scholarly journals Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens

2020 ◽  
Vol 11 (29) ◽  
pp. 7676-7684 ◽  
Author(s):  
Ruoyao Zhang ◽  
Guangle Niu ◽  
Qing Lu ◽  
Xiaolin Huang ◽  
Joe H. C. Chau ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Discrimination

We present a series of AIEgens for cancer cell discrimination and dynamic viability monitoring.

An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination

2018 ◽  
Vol 42 (24) ◽  
pp. 19818-19826 ◽  
Author(s):  
Jayanta Mandal ◽  
Pravat Ghorai ◽  
Paula Brandão ◽  
Kunal Pal ◽  
Parimal Karmakar ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Low Cost ◽  
Ph Sensor ◽  
Low Ph ◽  
Cell Permeability ◽  
Ph Range ◽  
Cell Discrimination

A simple, low cost aminoquinoline based pH sensor,HLwas prepared and it works at a low pH range.HLexhibits cell permeability and used as an effective tool for differentiating between normal and cancer cells.

SP94-Targeted Nanoparticles Enhance the Efficacy of Sorafenib and Improve Liver Cancer Cell Discrimination

2020 ◽  
Author(s):  
Meenu Chopra ◽  
Agustìn Sgro ◽  
Marck Norret ◽  
Pilar Blancafort ◽  
K. Swaminathan Iyer ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Targeted Nanoparticles ◽  
Cell Discrimination

scholarly journals Photodynamic Therapy with Tumor Cell Discrimination through RNA-Targeting Ability of Photosensitizer

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5990
Author(s):  
Yuan Xu ◽  
Yang Tan ◽  
Xiuqin Ma ◽  
Xiaoyi Jin ◽  
Ye Tian ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Electrostatic Interactions ◽  
Tumor Location ◽  
Normal Cells ◽  
Design And Synthesis ◽  
Rna Targeting ◽  
Targeting Ability ◽  
Cell Discrimination

Photodynamic therapy (PDT) represents an effective treatment to cure cancer. The targeting ability of the photosensitizer is of utmost importance. Photosensitizers that discriminate cancer cells can avoid the killing of normal cells and improve PDT efficacy. However, the design and synthesis of photosensitizers conjugated with a recognition unit of cancer cell markers is complex and may not effectively target cancer. Considering that the total RNA content in cancer cells is commonly higher than in normal cells, this study has developed the photosensitizer QICY with RNA-targeting abilities for the discrimination of cancer cells. QICY was specifically located in cancer cells rather than normal cells due to their stronger electrostatic interactions with RNA, thereby further improving the PDT effects on the cancer cells. After intravenous injection into mice bearing a xenograft tumor, QICY accumulated into the tumor location through the enhanced permeability and retention effect, automatically targeted cancer cells under the control of RNA, and inhibited tumor growth under 630 nm laser irradiation without obvious side effects. This intelligent photosensitizer with RNA-targeting ability not only simplifies the design and synthesis of cancer-cell-targeting photosensitizers but also paves the way for the further development of highly efficient PDTs.

Nanofabricated 3D cage-like structures for cancer cell discrimination

2015 ◽  
Author(s):  
Barbara Spagnolo ◽  
Leonardo Sileo ◽  
Enrico Domenico Lemma ◽  
Virgilio Brunetti ◽  
Elisa De Luca ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Discrimination

scholarly journals Cancer Cell Discrimination Using Host–Guest “Doubled” Arrays

2017 ◽  
Vol 139 (23) ◽  
pp. 8008-8012 ◽  
Author(s):  
Ngoc D. B. Le ◽  
Gulen Yesilbag Tonga ◽  
Rubul Mout ◽  
Sung-Tae Kim ◽  
Marcos E. Wille ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Discrimination
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