Natural polymer-based bioabsorbable conducting wires for implantable bioelectronic devices

2020 ◽  
Vol 8 (47) ◽  
pp. 25323-25335
Author(s):  
Qianqian Niu ◽  
Xiangyu Huang ◽  
Shasha Lv ◽  
Xiang Yao ◽  
Suna Fan ◽  
...  
Keyword(s):  
Implantable Devices ◽  
Natural Polymer ◽  
Low Weight ◽  
Conducting Wire

A bioabsorbable conducting wire with excellent conductivity, bioabsorbability, biocompatibility, and low weight provides the possibility to construct fully bioabsorbable implantable devices.

Freeze fracture imaging and computer simulation of liposome structure: Membrane geometry and defects

1983 ◽  
Vol 41 ◽  
pp. 646-647
Author(s):  
Joseph A. Zasadzinski
Keyword(s):  
Liquid Crystalline ◽  
Freeze Fracture ◽  
Continuum Theory ◽  
Closed Surfaces ◽  
Straight Line ◽  
Low Weight ◽  
Concentric Spheres ◽  
Membrane Geometry ◽  
Dupin Cyclides ◽  
Limiting Case

At low weight fractions, many surfactant and biological amphiphiles form dispersions of lamellar liquid crystalline liposomes in water. Amphiphile molecules tend to align themselves in parallel bilayers which are free to bend. Bilayers must form closed surfaces to separate hydrophobic and hydrophilic domains completely. Continuum theory of liquid crystals requires that the constant spacing of bilayer surfaces be maintained except at singularities of no more than line extent. Maxwell demonstrated that only two types of closed surfaces can satisfy this constraint: concentric spheres and Dupin cyclides. Dupin cyclides (Figure 1) are parallel closed surfaces which have a conjugate ellipse (r1) and hyperbola (r2) as singularities in the bilayer spacing. Any straight line drawn from a point on the ellipse to a point on the hyperbola is normal to every surface it intersects (broken lines in Figure 1). A simple example, and limiting case, is a family of concentric tori (Figure 1b).To distinguish between the allowable arrangements, freeze fracture TEM micrographs of representative biological (L-α phosphotidylcholine: L-α PC) and surfactant (sodium heptylnonyl benzenesulfonate: SHBS)liposomes are compared to mathematically derived sections of Dupin cyclides and concentric spheres.

A Novel Approach: Trans-ascending Aorta Balloon Aortic Valvuloplasty via Sternotomy for Treating Severe Valvular Aortic Stenosis in a Low-Weight Infant

2014 ◽  
Vol 17 (1) ◽  
pp. 25 ◽  
Author(s):  
Lei Gao ◽  
Qin Wu ◽  
Xinhua Xu ◽  
Tianli Zhao ◽  
Wancun Jin ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Transesophageal Echocardiography ◽  
Severe Aortic Stenosis ◽  
Ascending Aorta ◽  
Balloon Aortic Valvuloplasty ◽  
Congenital Aortic Stenosis ◽  
Novel Approach ◽  
Low Weight ◽  
Aortic Valvuloplasty ◽  
Peak Gradient

<p><b>Background:</b> Severe congenital aortic stenosis in infants is a life-threatening congenital heart anomaly that is typically treated using percutaneous balloon aortic valvuloplasty.</p><p><b>Methods:</b> The usual route is the femoral artery under radiographic guidance. However, this procedure may be limited by the small size of the femoral artery in low-weight infants. An infant weighing only 7 kg with severe aortic stenosis (peak gradient was 103 mmHg) was successfully treated with a novel approach, that is trans-ascending aorta balloon aortic valvuloplasty guided by transesophageal echocardiography.</p><p><b>Results:</b> The patient tolerated the procedure well, and no major complications developed. After the intervention, transesophageal echocardiography indicated a significant reduction of the aortic valvular peak gradient from 103 mmHg to 22 mmHg, no aortic regurgitation was found. Eighteen months after the intervention, echocardiography revealed that the aortic valvular peak gradient had increased to 38 mmHg and that still no aortic regurgitation had occurred.</p><p><b>Conclusions:</b> In our limited experience, trans-ascending aorta balloon aortic valvuloplasty for severe aortic stenosis under transesophageal echocardiography guidance effectively reduces the aortic peak gradient. As this is a new procedure, long-term follow up and management will need to be established. It may be an alternative technique to treat congenital aortic stenosis in low-weight patients.</p>

Automatic Remote Monitoring of Implantable Cardiac Devices in Clinical Practice – The Lumos-T Safely Reduces Routine Office Device Follow-up (TRUST) Trial

2010 ◽  
Vol 6 (3) ◽  
pp. 87
Author(s):  
Niraj Varma ◽  
Keyword(s):  
Clinical Practice ◽  
Remote Monitoring ◽  
Home Monitoring ◽  
Implantable Devices ◽  
Cardiac Device ◽  
Cardiac Devices ◽  
Enhance Patient Safety ◽  
Implantable Cardiac Devices ◽  
Post Implantation

The use of implantable electronic cardiac devices is increasing. Post-implantation follow-up is important for monitoring both device function and patient condition; however, clinical practice is inconsistent. For example, implantable cardioverter–defibrillator follow-up schedules vary from every three months to yearly according to facility and physician preference and the availability of resources. Importantly, no surveillance occurs between follow-up visits. By contrast, implantable devices with automatic remote monitoring capability provide a means for performing constant surveillance, with the ability to identify salient problems rapidly. The Lumos-T Reduces Routine Office Device Follow-up Study (TRUST) demonstrated that remote home monitoring reduced clinic burden and allowed early detection of patient and/or system problems, enabling efficient monitoring and an opportunity to enhance patient safety. The results of the trial have significant implications for the management of patients receiving all forms of implantable electronic cardiac device.

Remote monitoring of implantable devices

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Giovanni B. Perego ◽  
Francesco M. Brasca
Keyword(s):  
Remote Monitoring ◽  
Implantable Devices

In-vivo evaluation of cisplatin nanoparticles encompass natural polymer

2020 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Bhavani J ◽  
Sunil Kumar Prajapati ◽  
Ravichandran S
Keyword(s):  
Tumor Volume ◽  
Nitrogen Mustard ◽  
Common Type ◽  
The Body ◽  
Nano Particles ◽  
Natural Polymer ◽  
Drinking Alcohol ◽  
In Vivo Evaluation

Cancer is assemblage diseases involving abnormal cell growth amid the potential of spread to other parts of the body due to tobacco use are the cause of about of cancer deaths. Another 10% is due to obesity, poor diet & drinking alcohol. In 2012 about 14.1 million new cases of cancer occurred globally. In females, the most common type is breast cancer. Cisplatin also known as cytophosphane is a nitrogen mustard alkylating agent from the oxazophosphinans groups were used to treat cancers & autoimmune disorders. Based on the above reasons I will fix the aim Preparation characterization of Cisplatin- nano particles  &  its anticancer activity. Solid tumor volume examination report showed that the assessment of different day indication 15,20,25 & 30th variations of different groups of tumor volumes were decreased CPG Nanoparticles (100 mg/kg)+ DAL(15th day 4.97±0.24↓), (20th day 0.6±0.13↓), (25th day 1.35±0.30↓) & (30th day 1.89±0.13↓).

Plantago Ovata and Locust Bean Gum as a Natural Polymer in Hydrodynamically Balanced Systems: A Review

2020 ◽  
Author(s):  
Ghildiyal s
Keyword(s):  
Drug Delivery ◽  
Locust Bean Gum ◽  
Main Role ◽  
Natural Polymer ◽  
Release Formulation ◽  
Sustained Drug Delivery ◽  
Modern Drug ◽  
Buccal Drug Delivery ◽  
Locust Bean ◽  
Ceratonia Siliqua L

Hydrodynamically Balanced systems have wide development as they have achieved the parameters of modern drug delivery system, it is a type of system which owes very tremendous and curative benefits for the delivery of oral controlled release dosage forms and have wide properties in many aspects such as its main role is to maintain the effective concentration in the system for longer period of time. To reduce the gastric mucosal irritation due to the presence of synthetic polymers, being a natural polymer incorporation of Plantago ovate (Psyllium Husk) could ease out the mucosal irritation in the gastric region. Due to its properties such as a rate-controlling polymer possessing a very good quality of swelling and good gelling nature, and also incorporated as a matrix-forming agent basically in the modified release formulation. Locust bean gum can be used as sustained-release carriers and release modifiers for the delivery of drugs. It is a neutral plant galactomannan extracted from the seeds (kernels) of the carob tree Ceratonia siliqua L fabaceae. Nowadays it is focussing polymer and a lot of researchers are focussing on exploring the potential in topical drug delivery, colonic drug delivery, oral sustained drug delivery, ocular drug delivery, buccal drug delivery.

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