scholarly journals Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

2020 ◽  
Vol 11 (30) ◽  
pp. 7858-7863 ◽  
Author(s):  
Ganesh K. Mothukuri ◽  
Sangram S. Kale ◽  
Carl L. Stenbratt ◽  
Alessandro Zorzi ◽  
Jonathan Vesin ◽  
...  
Keyword(s):  
Chemical Reactions ◽  
Combinatorial Libraries ◽  
Solution Phase ◽  
Thrombin Inhibitor ◽  
Phase Synthesis ◽  
Synthesis Strategy ◽  
Solution Phase Synthesis ◽  
Three Components

Combination of three efficient chemical reactions allows for solution-phase synthesis of 3780 macrocycles and identification of potent thrombin inhibitor.

ChemInform Abstract: Synthesis and Evaluation of Paclitaxel C7 Derivatives: Solution-Phase Synthesis of Combinatorial Libraries.

ChemInform ◽  
2010 ◽  
Vol 30 (11) ◽  
pp. no-no
Author(s):  
Laxminarayan Bhat ◽  
Yanbin Liu ◽  
Sam F. Victory ◽  
Richard H. Himes ◽  
Gunda I. Georg
Keyword(s):  
Combinatorial Libraries ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

1998 ◽  
Vol 8 (22) ◽  
pp. 3181-3186 ◽  
Author(s):  
Laxminarayan Bhat ◽  
Yanbin Liu ◽  
Sam F. Victory ◽  
Richard H. Himes ◽  
Gunda I. Georg
Keyword(s):  
Combinatorial Libraries ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

ChemInform Abstract: Solution-Phase Synthesis of Novel Linear Oxyamine Combinatorial Libraries with Antibacterial Activity.

ChemInform ◽  
2010 ◽  
Vol 29 (31) ◽  
pp. no-no
Author(s):  
P.-P. KUNG ◽  
R. BHARADWAJ ◽  
A. S. FRASER ◽  
D. R. COOK ◽  
A. M. KAWASAKI ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Combinatorial Libraries ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

scholarly journals The Synthesis of Two Combinatorial Libraries Using a 4-(2-Thienyl)-pyrrole Template

2002 ◽  
Vol 55 (12) ◽  
pp. 789 ◽  
Author(s):  
Rohan A. Davis ◽  
Anthony R. Carroll ◽  
Ronald J. Quinn
Keyword(s):  
Reductive Amination ◽  
Combinatorial Libraries ◽  
Solution Phase ◽  
Primary Amines ◽  
The Novel ◽  
Compound Library ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Tert Butyl ◽  
Solution Phase Synthesis

The synthesis of the novel biaryl compound, 4-(2-thienyl)-1H-pyrrole-2-carbaldehyde (1), by Suzuki–Miyaura coupling conditions is reported. Compound (1) was subsequently used as a combinatorial template in the parallel solution-phase synthesis of an amine and imine compound library. The amine library was produced using reductive amination conditions, and purification was achieved by a liquid–liquid partition followed by silica chromatography to afford ten amine analogues. The imine library consisted of five compounds, which were synthesized using volatile primary amines that allowed purification by evaporation. The synthesis of the novel and related biaryl carbaldehyde, tert-butyl-2-(5-formyl-1H-pyrrol-3-yl)-1H-pyrrole-1-carboxylate (2) is also reported.

Solution-Phase Synthesis of Novel Linear Oxyamine Combinatorial Libraries with Antibacterial Activity

1998 ◽  
Vol 63 (6) ◽  
pp. 1846-1852 ◽  
Author(s):  
Pei-Pei Kung ◽  
Ramesh Bharadwaj ◽  
Allister S. Fraser ◽  
Daniel R. Cook ◽  
Andrew M. Kawasaki ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Combinatorial Libraries ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis
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