scholarly journals Strategies for remote enantiocontrol in chiral gold(iii) complexes applied to catalytic enantioselective γ,δ-Diels–Alder reactions

2020 ◽  
Vol 11 (25) ◽  
pp. 6450-6456 ◽  
Author(s):  
Jolene P. Reid ◽  
Mingyou Hu ◽  
Susumu Ito ◽  
Banruo Huang ◽  
Cynthia M. Hong ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Diels Alder ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Square Planar ◽  
Non Covalent Interactions ◽  
Covalent Interactions

Chiral square planar gold(iii) complexes are employed as catalysts in asymmetric Diels–Alder reactions. The non-covalent interactions responsible for the enantioselectivity are revealed through multivariate linear regression analysis.

Correlation between FA and ADC, number and length of the periprostatic neurovascular fibers

2021 ◽  
pp. 039156032110637
Author(s):  
Valerio Di Paola ◽  
Angelo Totaro ◽  
Giacomo Avesani ◽  
Benedetta Gui ◽  
Andrea Boni ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Negative Correlation ◽  
Multivariate Regression ◽  
Linear Regression Analysis ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Independent Variables ◽  
Fiber Tracts ◽  
Good Agreement

Purpose: Our aim was to explore the relation between FA and ADC, number and length of the periprostatic neurovascular fibers (PNF) by means of 1.5 T Diffusion Tensor Imaging (DTI) imaging through a multivariate linear regression analysis model. Methods: For this retrospective study, 56 patients (mean age 63.5 years), who underwent 1.5-T prostate MRI, including DTI, were enrolled between October 2014 and December 2018. Multivariate regression analysis was performed to evaluate the statistically significant correlation between FA values (dependent variable) and ADC, the number and the length of PNF (independent variables), if p-value <0.05. A value of 0.5 indicated poor agreement; 0.5–0.75, moderate agreement; 0.75–0.9, good agreement; 0.61–0.80, good agreement; and 0.9–1.00, excellent agreement. Results: The overall fit of the multivariate regression model was excellent, with R2 value of 0.9445 ( R2 adjusted 0.9412; p < 0.0001). Multivariate linear regression analysis showed a statistically significant correlation ( p < 0.05) for all the three independent variables. The r partial value was −0.9612 for ADC values ( p < 0.0001), suggesting a strong negative correlation, 0.4317 for the number of fiber tracts ( p < 0.001), suggesting a moderate positive correlation, and −0.306 for the length of the fiber tracts ( p < 0.05), suggesting a weak negative correlation. Conclusions: Our multivariate linear regression model has demonstrated a statistically significant correlation between FA values of PNF with other DTI parameters, in particular with ADC.

scholarly journals Relationship between Thyroid and Kidney Function: Analysis from the Korea National Health and Nutrition Examination Survey Between 2013 and 2015

2020 ◽  
Vol 45 (3) ◽  
pp. 442-454 ◽  
Author(s):  
Sang Hyuk Kim ◽  
Hyang Ki Min ◽  
Sung Woo Lee
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Kidney Function ◽  
Thyroid Function ◽  
Direct Effect ◽  
National Health ◽  
Linear Regression Analysis ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Health And Nutrition

Introduction: Thyroid function is evaluated by thyroid stimulating hormone (TSH) and free thyroxine (fT4). Although many studies have indicated an intimate relationship between thyroid hormones and kidney functions, reports about the simultaneous evaluation of TSH and fT4 are rare. Objective: We aimed to analyze the association between TSH and kidney function, with emphasis on a potential nonlinear relationship, and identify an independent relationship between fT4 and kidney function. Methods: We reviewed the data of 7,061 subjects in the Korea National Health and Nutrition Examination Surveys who were randomly subsampled for thyroid function evaluation between 2013 and 2015. A total of 5,578 subjects were included in the final analysis, after excluding people <18 years old, and those with a short fasting time, abnormal fT4 levels, and thyroid disease or related medications. Creatinine-based estimated glomerular filtration rate (eGFR) was used to define kidney function. Results: A 1 mmol/L increase of logarithmic TSH was associated with decreased eGFR (β: –1.8; 95% CI –2.3 to –1.2; p < 0.001), according to multivariate linear regression analysis. On the multivariate generalized additive model plot, TSH demonstrated an L-shaped relationship with eGFR, showing a steeper slope for 0–4 mIU/L of TSH. A 1 µg/dL increase of fT4 was also associated with decreased eGFR (β: –7.0; 95% CI –0.94 to –4.7; p < 0.001) on the multivariate linear regression analysis; this association was reversed after adjusting for age. On the mediation analysis, the indirect effect via age and direct effect per 1 µg/dL increase of fT4 on eGFR was 9.9 (8.1 to 11.7, p < 0.001) and –7.1 (–9.3 to –4.8, p < 0.001), respectively. Conclusions: Increased TSH was associated with decreased eGFR, particularly in the reference range. The direct effect of increased fT4 was decreased eGFR, which may be affected indirectly by age.

Relative contribution of various expressions of cAMP excretion to other indices of parathyroid function, as tested by discriminant multivariate linear regression analysis.

1986 ◽  
Vol 32 (7) ◽  
pp. 1279-1284 ◽  
Author(s):  
J Valsamis ◽  
J Van Peborgh ◽  
H Brauman
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Adenosine Monophosphate ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Amino Terminal ◽  
Relative Contribution ◽  
Parathyroid Function ◽  
Glomerular Filtrate

Abstract We evaluated the relative contribution to the diagnosis of hyperparathyroid disease from current laboratory indices of parathyroid function--plasma calcium (I), phosphate (II), carboxy-terminal (III) and predominantly amino-terminal (IV) radioimmunoassays of parathyrin, the urinary excretion ratios of cyclic adenosine monophosphate (cAMP) to creatinine (V) or to glomerular filtrate (VI), and the ratio of the nephrogenous fraction of cAMP to glomerular filtrate (VII)--in 224 subjects: 40 with surgically proven hyperparathyroid disease, the others normoparathyroid. The decreasing order of sensitivity was I greater than VI greater than VII greater than V greater than III greater than IV greater than II; all these indices differed significantly between normoparathyroid and hyperparathyroid patients. The decreasing order of specificity was VII, III greater than I greater than IV greater than V, II greater than VI. Discriminant multivariate linear regression analysis was performed in a subset of 58 subjects (17 hyper- and 41 normoparathyroid) from the population studied here, chosen because all of the laboratory indices were determined for each subject. The classification accuracy was 98.3% for combining I, VII, and III (r = 0.908), or I and V (r = 0.893), or I and VII (r = 0.889). The other variables did not add to the precision of classification.

scholarly journals Relationship Between Selected Performance Tests and Non-contact Sports Injuries in Male Wushu Players

2020 ◽  
Vol 10 (4) ◽  
pp. 239-249
Author(s):  
Abbas Ghafouri ◽  
◽  
Fariba Mohammadi ◽  
Behnaz Ganji ◽  
◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Lower Extremities ◽  
Analysis Data ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Balance Test ◽  
Limb Injuries ◽  
The Relationship

Purpose: Several tests have been proposed as injury predictor inventories in various sports; however, it is important to recognize which test is more appropriate to predict the injuries of a particular sport. Therefore, the present study aimed to investigate the relationship between selected functional tests and lower limb injuries in elite male wushu athletes. Methods: In total, 40 wushu player were recruited from the national league (Mean±SD age: 25.1±4.9 y, weight: 67.3±7.7 kg, height: 175.3±4.7 cm). Functional Movement Screening (FMS), Tuck jump, single and double leg squats, Star Excursion Balance Test (SEBT), and Stork balance tests were performed in this research. All of the study variables were measured before the national competition, and after the competition, the rate of the injuries were assessed. The correlation between them was evaluated, subsequently. Descriptive data were used to describe the collected results. Besides, multivariate linear regression analysis was used to explore the relationship between the study variables. Results: Multivariate linear regression analysis data suggested that LESS, stroke balance test, single-leg squat, and SEBT failed to predict lower extremities injuries; however, Tuck jump, FMS, and double leg squat could predict lower extremities injuries. Conclusion: Based on the collected results, among the studied tests, trainers and researchers are suggested to employ the Tuck jump, FMS, and double leg squat tests to predict injuries in wushu male players; this test can also be used to prevent injuries in players.

scholarly journals Predictability of 21-Gene Recurrence Score Assay by Using Pathological and Immunohistochemical Parameters in Breast Cancer

2020 ◽  
Vol 14 ◽  
pp. 117822342097784
Author(s):  
Abdulmohsen Alkushi ◽  
Ahmad Omair ◽  
Haitham Arabi ◽  
Emad Masuadi ◽  
Omalkhair Abualkhair
Keyword(s):  
Breast Cancer ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Recurrence Score ◽  
Tumor Grade ◽  
Multivariate Linear Regression ◽  
Oncotype Dx ◽  
Clinicopathological Parameters ◽  
Multivariate Linear Regression Analysis

Background: Oncotype Dx is used to predict the long-term recurrence risk in patients with estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative invasive breast cancer (BC). This study aimed at establishing a correlation between clinicopathological parameters and recurrence score (RS), subsequently improving predictability and ultimately justifying the use of the multigene assay. Materials and methods: A retrospective analysis of the pathology and clinical data of 114 female patients with BC who had Oncotype Dx testing between 2012 and 2019. The pathological parameters included are tumor cell type, tumor grade, pathological stage, and mitotic index (MI). The expression of ER, progesterone receptor (PR), HER2, and Ki67 was assessed by immunohistochemistry. A univariate and multivariate linear regression analysis was performed to assess the correlation between these parameters and the RS. Results: In univariate analysis, age (˂40 years), higher tumor grade, and low PR expression were significantly associated with higher RS ( P = .02; ˂.001; and ˂.001, respectively). Both MI and Ki67 were also strongly correlated with an increase in the RS with a P value of .01 (Spearman correlation 0.34 and 0.33). In multivariate linear regression analysis, age, MI, and Ki67 lost their significance, but both higher grade and PR remained significantly associated with a higher RS along with the tumor stage ( P ˂ .001; ˂.001; and .04, respectively). Conclusions: Tumor grade and PR immunohistochemical expression are the main predictors of RS in our study population. Other clinicopathological features were not significant predictors of change in RS in multivariate analysis.

Abstract MP68: The Correlation Between Left Atrial-left Ventricular-arterial Coupling And Circadian Rhythm Of Blood Pressure In Hypertension

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Yan Liu ◽  
Qiaobing Sun ◽  
Yixiao Zhao ◽  
Yinong Jiang
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Circadian Rhythm ◽  
Linear Regression ◽  
Left Atrial ◽  
Linear Regression Analysis ◽  
Left Ventricular ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Left Ventricular Arterial Coupling

The Correlation between Left Atrial-Left Ventricular-Arterial Coupling and Circadian Rhythm of Blood Pressure in Hypertension Objective: Hypertension induces left atrial (LA) and left ventricular (LV) dysfunction, and arterial stiffness increased. In this study, we further investigated the association between LA-LV-arterial coupling and circadian rhythm of blood pressure (BP) in essential hypertension (HT). Design and Methods: We enrolled 289 HT patients which were evaluated by 2 dimensional speckle tracking echocardiography (2D-STE), ambulatory 24-hour BP monitoring (ABPM) and carotid-femoral pulse wave velocity (PWV). According to BP patterns, these patients were divided into two groups, which included dippers (n=109), patients with a >10% reduction in BP at nighttime; non-dippers (n=180), patients with a <10% reduction in BP at nighttime. 2D-STE based LA and LV strains were studied and the following parameters were measured, LV global longitudinal strain (GLS), LA reservoir strain (LA S-S ), LA conduit strain (LA S-E ), and LA booster pump strain (LA S-A ). LA stiffness index (LASI) defined as the ratio of E/e' to LA S-S , and PWV-to-GLS ratio (PWV/GLS) were calculated to reflect LA-LV-arterial coupling. Furthermore, we also explored the correlation between LASI (or PWV/GLS) and ambulatory blood pressure indexes. The related factors were evaluated by multivariate linear regression analysis to find the independent factors. Results: LASI was significantly higher in non-dippers (0.35±0.24) than dippers (0.29±0.12) ( p <0.05). PWV/GLS was significantly higher in non-dippers (-90.30±34.13) than dippers (-79.62±25.84) ( p <0.05). LA S-S , LA S-A and LV GLS were significantly lower in non-dippers than dippers ( p <0.05). Multivariate linear regression analysis revealed that LV mass index (LVMI), PWV/GLS, nighttime mean SBP (n-SBP) and nighttime mean DBP (n-DBP) were independently correlated with LASI; LASI and n-SBP were independently correlated with PWV/GLS. Conclusions: LA and LV myocardial mechanics, and LA-LV-arterial coupling were associated with circadian rhythm of BP. Nocturnal systolic BP was the independent risk factor of abnormal LA-LV-arterial coupling in HT.

Associations between GDF15 levels and pre-diabetes in non-obese subjects

2021 ◽  
pp. jim-2021-001805
Author(s):  
Hao-Chang Hung ◽  
Hung-Tsung Wu ◽  
Ching-Han Lin ◽  
Hsuan-Wen Chou ◽  
Horng-Yih Ou ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Glucose Tolerance ◽  
Transforming Growth Factor ◽  
Metabolic Diseases ◽  
Linear Regression Analysis ◽  
Transforming Growth Factor Β ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Obese Subjects

Growth differentiation factor 15 (GDF15) is a stress-response cytokine which belongs to the transforming growth factor β superfamily. Although GDF15 was initially found to have a role in metabolic diseases, the association between GDF15 and dysglycemic status remains inconclusive. Thus, the aim of this study was to examine the relationships between GDF15 and different glycemic statuses in non-obese subjects. We enrolled 502 non-obese subjects, among individuals who had normal glucose tolerance (NGT; n=125), isolated impaired fasting glucose (IFG; n=116), isolated impaired glucose tolerance (IGT; n=106), IFG plus IGT (n=27), and newly diagnosed diabetes (NDD; n=128). A multivariate linear regression analysis of GDF15 levels was used to find independent predictors. The median (IQR) GDF15 levels were 1641.0 (1187.0–1985.5) pg/mL, 1656.1 (1226.8–2379.7) pg/mL, 1487.8 (1145.9–1987.2) pg/mL, 1722.2 (1172.9–1939.0) pg/mL, and 2204.5 (1767.4–2919.1) pg/mL in NGT, IFG, IGT, IFG plus IGT, and NDD groups, respectively. The NDD group had significantly higher GDF15 levels than those with NGT, IFG, IGT, and IFG plus IGT. The IFG group had a significantly higher GDF15 value than the NGT group. In multivariate linear regression analysis, IFG (beta=0.145, 95% CI 192.487 to 740.937, p=0.001), NDD (beta=0.227, 95% CI 390.459 to 888.145, p<0.001), and high-sensitivity C reactive protein (beta=0.105, 95% CI 3.276 to 27.768, p=0.013) were independently associated with GDF15 levels. Non-obese subjects with isolated IFG and NDD had significantly higher GDF15 levels than those with NGT. In addition, A1C was independently associated with GDF15 levels. IFG and NDD, but not isolated IGT or IFG plus IGT, were positively associated with GDF15 levels.

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