scholarly journals Rapid structural regulation, apatite-inducing mechanism and in vivo investigation of microwave-assisted hydrothermally treated titania coating

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7305-7317
Author(s):  
Lin Chen ◽  
Junyu Ren ◽  
Narisu Hu ◽  
Qing Du ◽  
Daqing Wei
Keyword(s):  
Crucial Role ◽  
Microwave Assisted ◽  
Nano Scale ◽  
Structural Regulation ◽  
Scale Structures ◽  
Titania Coating

In this work, the micro/nano scale structures of HA nanorods integrated on a titanium were prepared using MAO and MH treatment. The in vivo results indicate that HA crystals play a crucial role in the improvement of the osseointegration.

scholarly journals EBV-LMP1 promotes radioresistance by inducing protective autophagy through BNIP3 in nasopharyngeal carcinoma

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
San Xu ◽  
Zhuan Zhou ◽  
Xingzhi Peng ◽  
Xuxiu Tao ◽  
Peijun Zhou ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Crucial Role ◽  
Epstein Barr Virus ◽  
Interacting Protein ◽  
Multiple Tumors ◽  
Barr Virus ◽  
Signaling Axis ◽  
Epstein Barr ◽  
Adenovirus E1b

AbstractStudies have indicated that dysfunction of autophagy is involved in the initiation and progression of multiple tumors and their chemoradiotherapy. Epstein–Barr virus (EBV) is a lymphotropic human gamma herpes virus that has been implicated in the pathogenesis of nasopharyngeal carcinoma (NPC). EBV encoded latent membrane protein1 (LMP1) exhibits the properties of a classical oncoprotein. In previous studies, we experimentally demonstrated that LMP1 could increase the radioresistance of NPC. However, how LMP1 contributes to the radioresistance in NPC is still not clear. In the present study, we found that LMP1 could enhance autophagy by upregulating the expression of BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3). Knockdown of BNIP3 could increase the apoptosis and decrease the radioresistance mediated by protective autophagy in LMP1-positive NPC cells. The data showed that increased BNIP3 expression is mediated by LMP1 through the ERK/HIF1α signaling axis, and LMP1 promotes the binding of BNIP3 to Beclin1 and competitively reduces the binding of Bcl-2 to Beclin1, thus upregulating autophagy. Furthermore, knockdown of BNIP3 can reduce the radioresistance promoted by protective autophagy in vivo. These data clearly indicated that, through BNIP3, LMP1 induced autophagy, which has a crucial role in the protection of LMP1-positive NPC cells against irradiation. It provides a new basis and potential target for elucidating LMP1-mediated radioresistance.

scholarly journals On the Formation of Lipid Nano-Scale Structures at Interfaces Beyond Planar Bilayers

2016 ◽  
Vol 110 (3) ◽  
pp. 189a
Author(s):  
Aleksandra Dabkowska ◽  
Cassandra Niman ◽  
Gaelle Offranc Piret ◽  
Henrik Persson ◽  
Hanna Wacklin ◽  
...  
Keyword(s):  
Planar Bilayers ◽  
Nano Scale ◽  
Scale Structures

Crucial role of lysosomal iron in the formation of dinitrosyl iron complexes in vivo

2006 ◽  
Vol 12 (3) ◽  
pp. 345-352 ◽  
Author(s):  
Hanna Lewandowska ◽  
Sylwia Męczyńska ◽  
Barbara Sochanowicz ◽  
Jarosław Sadło ◽  
Marcin Kruszewski
Keyword(s):  
Crucial Role ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

scholarly journals An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly

2017 ◽  
Vol 45 (14) ◽  
pp. 8474-8483 ◽  
Author(s):  
Lucas Philippe ◽  
George C. Pandarakalam ◽  
Rotimi Fasimoye ◽  
Neale Harrison ◽  
Bernadette Connolly ◽  
...  
Keyword(s):  
Crucial Role ◽  
De Novo ◽  
Genetic Screen ◽  
Spliced Leader ◽  
Trans Splicing

scholarly journals Nano-scale architecture of blood-brain barrier tight-junctions

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Esther Sasson ◽  
Shira Anzi ◽  
Batia Bell ◽  
Oren Yakovian ◽  
Meshi Zorsky ◽  
...  
Keyword(s):  
Tight Junctions ◽  
Blood Brain Barrier ◽  
Super Resolution ◽  
Brain Barrier ◽  
Molecular Architecture ◽  
Mouse Development ◽  
Nano Scale ◽  
Blood Brain ◽  
Structural And Functional Properties

Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related to several neurodegenerative diseases. What makes these highly specialized BBB-TJs extremely restrictive remains unknown. Here, we use super-resolution microscopy (dSTORM) to uncover new structural and functional properties of BBB TJs. Focusing on three major components, Nano-scale resolution revealed sparse (occludin) vs. clustered (ZO1/claudin-5) molecular architecture. In mouse development, permeable TJs become first restrictive to large molecules, and only later to small molecules, with claudin-5 proteins arrangement compacting during this maturation process. Mechanistically, we reveal that ZO1 clustering is independent of claudin-5 in-vivo. In contrast to accepted knowledge, we found that in the developmental context, total levels of claudin-5 inversely correlate with TJ functionality. Our super-resolution studies provide a unique perspective of BBB TJs and open new directions for understanding TJ functionality in biological barriers, ultimately enabling restoration in disease or modulation for drug delivery.

scholarly journals Comparing the Efficacy of Three Different Nano-scale Bone Substitutes: In vivo Study

2017 ◽  
Vol 6 (1) ◽  
pp. 64 ◽  
Author(s):  
Saied Nosouhian ◽  
SayedMohammad Razavi ◽  
Mansour Rismanchian ◽  
Nasim Jafari-pozve
Keyword(s):  
Bone Substitutes ◽  
In Vivo Study ◽  
Nano Scale

scholarly journals Kruppel-like factor 4 regulates neutrophil activation

2017 ◽  
Vol 1 (11) ◽  
pp. 662-668 ◽  
Author(s):  
Yuyan Shen ◽  
Hong Hong ◽  
Panjamaporn Sangwung ◽  
Stephanie Lapping ◽  
Lalitha Nayak ◽  
...  
Keyword(s):  
Crucial Role ◽  
Neutrophil Function ◽  
Neutrophil Activation ◽  
Key Points

Key Points KLF4 deficiency impairs neutrophil function in vitro and in vivo. This is the first demonstration that KLF4 plays a crucial role in neutrophils.

scholarly journals Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo

2019 ◽  
Vol 10 ◽  
Author(s):  
Anna Hafner ◽  
Ulrike Kolbe ◽  
Isabel Freund ◽  
Virginia Castiglia ◽  
Pavel Kovarik ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Streptococcus Pyogenes ◽  
Crucial Role ◽  
Toll Like Receptors
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