scholarly journals LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis

2020 ◽  
Vol 11 (44) ◽  
pp. 11998-12008
Author(s):  
Alessandro Fracassi ◽  
Jianbo Cao ◽  
Naoko Yoshizawa-Sugata ◽  
Éva Tóth ◽  
Corey Archer ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fluorescent Dyes ◽  
Lipid Nanoparticles ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Mimetic Peptide

LDL-mimetic lipid nanoparticles, decorated with MRI contrast agents and fluorescent dyes, were prepared by the covalent attachments of an apoB100-mimetic peptide, Gd(iii)-chelate, and rhodamine to enhance atherosclerosis in the in vivo imaging.

scholarly journals Study on Establishing Reference Safe Concentrations of MRI Contrast Agents for Optimized Images: Paramagnetic Gd-DTPA-BMEA and Superparamagnetic Ferucarbotran

2021 ◽  
Vol 11 (3) ◽  
pp. 1165
Author(s):  
Wen-Tien Hsiao ◽  
Yi-Hong Chou ◽  
Jhong-Wei Tu ◽  
Ai-Yih Wang ◽  
Lu-Han Lai
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
In Vitro Experiments ◽  
Mri Contrast ◽  
In Vivo Experiments ◽  
Contrast Agent Injection

The purpose of this study is to establish the minimal injection doses of magnetic resonance imaging (MRI) contrast agents that can achieve optimized images while improving the safety of injectable MRI drugs. Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) and ferucarbotran, commonly used in clinical practice, were selected and evaluated with in vitro and in vivo experiments. MRI was acquired using T1-weighted (T1W) and T2-weighted (T2W) sequences, and the results were quantitatively analyzed. For in vitro experiments, results showed that T1W and T2W images were optimal when Gd-DTPA-bisamide (2-oxoethyl) (Gd-DTPA-BMEA) and ferucarbotran were diluted to a volume percentage of 0.6% and 0.05%; all comparisons were significant differences in grayscale statistics using one-way analysis of variance (ANOVA). For in vivo experiments, the contrast agent with optimal concentration percentages determined from in vitro experiments were injected into mice with an injection volume of 100 μL, and the images of brain, heart, liver, and mesentery before and after injection were compared. The statistical results showed that the p values of both T1W and T2W were less than 0.001, which were statistically significant. Under safety considerations for MRI contrast agent injection, optimized MRI images could still be obtained after reducing the injection concentration, which can provide a reference for the safety concentrations of MRI contrast agent injection in the future.

scholarly journals Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Christian E. Anderson ◽  
Mette Johansen ◽  
Bernadette O. Erokwu ◽  
He Hu ◽  
Yuning Gu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Ex Vivo ◽  
Single Agent ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Spatiotemporal Resolution ◽  
Mri Contrast ◽  
Contrast Magnetic Resonance

AbstractSynchronous assessment of multiple MRI contrast agents in a single scanning session would provide a new “multi-color” imaging capability similar to fluorescence imaging but with high spatiotemporal resolution and unlimited imaging depth. This multi-agent MRI technology would enable a whole new class of basic science and clinical MRI experiments that simultaneously explore multiple physiologic/molecular events in vivo. Unfortunately, conventional MRI acquisition techniques are only capable of detecting and quantifying one paramagnetic MRI contrast agent at a time. Herein, the Dual Contrast – Magnetic Resonance Fingerprinting (DC-MRF) methodology was extended for in vivo application and evaluated by simultaneously and dynamically mapping the intra-tumoral concentration of two MRI contrast agents (Gd-BOPTA and Dy-DOTA-azide) in a mouse glioma model. Co-registered gadolinium and dysprosium concentration maps were generated with sub-millimeter spatial resolution and acquired dynamically with just over 2-minute temporal resolution. Mean tumor Gd and Dy concentration measurements from both single agent and dual agent DC-MRF studies demonstrated significant correlations with ex vivo mass spectrometry elemental analyses. This initial in vivo study demonstrates the potential for DC-MRF to provide a useful dual-agent MRI platform.

scholarly journals Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode magnetic resonance imaging

2020 ◽  
Vol 11 ◽  
pp. 1000-1009
Author(s):  
Miao Qin ◽  
Yueyou Peng ◽  
Mengjie Xu ◽  
Hui Yan ◽  
Yizhu Cheng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Dual Mode ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

The multimodal magnetic resonance imaging (MRI) technique has been extensively studied over the past few years since it offers complementary information that can increase diagnostic accuracy. Simple methods to synthesize contrast agents are necessary for the development of multimodal MRI. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T 1–T 2 dual-mode MRI contrast agents were successfully designed and synthesized. In order to increase hydrophilicity and biocompatibility, the nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA). The results show that iron (Fe) and gadolinium (Gd) were homogeneously distributed throughout the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxation time analysis was performed on the images obtained from the 3.0 T scanner. The results demonstrated that r 1 and r 2 maximum values were 67.57 ± 6.2 and 24.2 ± 1.46 mM−1·s−1, respectively. In vivo T 1- and T 2-weighted images showed that FGDA nanocubes act as a dual-mode contrast agent enhancing MRI quality. Overall, these experimental results suggest that the FGDA nanocubes are interesting tools that can be used to increase MRI quality, enabling accurate clinical diagnostics.

The In Vivo Radiosensitizing Effect of Gold Nanoparticles Based MRI Contrast Agents

Small ◽  
2014 ◽  
Vol 10 (6) ◽  
pp. 1116-1124 ◽  
Author(s):  
Imen Miladi ◽  
Christophe Alric ◽  
Sandrine Dufort ◽  
Pierre Mowat ◽  
Aurélie Dutour ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Radiosensitizing Effect

Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications

2020 ◽  
Vol 20 (17) ◽  
pp. 1767-1780 ◽  
Author(s):  
Huan Yue ◽  
Ja Young Park ◽  
Yongmin Chang ◽  
Gang Ho Lee
Keyword(s):  
Contrast Agents ◽  
In Vivo Imaging ◽  
Biomedical Imaging ◽  
Mri Contrast Agents ◽  
Polyol Synthesis ◽  
Imaging Agents ◽  
Bibliographic Databases ◽  
Mri Contrast ◽  
X Ray

Imaging agents are crucial in diagnosing diseases. Ultrasmall lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Eu, Gd, and Dy) are promising materials as high-performance imaging agents because of their excellent magnetic, optical, and X-ray attenuation properties which can be applied as magnetic resonance imaging (MRI), fluorescence imaging (FI), and X-ray computed tomography (CT) agents, respectively. Ultrasmall Ln2O3 NPs (Ln = Eu, Gd, and Dy) are reviewed here. The reviewed topics include polyol synthesis, characterization, properties, and biomedical imaging applications of ultrasmall Ln2O3 NPs. Recently published papers were used as bibliographic databases. A polyol method is a simple and efficient one-pot synthesis for preparing ultrasmall Ln2O3 NPs. Ligand-coated ultrasmall Ln2O3 NPs have good colloidal stability, biocompatibility, and renal excretion ability suitable for in vivo imaging applications. Ultrasmall Eu2O3 NPs display photoluminescence in the red region suitable for use as FI agents. Ultrasmall Gd2O3 NPs have r1 values higher than those of commercial molecular contrast agents and r2/r1 ratios close to 1, which make them eligible for use as T1 MRI contrast agents. Ultrasmall Dy2O3 NPs exhibit high r2 and negligible r1 values, which make them suitable for use as T2 MRI contrast agents. All ultrasmall Ln2O3 NPs have high X-ray attenuation powers which make them suitable for use as CT contrast agents. Unmixed, mixed, or doped ultrasmall Ln2O3 NPs with different Ln are extremely useful for in vivo imaging applications in MRI, CT, FI, MRI-CT, MRI-FI, CT-FI, and MRI-CT-FI.

Investigation of cyano-bridged coordination nanoparticles Gd3+/[Fe(CN)6]3−/d-mannitol as T1-weighted MRI contrast agents

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 11899-11903 ◽  
Author(s):  
M. Perrier ◽  
A. Gallud ◽  
A. Ayadi ◽  
S. Kennouche ◽  
C. Porredon ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast

Ultra small Gd3+/[Fe(CN)6]3− nanoparticles are investigated in vivo as contrast agents for Magnetic Resonance Imaging.

Synthesis and Biological Evaluation of Rhein-Based MRI Contrast Agents for in Vivo Visualization of Necrosis

2018 ◽  
Vol 90 (22) ◽  
pp. 13249-13256 ◽  
Author(s):  
Li Bian ◽  
Meng Gao ◽  
Dongjian Zhang ◽  
Aiyan Ji ◽  
Chang Su ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Biological Evaluation ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Synthesis And Biological Evaluation

scholarly journals Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM

Sensors ◽  
2015 ◽  
Vol 15 (12) ◽  
pp. 31973-31986 ◽  
Author(s):  
Yuka Miyake ◽  
Syungo Ishikawa ◽  
Yu Kimura ◽  
Aoi Son ◽  
Hirohiko Imai ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

2013 ◽  
Author(s):  
Brigit den Adel ◽  
Mat J. Daemen ◽  
Robert E. Poelmann ◽  
Louise van der Weerd
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Atherosclerotic Plaques ◽  
Resonance Imaging ◽  
Plaque Vulnerability ◽  
Mri Contrast ◽  
Atherosclerosis Development ◽  
Targeted Mri ◽  
Molecular Resonance

Recent advances in molecular resonance imaging of atherosclerosis enable to visualize atherosclerotic plaques in vivo using molecular targeted contrast agents. This offers opportunities to study atherosclerosis development and plaque vulnerability noninvasively. In this review, we discuss MRI contrast agents targeted toward atherosclerotic plaques and illustrate how these new imaging platforms could assist in our understanding of atherogenesis and atheroprogression. In particular, we highlight the challenges and limitations of the different contrast agents and hurdles for clinical application. We describe the most promising existing compounds to detect atherosclerosis and plaque vulnerability. Of particular interest are the fibrin-targeted compounds that detect thrombi and, furthermore, the contrast agents targeted to integrins that allow to visualize plaque neovascularization. Moreover, vascular cell adhesion molecule 1–targeted iron oxides seem promising for early detection of atherosclerosis. These targeted MRI contrast agents, however promising and well characterized in (pre)clinical models, lack specificity for plaque vulnerability.

scholarly journals Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

2015 ◽  
Vol 51 (14) ◽  
pp. 2782-2785 ◽  
Author(s):  
Serhat Gündüz ◽  
Nobuhiro Nitta ◽  
Sandip Vibhute ◽  
Sayaka Shibata ◽  
Martin E. Mayer ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Diffusion Properties

A smart dendrimeric MRI agent sensitive to calcium has been prepared exhibiting advantageous diffusion properties in vivo.

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