scholarly journals A happy medium: the synthesis of medicinally important medium-sized rings via ring expansion

2020 ◽  
Vol 11 (11) ◽  
pp. 2876-2881 ◽  
Author(s):  
Aimee K. Clarke ◽  
William P. Unsworth
Keyword(s):  
Medicinal Chemistry ◽  
Ring Expansion ◽  
Expansion Strategies

Ring expansion strategies are ideally suited to make synthetically challenging, medium-sized rings with much potential in medicinal chemistry.

Advances in Aza-Claisen-Rearrangement-Induced Ring-Expansion Strategies

2017 ◽  
Vol 6 (9) ◽  
pp. 1117-1129 ◽  
Author(s):  
Jong-Wha Jung ◽  
Seok-Ho Kim ◽  
Young-Ger Suh
Keyword(s):  
Claisen Rearrangement ◽  
Ring Expansion ◽  
Expansion Strategies

scholarly journals Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion

2017 ◽  
Vol 15 (14) ◽  
pp. 2906-2909 ◽  
Author(s):  
Alexander Sapegin ◽  
Angelina Osipyan ◽  
Mikhail Krasavin
Keyword(s):  
Medicinal Chemistry ◽  
Ring Expansion ◽  
Membered Ring ◽  
Synthetic Methods ◽  
Ring Systems ◽  
New Hire ◽  
Imidazoline Ring

A facile approach to hitherto unknown ten-membered ring systems via a hydrolytic imidazoline ring expansion (HIRE) is described. Medium-sized rings are scarce in the contemporary medicinal chemistry toolbox. The new HIRE strategy broadens the arsenal of synthetic methods to obtain such scaffolds.

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