scholarly journals Current advances in nanomaterials affecting morphology, structure, and function of erythrocytes

RSC Advances ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 6958-6971
Author(s):  
Yaxian Tian ◽  
Zhaoju Tian ◽  
Yanrong Dong ◽  
Xiaohui Wang ◽  
Linsheng Zhan

This review focuses on the way how nanoparticles affect the structure and function of erythrocyte membranes, and is expected to pave the way for development of new nanodrugs.

1977 ◽  
Vol 165 (1) ◽  
pp. 157-161 ◽  
Author(s):  
M J A Tanner ◽  
D J Anstee ◽  
P A Judson

1. We investigated the membranes of human erythrocytes which completely lack the blood-group antigens S and s (denoted as S-s-) as part of a study of the structure and function of the surface glycoproteins of the human erythrocyte. 2. The S-s-erythrocyte-membrane glycoprotein PAS-3 band was much less intensely stained in comparison with that of the glycoprotein from normal erythrocyte membranes. The S-s-membrane glycoprotein PAS-4 band also showed decreased staining. 3. Examination with the lectins from Maclura aurantiaca (Osage orange) and Arachis hypogaea (groundnut) showed that the PAS-3 glycoprotein of S-s-erythrocyte membranes lacked the receptors for these lectins that are present on glycoprotein PAS-3 from normal erythrocytes. 4. Radioiodination with lactoperoxidase showed the presence of the polypeptide of glycoprotein PAS-3 in S-s-cells, although it was more weakly labelled than the protein in the normal erythrocyte. 5. Our results show that the PAS-3 glycoprotein of S-s-erythrocytes is deficient in some of the carbohydrates present in the protein from normal erythrocytes. Glycoprotein PAS-4 of normal erythrocytes is shown to be a complex containing both glycoproteins PAS-1 and PAS-3.


2007 ◽  
Vol 23 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Brian Dolan

✓Anatomical and physiological understandings of the structure and function of the brain have worked to establish it as the “seat of the soul.” As an organ of reflection, meditation, and memory, the brain becomes synonymous with what defines the “self” through the existence of consciousness—of mind. Thus, the brain has been associated with a range of transcendent concepts—the soul, spirit, mind, and consciousness—that all relate in fundamental ways to each other both in terms of their perceived location within the brain and because of the way each works ultimately to define the person to whom the brain belongs. In this article, the author provides a brief exploration of how interrelated these categories have been when seen in the context of ancient, Renaissance, early modern, and modern philosophical and medical concerns; how the brain has variously been perceived as home to these intimate states of being; and how practitioners from the neurosciences have reflected on these questions. The author provides novel insights into the interrelationships of philosophy, theology, and medicine by examining these issues through the lens of the history of neuroscience.


2020 ◽  
pp. 100-132
Author(s):  
Alan McHughen

Armed with knowledge of DNA structure and function, this book can now shift to applying knowledge of DNA and genetics to practical issues. Many of these are covered in social and mass media, often unsatisfactorily citing DNA as a key player but failing to reveal how DNA achieved the objectives. This chapter shows the mechanisms by which DNA and genetics answered the questions. It starts with what is likely the most dramatic, the forensic use of DNA in identifying criminals, followed by other situations in which DNA is used to identify people and wrapping up with examples of DNA clearing up some historical mysteries. Along the way some limitations to DNA technology in identifying specific people is considered, as well as some potential impacts on personal privacy.


1997 ◽  
Vol 53 (3) ◽  
Author(s):  
J. H. Roberts

The confessional statement Colossians 1:13-20: Unity, structure and function. Scholarly work has concentrated much effort on Colossians 1:15-20 as an early Christian hymn. In discussions with Botha (1986; 1989) and Van der Watt (1988), an attempt has been made here to prove the unity of 1 :13-20 as a confessional statement, and to determine its structural coherence and progression. The letter's macro structure is utilized to pinpoint the pericope's locality in the letter since this has bearing on the function it fulfills. The analysis of its structural composition is an attempt to help clarify my position on various details and understanding of its meaning. In view of the positions taken and of a discussion of the letter's context and its communicative thrust, the function of the confessional statement is considered to be its role of grounding the community's faith in the totally sufficient salvation by God in Christ thus opening the way for the warning against being misled on a way other than that of Christ and to hold onto him as head, which signals the communicative thrust of the letter.


Blood ◽  
1995 ◽  
Vol 86 (11) ◽  
pp. 4315-4322 ◽  
Author(s):  
R Winardi ◽  
D Discher ◽  
C Kelley ◽  
L Zon ◽  
K Mays ◽  
...  

A developmental alternative splicing switch, involving exon 16 of protein 4.1 pre-mRNA, occurs during mammalian erythropoiesis. By controlling expression of a 21-amino acid peptide required for high- affinity interaction of protein 4.1 with spectrin and actin, this switch helps to regulate erythrocyte membrane mechanical stability. Here we show that key aspects of protein 4.1 structure and function are conserved in nucleated erythroid cells of the amphibian Xenopus laevis. Analysis of protein 4.1 cDNA sequences cloned from Xenopus erythrocytes and oocytes showed that tissue-specific alternative splicing of exon 16 also occurs in frogs. Importantly, functional studies with recombinant Xenopus erythroid 4.1 demonstrated specific binding to and mechanical stabilization of 4.1-deficient human erythrocyte membranes. Phylogenetic sequence comparison showed two evolutionarily conserved peptides that represent candidate spectrin-actin binding sites. Finally, in situ hybridization of early embryos showed high expression of 4.1 mRNA in ventral blood islands and in developing brain structures. These results demonstrate that regulated expression of structurally and functionally distinct protein 4.1 isoforms, mediated by tissue-specific alternative splicing, has been highly evolutionarily conserved. Moreover, both nucleated amphibian erythrocytes and their enucleated mammalian counterparts express 4.1 isoforms functionally competent for spectrin-actin binding.


Author(s):  
Peter Sterling

The synaptic connections in cat retina that link photoreceptors to ganglion cells have been analyzed quantitatively. Our approach has been to prepare serial, ultrathin sections and photograph en montage at low magnification (˜2000X) in the electron microscope. Six series, 100-300 sections long, have been prepared over the last decade. They derive from different cats but always from the same region of retina, about one degree from the center of the visual axis. The material has been analyzed by reconstructing adjacent neurons in each array and then identifying systematically the synaptic connections between arrays. Most reconstructions were done manually by tracing the outlines of processes in successive sections onto acetate sheets aligned on a cartoonist's jig. The tracings were then digitized, stacked by computer, and printed with the hidden lines removed. The results have provided rather than the usual one-dimensional account of pathways, a three-dimensional account of circuits. From this has emerged insight into the functional architecture.


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