polymer Hydrogels

Characterization and side effect analysis of a newly designed nanoemulsion targeting human serum albumin for drug delivery

2012 ◽  
Vol 98 ◽  
pp. 80-84 ◽  
Author(s):  
Adeleh Divsalar ◽  
Ali Akbar Saboury ◽  
Mohammad Nabiuni ◽  
Zohre Zare ◽  
Mohammad Esmaeil Kefayati ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Side Effect ◽  
Effect Analysis

Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Tania Caputo ◽  
Angela Maria Cusano ◽  
Menotti Ruvo ◽  
Anna Aliberti ◽  
Andrea Cusano
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Encapsulation Efficiency ◽  
Kinase Inhibitor ◽  
Force Microscopy ◽  
Atomic Force

Background: Drug delivery systems based on Human Serum Albumin (HSA) have been widely investigated due to their capability to interact with several molecules together with their nontoxicity, non-immunogenicity and biocompatibility. Sorafenib (SOR) is a kinase inhibitor used as the first-line treatment in hepatic cancer. However, because of its several intrinsic drawbacks (low solubility and bioavailability), there is a growing need for discovering new carriers able to overcome the current limitations. Objective: To study HSA particles loaded with SOR as a thermal responsive drug delivery system. Method: A detailed spectroscopy analysis of the HSA and SOR interaction in solution was carried out in order to characterize the temperature dependence of the complex. Based on this study, the synthesis of HSA particles loaded with SOR was optimized. Particles were characterized by Dynamic Light Scattering, Atomic Force Microscopy and by spectrofluorometer. Encapsulation efficiency and in vitro drug release were quantified by RP-HPLC. Results: HSA particles were monodispersed in size (≈ 200 nm); encapsulation efficiency ranged from 25% to 58%. Drug release studies that were performed at 37 °C and 50 °C showed that HS5 particles achieved a drug release of 0.430 µM in 72 hours at 50 °C in PBS buffer, accomplishing a 4.6-fold overall SOR release enhancement following a temperature increase from 37 °C to 50 °C. Conclusion: The system herein presented has the potential to exert a therapeutic action (in the nM range) triggering a sustained temperature-controllable release of relevant drugs.

Interaction Between Ketoconazole and Human Serum Albumin on Epoxy Modified Magnetic Nanoparticles for Drug Delivery

2013 ◽  
Vol 13 (10) ◽  
pp. 6522-6528 ◽  
Author(s):  
Esra Maltas ◽  
Mustafa Ozmen ◽  
Burak Yildirimer ◽  
Semahat Kucukkolbasi ◽  
Salih Yildiz
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Modified Magnetic Nanoparticles
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