Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines

Haroon ur Rashid; Marco Antonio Utrera Martines; Adriana Pereira Duarte; Juliana Jorge; Shagufta Rasool; Riaz Muhammad; Nasir Ahmad; Muhammad Naveed Umar

doi:10.1039/d0ra10657g

Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines

RSC Advances ◽

10.1039/d0ra10657g ◽

2021 ◽

Vol 11 (11) ◽

pp. 6060-6098

Author(s):

Haroon ur Rashid ◽

Marco Antonio Utrera Martines ◽

Adriana Pereira Duarte ◽

Juliana Jorge ◽

Shagufta Rasool ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Structure Activity Relationships ◽

Sar Studies ◽

Structure Activity ◽

Recent Developments ◽

Anti Inflammatory

This review sums up recent developments in the syntheses, anti-inflammatory activities, and structure–activity relationship (SAR) studies of pyrimidine derivatives.

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Design, synthesis and structure–activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: Dual activity as cholinesterase and Aβ-aggregation inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.02.030 ◽

2011 ◽

Vol 19 (7) ◽

pp. 2269-2281 ◽

Cited By ~ 25

Author(s):

Tarek Mohamed ◽

Xiaobei Zhao ◽

Lila K. Habib ◽

Jerry Yang ◽

Praveen P.N. Rao

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity ◽

Aβ Aggregation ◽

Aggregation Inhibitors

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Cover Picture: Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a ]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury (ChemMedChem 13/2017)

ChemMedChem ◽

10.1002/cmdc.201700367 ◽

2017 ◽

Vol 12 (13) ◽

pp. 1013-1013

Author(s):

Lingfeng Chen ◽

Yiyi Jin ◽

Weitao Fu ◽

Siyang Xiao ◽

Chen Feng ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Structure Activity Relationship ◽

Inflammatory Activity ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Anti Inflammatory

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Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a ]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury

ChemMedChem ◽

10.1002/cmdc.201700175 ◽

2017 ◽

Vol 12 (13) ◽

pp. 1022-1032 ◽

Cited By ~ 10

Author(s):

Lingfeng Chen ◽

Yiyi Jin ◽

Weitao Fu ◽

Siyang Xiao ◽

Chen Feng ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Structure Activity Relationship ◽

Inflammatory Activity ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Anti Inflammatory

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Antibacterial green tea catechins from a molecular perspective: mechanisms of action and structure–activity relationships

Food & Function ◽

10.1039/d0fo02054k ◽

2020 ◽

Vol 11 (11) ◽

pp. 9370-9396

Author(s):

Andrea Renzetti ◽

Jonathan W. Betts ◽

Kozo Fukumoto ◽

Ryan Noboru Rutherford

Keyword(s):

Green Tea ◽

Structure Activity Relationship ◽

Mechanisms Of Action ◽

Antibacterial Action ◽

Activity Relationship ◽

Tea Catechins ◽

Structure Activity Relationships ◽

Green Tea Catechins ◽

Sar Studies ◽

Structure Activity

This review summarizes the mechanisms of antibacterial action of green tea catechins, discussing the structure–activity relationship (SAR) studies for each mechanism.

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Structure Activity Relationship of Arylidene Pyrrolo and Pyrido [2,1-b] Quinazolones as Cytotoxic Agents: Synthesis, SAR Studies, Biological Evaluation and Docking Studies

Medicinal Chemistry ◽

10.2174/1573406411309050003 ◽

2013 ◽

Vol 9 (5) ◽

pp. 642-650 ◽

Cited By ~ 3

Author(s):

Veenu Mangla ◽

Kunal Nepali ◽

Gagandip Singh ◽

Jagjeet Singh ◽

Santosh Guru ◽

...

Keyword(s):

Structure Activity Relationship ◽

Docking Studies ◽

Biological Evaluation ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity ◽

Relationship Of

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Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.10.037 ◽

2015 ◽

Vol 89 ◽

pp. 21-31 ◽

Cited By ~ 26

Author(s):

Ayyiliath M. Sajith ◽

K.K. Abdul Khader ◽

Nithin Joshi ◽

Manchala Nageswar Reddy ◽

M. Syed Ali Padusha ◽

...

Keyword(s):

Structure Activity Relationship ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity

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Biological Evaluation, Structure−Activity Relationships, and Three-Dimensional Quantitative Structure−Activity Relationship Studies of Dihydro-β-agarofuran Sesquiterpenes as Modulators of P-Glycoprotein-Dependent Multidrug Resistance

Journal of Medicinal Chemistry ◽

10.1021/jm070290v ◽

2007 ◽

Vol 50 (20) ◽

pp. 4808-4817 ◽

Cited By ~ 30

Author(s):

Carolina P. Reyes ◽

Francisco Muñoz-Martínez ◽

Ivan R. Torrecillas ◽

Cristina R. Mendoza ◽

Francisco Gamarro ◽

...

Keyword(s):

Multidrug Resistance ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

P Glycoprotein

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Diffusion of arylpropionate non-steroidal anti-inflammatory drugs into the cerebrospinal fluid: a quantitative structure-activity relationship approach

Fundamental and Clinical Pharmacology ◽

10.1111/j.1472-8206.2004.00201.x ◽

2004 ◽

Vol 18 (1) ◽

pp. 65-70 ◽

Cited By ~ 21

Author(s):

Fabienne Pehourcq ◽

Myriam Matoga ◽

Bernard Bannwarth

Keyword(s):

Cerebrospinal Fluid ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Anti-inflammatory Properties of an Active Sesquiterpene Lactone and its Structure-Activity Relationship

Medicinal Chemistry ◽

10.4172/2161-0444.1000286 ◽

2015 ◽

Author(s):

Yang Hu

Keyword(s):

Sesquiterpene Lactone ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Anti Inflammatory

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Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽

10.1039/c7ra00422b ◽

2017 ◽

Vol 7 (30) ◽

pp. 18681-18689 ◽

Cited By ~ 2

Author(s):

De-Chun Chang ◽

Yi-Mei Zhang ◽

Ji Zhang ◽

Yan-Hong Liu ◽

Xiao-Qi Yu

Keyword(s):

Gene Delivery ◽

Structure Activity Relationship ◽

Cationic Lipids ◽

Activity Relationship ◽

Viral Gene ◽

Structure Activity Relationships ◽

Structure Activity ◽

Gene Delivery Vectors ◽

Gene Vectors ◽

Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

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