scholarly journals Two methods for the preparation of sitagliptin phosphate via chemical resolution and asymmetric hydrogenation

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4805-4809
Author(s):  
Fei Ye ◽  
Zhifeng Zhang ◽  
Wenxia Zhao ◽  
Jianhai Ding ◽  
Yali Wang ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Chemical Resolution

Two effective processes have been developed for the preparation of sitagliptin phosphate.

scholarly journals Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 211-226 ◽  
Author(s):  
Perla Ramesh ◽  
Devatha Suman ◽  
Koti Reddy
Keyword(s):  
Asymmetric Reduction ◽  
Asymmetric Hydrogenation ◽  
Asymmetric Aldol ◽  
Asymmetric Michael Addition ◽  
Chemical Resolution ◽  
Enzymatic Desymmetrization ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Synthetic Approaches ◽  
Catalytic Asymmetric Hydrogenation

Baclofen is an antispastic drug used as a muscle relaxant in the treatment of the paroxysmal pain of trigeminal neuralgia, spasticity of the spinal cord and cerebral origin. Baclofen resides biological activity exclusively in its (R)-(–)-enantiomer. In this review, various asymmetric synthetic strategies for (R)-(–)-baclofen are described.1 Introduction2 Resolution Synthetic Approaches2.1 Chemical Resolution2.2 Biocatalytic Resolution3 Asymmetric Desymmetrization3.1 Catalytic Enantioselective Desymmetrization3.2 Enzymatic Desymmetrization4 Chiral Auxiliary Induced Asymmetric Synthesis4.1 Asymmetric Michael Addition4.2 Asymmetric Aldol Addition4.3 Asymmetric Nucleophilic Substitution5 Asymmetric Reduction5.1 Catalytic Asymmetric Hydrogenation5.2 Bioreduction6 Catalytic Asymmetric Conjugate Addition7 Conclusion

Asymmetric Hydrogenation of Benzalacetone Catalyzed by RuCl2 (TPPTS) 2-(S,S)-DPENDS in Water Medium

2010 ◽  
Vol 31 (3) ◽  
pp. 273-277
Author(s):  
Jinbo WANG ◽  
Ruixiang QIN ◽  
Wei XIONG ◽  
Yun JIA ◽  
Derong LIU ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Water Medium

Reaction Mechanisms of Inorganic and Organometallic Systems

2007 ◽  
Author(s):  
Robert B. Jordan
Keyword(s):  
Electron Transfer ◽  
Heterogeneous Systems ◽  
Asymmetric Hydrogenation ◽  
Pressure Effects ◽  
General Level ◽  
Hydrogenation Catalysts ◽  
Methyl Transferase ◽  
Transfer Region ◽  
Previous Edition ◽  
Oxide Synthase

This third edition retains the general level and scope of earlier editions, but has been substantially updated with over 900 new references covering the literature through 2005, and 140 more pages of text than the previous edition. In addition to the general updating of materials, there is new or greatly expanded coverage of topics such as Curtin-Hammett conditions, pressure effects, metal hydrides and asymmetric hydrogenation catalysts, the inverted electron-transfer region, intervalence electron transfer, photochemistry of metal carbonyls, methyl transferase and nitric oxide synthase. The new chapter on heterogeneous systems introduces the basic background to this industrially important area. The emphasis is on inorganic examples of gas/liquid and gas/liquid/solid systems and methods of determining heterogeneity.

Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones

2003 ◽  
Vol 125 (15) ◽  
pp. 4404-4405 ◽  
Author(s):  
Jian-Hua Xie ◽  
Li-Xin Wang ◽  
Yu Fu ◽  
Shuo-Fei Zhu ◽  
Bao-Min Fan ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation

Enantioselective Synthesis of Chiral Tetrahydroisoquinolines by Iridium-Catalyzed Asymmetric Hydrogenation of Enamines

2009 ◽  
Vol 351 (18) ◽  
pp. 3243-3250 ◽  
Author(s):  
Pu-Cha Yan ◽  
Jian-Hua Xie ◽  
Guo-Hua Hou ◽  
Li-Xin Wang ◽  
Qi-Lin Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Synthesis
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