Nonlinear, dissipative phenomena in whole blood clot mechanics

Soft Matter ◽  
2020 ◽  
Vol 16 (43) ◽  
pp. 9908-9916
Author(s):  
Gabriella P. Sugerman ◽  
Sapun H. Parekh ◽  
Manuel K. Rausch
Keyword(s):  
Whole Blood ◽  
Blood Clot ◽  
Uniaxial Testing

We use uniaxial testing to quantify nonlinear, dissipative mechanisms in whole blood clot mechanics.

Preparation and Mounting of Whole Blood Clot Samples for Mechanical Testing

2021 ◽  
Vol 1 (7) ◽  
Author(s):  
Gabriella P. Sugerman ◽  
Armaan Chokshi ◽  
Manuel K. Rausch
Keyword(s):  
Mechanical Testing ◽  
Whole Blood ◽  
Blood Clot

The Haemocompatibility of Biomaterials In Vitro: Investigations on the Mechanism of the Whole-blood Clot Formation Test

1992 ◽  
Vol 20 (3) ◽  
pp. 390-395 ◽  
Author(s):  
Thomas Groth ◽  
Katrin Derdau ◽  
Frank Strietzel ◽  
Frank Foerster ◽  
Hartmut Wolf
Keyword(s):  
Whole Blood ◽  
Blood Clotting ◽  
Blood Clot ◽  
Formation Rate ◽  
Clot Formation ◽  
Coagulation Cascade ◽  
Contact Activation ◽  
Human Fibrinogen ◽  
Static Conditions

Twenty years ago Imai & Nose introduced a whole-blood clotting test for the estimation of haemocompatibility of biomaterials in vitro In our paper a modification of this assay is described and the mechanism of clot formation further elucidated. It was found that neither the inhibition of platelet function nor the removal of platelets from blood significantly changed the clot formation rate on glass and polyvinyl chloride in comparison to the rate tor whole blood. Scanning electron microscopy demonstrated that platelets were not involved in clot formation near the blood/biomaterial interface. Thus, it was concluded that the system of contact activation of the coagulation cascade dominates during clot formation under static conditions. The latter conclusion was supported by the fact that preadsorption of human serum albumin or human fibrinogen onto the glass plates used, decreased the clot formation rate in the same manner.

scholarly journals PHYSIOLOGIC IMPACT OF CHRONIC KIDNEY DISEASE ON WHOLE BLOOD CLOT KINETICS AND STRENGTH

2012 ◽  
Vol 59 (13) ◽  
pp. E2096 ◽  
Author(s):  
Usman Baber ◽  
M. Urooj Zafar ◽  
jaime uribarri ◽  
Barbara Murphy ◽  
Avi Khan ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Whole Blood ◽  
Blood Clot

scholarly journals On the question of the treatment of uterine blood tumors

2020 ◽  
Vol 11 (4) ◽  
pp. 403-417
Author(s):  
Gr. N. Egorov
Keyword(s):  
Blood Vessel ◽  
Whole Blood ◽  
Total Mass ◽  
Lymphatic System ◽  
Blood Clot ◽  
Abdominal Cavity ◽  
The Body ◽  
Long Time ◽  
Life Threatening

The abdominal cavity is, in essence, an appendage of the lymphatic system, therefore, it cannot represent a completely foreign container for the blood poured out here. Indeed, the observations of Virchow, Wintrich and others show that whole blood can remain in this cavity for a long time (several days) without undergoing clotting (Pashutin). In view of this fact, it is natural to expect, as is confirmed by experiments, that most of the blood that has entered the abdominal cavity has time to be absorbed before it begins to coagulate. If a part of it, which failed to be absorbed in time, undergoes clotting, then this does not represent any particular disturbances in the overall economy of blood, the blood clot is completely absorbed after preliminary disintegration (fat). In this sense, hemorrhage into the abdominal cavity is not life-threatening, since the blood does not disappear for the body, but soon again, almost entirely, enters the total mass of the blood vessel.

Effect of Progesterone and Synthetic Progestins on Whole Blood Clot Formation and Erythrocyte Structure

2017 ◽  
Vol 23 (3) ◽  
pp. 607-617 ◽  
Author(s):  
Albe C. Swanepoel ◽  
Odette Emmerson ◽  
Etheresia Pretorius
Keyword(s):  
Whole Blood ◽  
Blood Clot ◽  
Thrombotic Event ◽  
Clot Formation ◽  
Erythrocyte Aggregation ◽  
Erythrocyte Morphology ◽  
Increased Risk ◽  
Blood Clots ◽  
Membrane Ultrastructure

AbstractCombined oral contraceptive (COC) use is a risk factor for venous thrombosis (VT) and related to the specific type of progestin used. VT is accompanied by inflammation and pathophysiological clot formation, that includes aberrant erythrocytes and fibrin(ogen) interactions. In this paper, we aim to determine the influence of progesterone and different synthetic progestins found in COCs on the viscoelasticity of whole blood clots, as well as erythrocyte morphology and membrane ultrastructure, in an in vitro laboratory study. Thromboelastography (TEG), light microscopy, and scanning electron microscopy were our chosen methods. Our results point out that progestins influence the rate of whole blood clot formation. Alterations to erythrocyte morphology and membrane ultrastructure suggest the presence of eryptosis. We also note increased rouleaux formation, erythrocyte aggregation, and spontaneous fibrin formation in whole blood which may explain the increased risk of VT associated with COC use. Although not all COC users will experience a thrombotic event, individuals with a thrombotic predisposition, due to inflammatory or hematological illness, should be closely monitored to prevent pathological thrombosis.

In vitro whole blood clot lysis by rt-PA is inversely correlated with baseline plasma levels of t-PA antigen

1994 ◽  
Vol 8 ◽  
pp. 43
Author(s):  
M. Colucci ◽  
S. Scopece ◽  
A. Gelato ◽  
L.G. Cavallo ◽  
N. Semeraro
Keyword(s):  
Whole Blood ◽  
Plasma Levels ◽  
Blood Clot ◽  
Clot Lysis

scholarly journals The factor XIII‐A Val34Leu polymorphism decreases whole blood clot mass at high fibrinogen concentrations

2020 ◽  
Vol 18 (4) ◽  
pp. 885-894
Author(s):  
Sravya Kattula ◽  
Zsuzsa Bagoly ◽  
Noémi Klára Tóth ◽  
László Muszbek ◽  
Alisa S. Wolberg
Keyword(s):  
Whole Blood ◽  
Factor Xiii ◽  
Blood Clot

A modified quantitative whole blood clot lysis method for general laboratory analysis of fibrinolysis

1990 ◽  
Vol 59 (1) ◽  
pp. 171-181 ◽  
Author(s):  
Mark B. Kahn ◽  
Sharon Palmer ◽  
Richard A. Marlar ◽  
Louis Fink
Keyword(s):  
Whole Blood ◽  
Blood Clot ◽  
Laboratory Analysis ◽  
Clot Lysis
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