scholarly journals Catalytic enantioselective synthesis of carbocyclic and heterocyclic spiranes via a decarboxylative aldol cyclization

2020 ◽  
Vol 11 (28) ◽  
pp. 7390-7395 ◽  
Author(s):  
Kazato Inanaga ◽  
Marco Wollenburg ◽  
Shoshana Bachman ◽  
Nicholas J. Hafeman ◽  
Brian M. Stoltz
Keyword(s):  
Enantioselective Synthesis ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Aldol Cyclization

The synthesis of a variety of enantioenriched 1,3-diketospiranes from the corresponding racemic allyl β-ketoesters via an interrupted asymmetric allylic alkylation is disclosed.

Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

2019 ◽  
Vol 23 (11) ◽  
pp. 1168-1213 ◽  
Author(s):  
Samar Noreen ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Irum Shahzadi ◽  
Ali Irfan ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Allylic Alkylation ◽  
Research Groups ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Potential ◽  
Long Time ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions. Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

scholarly journals Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

2014 ◽  
Vol 54 (1) ◽  
pp. 179-183 ◽  
Author(s):  
Katerina M. Korch ◽  
Christian Eidamshaus ◽  
Douglas C. Behenna ◽  
Sangkil Nam ◽  
David Horne ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Asymmetric

scholarly journals Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

2014 ◽  
Vol 127 (1) ◽  
pp. 181-185 ◽  
Author(s):  
Katerina M. Korch ◽  
Christian Eidamshaus ◽  
Douglas C. Behenna ◽  
Sangkil Nam ◽  
David Horne ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Asymmetric

scholarly journals Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles via decarboxylative asymmetric allylic alkylation

2019 ◽  
Vol 10 (3) ◽  
pp. 788-792 ◽  
Author(s):  
Alexander W. Sun ◽  
Stephan N. Hess ◽  
Brian M. Stoltz
Keyword(s):  
Enantioselective Synthesis ◽  
Alkylation Reaction ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation

An enantioselective synthesis of diverse N4-Boc-protected α,α-disubstituted piperazin-2-ones and tetrahydropyrimidin-2-ones using the palladiumcatalyzed decarboxylative allylic alkylation reaction has been achieved.

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