Continuous reactive crystallization of an API in PFR-CSTR cascade with in-line PATs

2020 ◽  
Vol 5 (10) ◽  
pp. 1950-1962 ◽  
Author(s):  
Chuntian Hu ◽  
Brianna T. Shores ◽  
Rachel A. Derech ◽  
Christopher J. Testa ◽  
Paul Hermant ◽  
...  
Keyword(s):  
Size Distribution ◽  
Crystal Size ◽  
Crystal Size Distribution ◽  
Reactive Crystallization

The influence of PFR on crystal size distribution, reaction and crystallization yields, and supersaturation level was investigated.

scholarly journals Tunable Protein Crystal Size Distribution via Continuous Slug-Flow Crystallization with Spatially Varying Temperature

CrystEngComm ◽  
2021 ◽  
Author(s):  
Nicholas Mozdzierz ◽  
Moo Sun Hong ◽  
Yongkyu Lee ◽  
Moritz Benisch ◽  
Mo Jiang ◽  
...  
Keyword(s):  
Product Quality ◽  
Size Distribution ◽  
Slug Flow ◽  
Crystal Size ◽  
Quality Attributes ◽  
Crystal Size Distribution ◽  
Protein Crystal ◽  
Manufacturing Cost ◽  
Spatially Varying

Accompanied with the growth of the biopharmaceuticals market has been an interest in developing processes with increased control of product quality attributes at low manufacturing cost, with one of the...

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