scholarly journals Targeting self-assembled F127-peptide polymer with pH sensitivity for release of anticancer drugs

RSC Advances ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 1461-1471
Author(s):  
Wenzhao Han ◽  
Fanwei Meng ◽  
Hao Gan ◽  
Feng Guo ◽  
Junfeng Ke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Anticancer Drugs ◽  
Ph Sensitivity ◽  
Chemotherapy Drugs ◽  
Self Assembled

The treatment of breast cancer mainly relies on chemotherapy drugs, which present significant side effects.

An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy

2018 ◽  
Vol 42 (5) ◽  
pp. 3828-3832 ◽  
Author(s):  
Seyed A. R. Alavi-Tabari ◽  
Mohammad A. Khalilzadeh ◽  
Hassan Karimi-Maleh ◽  
Daryoush Zareyee
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Breast Cancer Therapy ◽  
Chemotherapy Drugs

Epirubicin (EB) and topotecan (TP) are two major anticancer drugs that are used in breast cancer therapy with many side effects.

scholarly journals The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1212
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Drug Resistance ◽  
Side Effects ◽  
Anticancer Drugs ◽  
Drug Toxicity ◽  
Multi Drug Resistance ◽  
Drug Bioavailability

Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery systems that can overcome the limitations associated with the currently used anticancer drugs. They have the capability to overcome drug resistance, reduce drug toxicity, improve the drug solubility and bioavailability. Different classes of anticancer drugs have been loaded into micelles and dendrimers, resulting in targeted drug delivery, sustained drug release mechanism, increased cellular uptake, reduced toxic side effects of the loaded drugs with enhanced anticancer activity in vitro and in vivo. This review article reports the biological outcomes of dendrimers and micelles loaded with different known anticancer agents on breast cancer in vitro and in vivo.

Chlorambucil-Chitosan Nano-conjugate: An efficient Agent against Breast Cancer Targeted Therapy

2020 ◽  
Vol 17 ◽  
Author(s):  
Azadeh Shayegh ◽  
Farinaz Khalatbari ◽  
Niloofar Zonoubi ◽  
Farjad Zarazvand ◽  
Fatemeh Monavvari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Biological Effects ◽  
Rt Pcr ◽  
Chemotherapy Drugs ◽  
Anti Cancer ◽  
Afm Analysis ◽  
Cancer Targeted Therapy ◽  
Mcf 7

Background: Discovering new chemotherapy drugs and techniques with the least side effects is one of the most important and challenging world issues in recent years. Chlorambucil is an anticancer drug that is still commonly used as a primary treatmentin at treatment of some cancers, but it can cause side effects. Objective: In this study, we decided to use chitosan as a carrier for enhance the uptake of chlorambucil and reduce the toxicity of this drug. Method: After producing this nanoconjugate compound and analysing its structure by FTIR, DLS and AFM analysis, we investigated the therapeutic and biological effects of this nanoconjugate compound on the MCF-7 cell line (breast cancer). Results: The results of the MTT assay showed that this nanoconjugate compound not only retained its anti-cancer effect against chlorambucil but also showed less abnormal toxicity. Also, In vitro cellular uptake by flow cytometry indicated the better uptake final product into the MCF-7 cells. The detection of apoptosis induced cell death was confirmed by RT-PCR. Conclusion: This study has created a prospective pathway for targeting cancer cells using chitosan.

scholarly journals Evaluation of Drug Side Effects Chemotherapy on Quality of Life (QOL) Breast Cancer Patients at Hospital X in Jakarta

2019 ◽  
Vol 17 (1) ◽  
pp. 9
Author(s):  
Sondang Khairani ◽  
Sesilia A Keban ◽  
Meyke Afrianty
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Side Effects ◽  
Cancer Patients ◽  
Sampling Technique ◽  
Cancer Type ◽  
Drug Side Effects ◽  
Breast Cancer Patients ◽  
Chemotherapy Drugs

Breast cancer is the number one cancer type discovered at women in the world. Most causes are genetic factors and hormonal factors. One cancer treatments with chemotherapy. Chemotherapy drugs active in cells dividing and reproducing, but cells normally to be affected by chemotherapy and side effects from chemotherapy drugs affect quality of life. The aim of the study to evaluate side effects of chemotherapy drugs on the quality of life of breast cancer patients. Sampling technique observational prospective breast cancer patients with completed the chemotherapy cycle from September 2017 to April 2018 with descriptive analysis and statistics by looking correlation between drug side effects and Quality of Life (QoL). Results of the study were side effects of fatigue 100%, nausea 67,5%, vomiting 60%, no appetite 63,75%, fever 42,5%, joint pain 43,75%, diarrhea 16,25%, difficulty swallowing 16,25%, allergies 5%, itching 1,25%, mouth sores 3,75%, swollen right hand 1,25%, constipation 3,75%. QoL results are physical 6,2%; psychology 5,3%; social 4,9%; spiritual 6,8%. Results of Sperman test showed no correlation between the side effects of chemotherapy and QoL P> 0,05. This study shows that there is no relationship between the side effects drug chemotherapy and QoL in breast cancer patients.

scholarly journals Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer: Preparation and In Vitro Assessment

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sana Abbasi ◽  
Arghya Paul ◽  
Wei Shao ◽  
Satya Prakash
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Serum Albumin ◽  
Anticancer Drugs ◽  
Antineoplastic Agent ◽  
In Vitro Assessment ◽  
Nanoparticle Formulation ◽  
Treat Breast Cancer ◽  
Effective Carrier

Most anticancer drugs are greatly limited by the serious side effects that they cause. Doxorubicin (DOX) is an antineoplastic agent, commonly used against breast cancer. However, it may lead to irreversible cardiotoxicity, which could even result in congestive heart failure. In order to avoid these harmful side effects to the patients and to improve the therapeutic efficacy of doxorubicin, we developed DOX-loaded polyethylenimine- (PEI-) enhanced human serum albumin (HSA) nanoparticles. The formed nanoparticles were ~137 nm in size with a surface zeta potential of ~+15 mV, prepared using 20 μg of PEI added per mg of HSA. Cytotoxicity was not observed with empty PEI-enhanced HSA nanoparticles, formed with low-molecular weight (25 kDa) PEI, indicating biocompatibility and safety of the nanoparticle formulation. Under optimized transfection conditions, approximately 80% of cells were transfected with HSA nanoparticles containing tetramethylrhodamine-conjugated bovine serum albumin. Conclusively, PEI-enhanced HSA nanoparticles show potential for developing into an effective carrier for anticancer drugs.

scholarly journals Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4400
Author(s):  
Ali Sartaj ◽  
Zufika Qamar ◽  
Farheen Fatima Qizilbash ◽  
Annu ◽  
Shadab Md ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Polymeric Nanoparticles ◽  
Breast Cancer Treatment ◽  
Chemotherapeutic Agents ◽  
First Line ◽  
Chemotherapy Drugs ◽  
Polymeric Nanoparticle

This manuscript aims to provide the latest update on polymeric nanoparticle drug delivery system for breast cancer treatment after 2015 and how research-oriented it is based on the available research data. Therefore, the authors have chosen breast cancer which is the most frequent and common reason for mortality in women worldwide. The first-line treatment for breast cancer treatment is chemotherapy, apart from surgery, radiation and hormonal therapy. Chemotherapy is associated with lesser therapeutics and undesirable side effects and hence. In addition, drug resistance affects the therapeutic dose to the target site. Although various nano-based formulations have been developed for effective treatment, the polymeric nanoparticles effectively avoid the lacunae of conventional chemotherapy. There has been an effort made to understand the chemotherapy drugs and their conventional formulation-related problems for better targeting and effective drug delivery for breast cancer treatment. Thus, the polymeric nanoparticles as a strategy overcome the associated problems with resulting dose reduction, enhanced bioavailability, reduced side effects, etc. This present review has compiled the research reports published from 2015 to 2021 from different databases, such as PubMed, Google Scholar, ScienceDirect, which are related to breast cancer treatment in which the drug delivery of numerous chemotherapeutic agents alone or in combination, including phytoconstituents formulated into various polymer-based nanoparticles.

scholarly journals DOX-loaded pH-sensitive mesoporous silica nanoparticles coated with PDA and PEG induce pro-death autophagy in breast cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (63) ◽  
pp. 39641-39650 ◽  
Author(s):  
Yanhong Duo ◽  
Yang Li ◽  
Changke Chen ◽  
Baiyun Liu ◽  
Xinyu Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Uptake ◽  
Uptake Efficiency ◽  
Chemotherapy Drugs ◽  
Nano Drug Delivery

The development of multifunctional nano drug delivery carriers has been one of the most effective and prevailing approaches to overcome drug non-selectivity, low cell uptake efficiency and various side effects of traditional chemotherapy drugs.

scholarly journals Cytotoxic Effect of Two Novel Platinum (II) Complexes on Breast Cancer: An in Vitro Study

2018 ◽  
Vol 3 (2) ◽  
pp. 47-50
Author(s):  
Samad Akbarzadeh ◽  
Fatemeh Ebrahimi ◽  
Zeinab Faghih ◽  
Ali Movahed ◽  
Zahra Faghih
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cell Lines ◽  
Cytotoxic Effect ◽  
Acquired Resistance ◽  
In Vitro Study ◽  
Cytotoxic Activities ◽  
Breast Cancer Patients ◽  
Chemotherapy Drugs

Background: With 1.36 million new cases in worldwide each year, breast cancer (BC) is the most common malignancy in the female. Among numerous chemotherapy drugs which are widely used for cancer therapy, platinum compounds are the most persuasive ones although challenges remain with the clinical use of them due to their side effects as well as intrinsic and acquired resistance. In the attempt to combat drug resistance, reduce cytotoxic side effects or find the drug for particular forms of cancer, over the years, thousands of other platinum (Pt) compounds i.e. carboplatin and oxaliplatin have been developed.Material and Methods: In this regard, we previously described the synthesis of some new platinum (II) derivatives with potential anti-cancer activities against BC. Here, we chose two of the best platinum(II) compounds, 3b and 2a, to further evaluate their cytotoxic activities against human BC cell lines, SKBR3, MCF-7, MDA-MB-231, and MBA-MB-468, with different molecular subtypes using a colorimetric MTT cytotoxic assay. Their cytotoxic activities were compared to cis-platin as a positive control. Results: Our result showed that both compounds had better cytotoxic effect against BC cell lines than cis-platin in particular in the case of triple-negative subtype.Conclusion: These results suggest these compounds as potentially valuable agents for the treatment of breast cancer patients.

scholarly journals The Potential of Ultrasound Technology and Chemotherapy Carriers in Breast Cancer Treatment

2018 ◽  
Author(s):  
Ghaleb Husseini ◽  
Yassmine Abbas ◽  
Nahid Awad
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
United Arab Emirates ◽  
Breast Cancer Treatment ◽  
Ultrasonic Waves ◽  
Chemotherapy Drugs ◽  
Policy Paper ◽  
Ultrasound Technology ◽  
Cancerous Cells

In the United Arab Emirates (UAE), breast cancer is the leading cause of death among women, and chemotherpy is widly used to treat it. However, chemotherapy drugs are not able to differentiate between the cancerous and healthy tissues. This leads to the well-known, harmful side effects of this treatment, which include hair loss, fatigue, nausea, and a weakened immune system. This paper argues for the potential effectiveness of delivering chemotherapy drugs to tumors in protective barriers (drug encapsulation in a nano-carrier) that isolate the drug from healthy tissues, minimizing side effects and increasing the quality of life of patients and their families. When injected into the bloodstream, these nanocarriers will diffuse into the tumor and ultrasonic waves can then be administered at the tumor site in order to release the chemotherapy drug from its capsule. This will restrict the drug to the physical location of the cancerous cells. This policy paper offers a number of recommendations related to furthering this research for the benefit of UAE citizens, residents, and those impacted by breast cancer around the world.

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