scholarly journals 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases

2021 ◽  
Author(s):  
Maria-Agustina Rossi ◽  
Veronica Martinez ◽  
Philip Hinchliffe ◽  
Maria-Fernanda Mojica ◽  
Valerie Castillo ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Health Threat ◽  
Public Health Threat

Infections caused by multidrug resistant (MDR) bacteria are a major public health threat. Carbapenems are among the most potent antimicrobial agents that are commercially available to treat MDR bacteria. Bacterial...

scholarly journals A review on bacterial resistance to carbapenems: epidemiology, detection and treatment options

2020 ◽  
Vol 6 (3) ◽  
pp. FSO438 ◽  
Author(s):  
Ann A Elshamy ◽  
Khaled M Aboshanab
Keyword(s):  
Public Health ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Treatment Options ◽  
Carbapenem Resistance ◽  
Multidrug Resistant ◽  
Mechanisms Of Resistance ◽  
Carbapenem Resistant ◽  
Public Health Threat ◽  
Carbapenem Resistant Enterobacteriaceae

Carbapenems are a class of antimicrobial agents reserved for infections caused by multidrug-resistant microorganisms. The emergence of carbapenem resistance has become a serious public health threat. This type of antimicrobial resistance is spreading at an alarming rate, resulting in major outbreaks and treatment failure of community-acquired and nosocomial infections caused by the clinically relevant carbapenem-producing Enterobacteriaceae or carbapenem-resistant Enterobacteriaceae. This review is focused on carbapenem resistance, including mechanisms of resistance, history and epidemiology, phenotypic and genotypic detection in the clinically relevant bacterial pathogens and the possible treatment options available.

scholarly journals The Emergence of Extensively Drug-Resistant Tuberculosis (TB): TB/HIV Coinfection, Multidrug-Resistant TB and the Resulting Public Health Threat from Extensively Drug-Resistant TB, Globally and in Canada

2007 ◽  
Vol 18 (5) ◽  
pp. 289-291 ◽  
Author(s):  
Paul E Alexander ◽  
Prithwish De
Keyword(s):  
Public Health ◽  
Multidrug Resistant ◽  
Current Status ◽  
Drug Resistant ◽  
Global Public Health ◽  
Access To Treatment ◽  
Health Threat ◽  
Extensively Drug Resistant ◽  
Hiv Coinfection ◽  
Public Health Threat

Resistance to anti-tuberculosis (TB) drugs continues to present a major challenge to global public health. Resistance usually develops due to inadequate TB management, including improper use of medications, improper treatment regimens and failure to complete the treatment course. This may be due to an erratic supply or a lack of access to treatment, as well as to patient noncompliance. However, the emergence and transmission of drug-resistant TB, including the recently detected extensively drug resistant TB (XDR-TB), is driven, in part, by the synergistic relationship between TB and HIV (TB/HIV coinfection). There is evidence that persons infected with HIV are more likely to experience XDR-TB. XDR-TB is virtually untreatable with available TB medications. XDR-TB presents a grave global public health threat, particularly in high HIV prevalence settings. The present commentary discusses the current status of XDR-TB and draws attention to the urgency in addressing this problem, for both the global and Canadian public health networks. XDR-TB and the apparent XDR-TB and HIV association warrants further study.

scholarly journals Assessment of the In Vitro and In Vivo Antifungal Activity of NSC319726 against Candida auris

2021 ◽  
Author(s):  
Jizhou Li ◽  
Alix T. Coste ◽  
Daniel Bachmann ◽  
Dominique Sanglard ◽  
Frederic Lamoth
Keyword(s):  
Public Health ◽  
Antifungal Activity ◽  
Invasive Candidiasis ◽  
Multidrug Resistant ◽  
Candida Auris ◽  
Content Type ◽  
Health Threat ◽  
Public Health Threat

Candida auris is emerging as a major public health threat because of its ability to cause nosocomial outbreaks of severe invasive candidiasis. Management of C. auris infection is difficult because of its frequent multidrug-resistant profile for currently licensed antifungals.

scholarly journals Activity of Imipenem-Relebactam and Comparator Agents against Genetically Characterized Isolates of Carbapenem-Resistant Enterobacteriaceae

2019 ◽  
Vol 63 (9) ◽  
Author(s):  
Matthew C. Canver ◽  
Michael J. Satlin ◽  
Lars F. Westblade ◽  
Barry N. Kreiswirth ◽  
Liang Chen ◽  
...  
Keyword(s):  
Public Health ◽  
Klebsiella Pneumoniae ◽  
Antimicrobial Agents ◽  
Content Type ◽  
Health Threat ◽  
Carbapenem Resistant ◽  
Public Health Threat ◽  
Carbapenem Resistant Enterobacteriaceae

ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) strains are an urgent public health threat. We evaluated the in vitro activities of 19 antimicrobial agents, including imipenem-relebactam, against (i) 106 CRE bloodstream isolates that primarily expressed Klebsiella pneumoniae carbapenemase (KPC) and (ii) 20 OXA-48-like-expressing CRE isolates. Ninety-five percent of CRE bloodstream isolates were susceptible to imipenem-relebactam. In contrast to their comparable activities against KPC-producing CRE strains, ceftazidime-avibactam was more active in vitro against OXA-48-like CRE strains than was imipenem-relebactam (90% susceptible versus 15% susceptible).

scholarly journals Draft Genome Sequences of Four Metallo-Beta-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates, Including Two Colistin-Resistant Strains, from Cairo, Egypt

2019 ◽  
Vol 8 (7) ◽  
Author(s):  
Heba Attia ◽  
Richard Szubin ◽  
Aymen S. Yassin ◽  
Jonathan M. Monk ◽  
Ramy K. Aziz
Keyword(s):  
Public Health ◽  
Klebsiella Pneumoniae ◽  
Draft Genome ◽  
Multidrug Resistant ◽  
Beta Lactamase ◽  
Genome Sequences ◽  
Content Type ◽  
Health Threat ◽  
Public Health Threat ◽  
Resistant Strains

The emergence and spread of metallo-beta-lactamase-producing multidrug-resistant Klebsiella pneumoniae are a serious public health threat. Here, we report the draft genome sequences of four K. pneumoniae strains isolated from Cairo, Egypt, including two panresistant colistin-resistant strains.

The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship Programs

2019 ◽  
Vol 47 (4) ◽  
pp. 541-554 ◽  
Author(s):  
Thomas S. Murray ◽  
Jennifer Herbst
Keyword(s):  
Public Health ◽  
Antimicrobial Stewardship ◽  
Antibiotic Use ◽  
Multidrug Resistant ◽  
Fecal Microbiota ◽  
Clinical Indication ◽  
Fecal Microbiota Transplant ◽  
Health Threat ◽  
Multidrug Resistant Organisms ◽  
Public Health Threat

Multidrug resistant organisms (MDROs) are a public health threat that have reduced the effectiveness of many available antibiotics. Antimicrobial stewardship programs (ASPs) have been tasked with reducing antibiotic use and therefore the emergence of MDROs. While fecal microbiota transplant (FMT) has been proposed as therapy to reduce patient colonization of MDROs, this will require additional evidence to support an expansion of the current clinical indication for FMT. This article discusses the evidence and ethics of the expanded utilization of FMT by ASPs for reasons other than severe recurrent or refractory Clostridioides (formerly Clostridium) difficile infection.

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