scholarly journals A case of chain propagation: α-aminoalkyl radicals as initiators for aryl radical chemistry

2020 ◽  
Vol 11 (47) ◽  
pp. 12822-12828
Author(s):  
Timothée Constantin ◽  
Fabio Juliá ◽  
Nadeem S. Sheikh ◽  
Daniele Leonori
Keyword(s):  
Aryl Halides ◽  
Chain Propagation ◽  
Aryl Radical ◽  
Radical Chemistry

Aminoalkyl radicals can be used as both initiators and chain-carriers for the conversion of aryl halides into the corresponding radicals. This approach by-passes the requirement for strongly reducing photocatalysts.

Grignard reagent formation from aryl halides. There is no aryl radical intermediate along the dominant reaction channel

1999 ◽  
Vol 296 (1) ◽  
pp. 52-66 ◽  
Author(s):  
John F. Garst ◽  
J. Ronald Boone ◽  
Lisa Webb ◽  
Kathryn Easton Lawrence ◽  
James T. Baxter ◽  
...  
Keyword(s):  
Grignard Reagent ◽  
Aryl Halides ◽  
Reaction Channel ◽  
Aryl Radical ◽  
Radical Intermediate

Radical chemistry of the antitumor drug pazelliptine (PZE) in aqueous solution or intercalated in poly(dA)-poly(dT)

1996 ◽  
Vol 93 ◽  
pp. 194-202
Author(s):  
E Renault ◽  
MP Fontaine-Aupart ◽  
M Gardès-Albert ◽  
C Rivalle ◽  
E Bisagni
Keyword(s):  
Aqueous Solution ◽  
Antitumor Drug ◽  
Radical Chemistry

Sulfamides Direct Radical-Mediated Chlorination of Aliphatic C–H Bonds

2019 ◽  
Author(s):  
Melanie Short ◽  
Mina Shehata ◽  
Matthew Sanders ◽  
Jennifer Roizen
Keyword(s):  
Hydrogen Atom ◽  
Transfer Reaction ◽  
Hydrogen Atom Transfer ◽  
Chain Propagation ◽  
Propagation Mechanism ◽  
Atom Transfer ◽  
Radical Chain ◽  
Radical Intermediates ◽  
Transfer Processes ◽  
Unusual Position

Sulfamides guide intermolecular chlorine transfer to gamma-C(sp<sup>3</sup>) centers. This unusual position-selectivity arises because accessed sulfamidyl radical intermediates engage in otherwise rare 1,6-hydrogen-atom transfer processes. The disclosed chlorine-transfer reaction relies on a light-initiated radical chain-propagation mechanism to oxidize C(sp<sup>3</sup>)-H bonds.

Mild Temperature Copper-Catalyzed Amination of Aryl Halides with Aqueous Ammonia in the Presence of Pyridyldiketone Ligands

2019 ◽  
Author(s):  
Racha Abed Ali Abdine ◽  
Anna Walczak ◽  
Sultan Abu A Aeash ◽  
Gracjan Kurpik ◽  
Artur R. Stefankiewicz ◽  
...  
Keyword(s):  
Catalytic System ◽  
Aqueous Ammonia ◽  
Aryl Halides ◽  
Efficient Coupling ◽  
Ambidentate Ligand ◽  
Mild Temperature

Ambidentate ligand pyridyldiketones were used in combination with copper to catalyze maintain of aryl halides under very mild temperatures. This novel catalytic system allow efficient coupling in one of the smoothest conditions ever reported in literature.

Sulfamides Direct Radical-Mediated Chlorination of Aliphatic C–H Bonds

2019 ◽  
Author(s):  
Melanie Short ◽  
Mina Shehata ◽  
Matthew Sanders ◽  
Jennifer Roizen
Keyword(s):  
Hydrogen Atom ◽  
Transfer Reaction ◽  
Hydrogen Atom Transfer ◽  
Chain Propagation ◽  
Propagation Mechanism ◽  
Atom Transfer ◽  
Radical Chain ◽  
Radical Intermediates ◽  
Transfer Processes ◽  
Unusual Position

Sulfamides guide intermolecular chlorine transfer to gamma-C(sp<sup>3</sup>) centers. This unusual position-selectivity arises because accessed sulfamidyl radical intermediates engage in otherwise rare 1,6-hydrogen-atom transfer processes. The disclosed chlorine-transfer reaction relies on a light-initiated radical chain-propagation mechanism to oxidize C(sp<sup>3</sup>)-H bonds.

Sign in / Sign up

Export Citation Format

Share Document