scholarly journals Core remodeling leads to long wavelength fluoro-coumarins

2020 ◽  
Vol 11 (28) ◽  
pp. 7302-7307 ◽  
Author(s):  
Siddharth S. Matikonda ◽  
Joseph Ivanic ◽  
Miguel Gomez ◽  
Gabrielle Hammersley ◽  
Martin J. Schnermann
Keyword(s):  
Molecular Weight ◽  
Near Infrared ◽  
Low Molecular Weight ◽  
Long Wavelength

Fluoro-Coumarins are a novel class of far-red and near-infrared solvent sensitive dyes of exceptionally low molecular weight.

scholarly journals A targeted low molecular weight near-infrared fluorescent probe for prostate cancer

2010 ◽  
Vol 20 (23) ◽  
pp. 7124-7126 ◽  
Author(s):  
Tiancheng Liu ◽  
Lisa Y. Wu ◽  
Mark R. Hopkins ◽  
Joseph K. Choi ◽  
Clifford E. Berkman
Keyword(s):  
Prostate Cancer ◽  
Molecular Weight ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Low Molecular Weight

Low molecular weight polyethylenimine-conjugated gold nanospheres: a platform for selective gene therapy controlled by near-infrared light

Nanomedicine ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. 511-534 ◽  
Author(s):  
Fei Liu ◽  
Fen-fen Kong ◽  
Qing-po Li ◽  
Hong Yuan ◽  
Yong-zhong Du ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Weight ◽  
Near Infrared ◽  
Infrared Light ◽  
Low Molecular Weight ◽  
Gold Nanospheres ◽  
Near Infrared Light

scholarly journals Benzil Photoperoxidations in Polymer Films and Crosslinking by the Resultant Benzoyl Peroxides in Polystyrene and Other Polymers

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5154
Author(s):  
Ivan Lukáč ◽  
Branislav Husár ◽  
Martin Danko ◽  
Richard G. Weiss
Keyword(s):  
Molecular Weight ◽  
Polymer Films ◽  
Glassy Polymer ◽  
Polymer Networks ◽  
Polymer Chains ◽  
Solid Surfaces ◽  
Low Molecular Weight ◽  
Long Wavelength ◽  
Covalently Linked ◽  
Phenyl Vinyl

Benzil (BZ) can be converted almost quantitatively to benzoyl peroxide (BP) in aerated polymer films upon irradiation at >400 nm (i.e., the long-wavelength edge of the n→π* absorption band of BZ, where BP does not absorb). Here, we summarize results for the photoperoxidation of BZ structures with molecular oxygen, principally in glassy polymer matrices. Some of the polymers are doped directly with BZ or its derivatives, and others, contain covalently attached BZ pendant groups from which BP groups are derived. While the decomposition of low-molecular-weight BP doped into polymer films (such as those of polystyrene (PS)) results in a net decrease in polymer molecular weight, thermal decomposition of pendant BP groups is an efficient method for chain crosslinking. Crosslinking of PS films doped with a molecule containing two covalently linked BZ or BP groups proceeds in a similar fashion. Free radicals from the covalently attached BP allow grafting of new monomers, as well. Additionally, the use of radiation filtered through masks has been used to create patterns of polymers on solid surfaces. Crosslinking of photodegradable poly(phenyl vinyl ketone) with BP structures obtained by photoperoxidation of BZ structures for the preparation of photodegradable polymer networks is described as well. In sum, the use of BZ and BP and their derivatives offers simple and convenient routes for modifying polymer chains and, especially, for crosslinking them. Specific applications of each use and process are provided. Although applications with PS are featured here, the methodologies described are amenable to a wide variety of other polymers.

scholarly journals Receptor-Targeted Fluorescence-Guided Surgery With Low Molecular Weight Agents

2021 ◽  
Vol 11 ◽  
Author(s):  
Servando Hernandez Vargas ◽  
Christie Lin ◽  
Hop S. Tran Cao ◽  
Naruhiko Ikoma ◽  
Solmaz AghaAmiri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Near Infrared ◽  
Residual Disease ◽  
Imaging Modality ◽  
Intraoperative Imaging ◽  
Tumor Resection ◽  
Low Molecular Weight ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Tumor Selective

Cancer surgery remains the primary treatment option for most solid tumors and can be curative if all malignant cells are removed. Surgeons have historically relied on visual and tactile cues to maximize tumor resection, but clinical data suggest that relapse occurs partially due to incomplete cancer removal. As a result, the introduction of technologies that enhance the ability to visualize tumors in the operating room represents a pressing need. Such technologies have the potential to revolutionize the surgical standard-of-care by enabling real-time detection of surgical margins, subclinical residual disease, lymph node metastases and synchronous/metachronous tumors. Fluorescence-guided surgery (FGS) in the near-infrared (NIRF) spectrum has shown tremendous promise as an intraoperative imaging modality. An increasing number of clinical studies have demonstrated that tumor-selective FGS agents can improve the predictive value of fluorescence over non-targeted dyes. Whereas NIRF-labeled macromolecules (i.e., antibodies) spearheaded the widespread clinical translation of tumor-selective FGS drugs, peptides and small-molecules are emerging as valuable alternatives. Here, we first review the state-of-the-art of promising low molecular weight agents that are in clinical development for FGS; we then discuss the significance, application and constraints of emerging tumor-selective FGS technologies.

scholarly journals Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

2021 ◽  
Author(s):  
Fabio de Moliner ◽  
Ina Biazruchka ◽  
Karolina Konsewicz ◽  
Sam Benson ◽  
Suraj Singh ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Small Molecule ◽  
Near Infrared ◽  
Aqueous Media ◽  
Biological Imaging ◽  
Low Molecular Weight ◽  
Synthetic Approach ◽  
Spectral Window ◽  
Infrared Spectral ◽  
Environmentally Sensitive

AbstractThe development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.

A new BODIPY-based long-wavelength fluorescent probe for chromatographic analysis of low-molecular-weight thiols

2014 ◽  
Vol 406 (26) ◽  
pp. 6723-6733 ◽  
Author(s):  
Li-Yun Zhang ◽  
Feng-Qin Tu ◽  
Xiao-Feng Guo ◽  
Hong Wang ◽  
Peng Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Fluorescent Probe ◽  
Chromatographic Analysis ◽  
Low Molecular Weight ◽  
Long Wavelength
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