Ultrafast and continuous-flow synthesis of AFX zeolite via interzeolite conversion of FAU zeolite

2021 ◽  
Vol 6 (1) ◽  
pp. 74-81
Author(s):  
Tatsushi Yoshioka ◽  
Zhendong Liu ◽  
Kenta Iyoki ◽  
Anand Chokkalingam ◽  
Yasuo Yonezawa ◽  
...  
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Secondary Nucleation ◽  
Flow Synthesis ◽  
Fau Zeolite ◽  
Zeolite P

Continuous-flow synthesis of AFX zeolite is achieved with the residence time of 10 min, using FAU zeolite as the silica and alumina source, and acid-leached seeds which promote secondary nucleation of AFX.

Continuous-Flow Synthesis of (–)-Oseltamivir Phosphate (Tamiflu)

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1925-1929 ◽  
Author(s):  
Paul Watts ◽  
Cloudius R. Sagandira
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Shikimic Acid ◽  
Flow Process ◽  
Flow Synthesis ◽  
Continuous Flow Process ◽  
The Individual ◽  
Total Residence Time ◽  
Oseltamivir Phosphate

Herein the anti-influenza drug (–)-oseltamivir phosphate is prepared in continuous flow from ethyl shikimate with 54% overall yield over nine steps and total residence time of 3.5 min from the individual steps. Although the procedure involved intermediate isolation, the dangerous azide chemistry and intermediates involved were elegantly handled in situ. It is the first continuous-flow process for (–)-oseltamivir phosphate involving azide chemistry and (–)-shikimic acid as precursor.

Rapid multigram scale end-to-end continuous flow synthesis of sulfonylurea anti-diabetes drugs: Gliclazide, chlorpropamide and tolbutamide

Synthesis ◽  
2021 ◽  
Author(s):  
Cloudius Sagandira ◽  
Paul Watts
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Sulfonyl Urea ◽  
Flow Processes ◽  
End To End ◽  
Total Residence Time ◽  
Sulfonylurea Drugs

Herein we report multigram scale robust, efficient, and safe end-to-end continuous flow processes for the diabetes sulfonylurea drugs gliclazide, chlorpropamide and tolbutamide. The drugs were prepared via the treatment of an amine with a haloformate affording carbamate which was subsequently treated with a sulfonamide to afford sulfonylurea. Gliclazide was afforded in 87 % yield within 2.5 min total residence time with 26 g/h throughput; 0.2 Kg of the drug was produced in 8 h of running the system continuously. Chlorpropamide and tolbutamide were both afforded in 94 % yield within 1 min residence time with 184-188 g/h throughput; 1.4-1.5 Kg of the drugs was produced in 8 h of running the system continuously. N-substituted carbamates were used as safe alternatives to the hazardous isocyanates in constructing the sulfonyl urea moiety.

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Persistent Luminescent Chromium-Doped Zinc Gallate Nanoparticles

2021 ◽  
pp. 7067-7075
Author(s):  
Xiaojun Wei ◽  
Stephen V. Kershaw ◽  
Xiaodan Huang ◽  
Mingxia Jiao ◽  
Chau Chun Beh ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Zinc Gallate

scholarly journals Continuous flow synthesis of azoxybenzenes by reductive dimerization of nitrosobenzenes with gel‐bound catalysts

2021 ◽  
Author(s):  
Carsten J. Schmiegel ◽  
Patrik Berg ◽  
Franziska Obst ◽  
Roland Schoch ◽  
Dietmar Appelhans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Reductive Dimerization

scholarly journals Continuous Flow Synthesis of Metal–NHC Complexes**

2021 ◽  
Vol 27 (18) ◽  
pp. 5653-5657 ◽  
Author(s):  
Andreas Simoens ◽  
Thomas Scattolin ◽  
Thibault Cauwenbergh ◽  
Gianmarco Pisanò ◽  
Catherine S. J. Cazin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

scholarly journals Continuous‐Flow Synthesis of High‐Quality Few‐Layer Antimonene Hexagons

2021 ◽  
pp. 2101616
Author(s):  
Iñigo Torres ◽  
Marta Alcaraz ◽  
Roger Sanchis‐Gual ◽  
Jose A. Carrasco ◽  
Michael Fickert ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Quality ◽  
Flow Synthesis

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

scholarly journals Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

2020 ◽  
Vol 59 (21) ◽  
pp. 8123-8127 ◽  
Author(s):  
Francesco Carraro ◽  
Jason D. Williams ◽  
Mercedes Linares‐Moreau ◽  
Chiara Parise ◽  
Weibin Liang ◽  
...  
Keyword(s):  
Particle Size ◽  
Continuous Flow ◽  
Flow Synthesis

scholarly journals Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis

ChemSusChem ◽  
2017 ◽  
Vol 10 (17) ◽  
pp. 3435-3444 ◽  
Author(s):  
Tamas Fodi ◽  
Christos Didaskalou ◽  
Jozsef Kupai ◽  
Gyorgy T. Balogh ◽  
Peter Huszthy ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis
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