scholarly journals Electrospun collagen core/poly-l-lactic acid shell nanofibers for prolonged release of hydrophilic drug

RSC Advances ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 5703-5711
Author(s):  
Wan-Ying Huang ◽  
Toshiya Hibino ◽  
Shin-ichiro Suye ◽  
Satoshi Fujita
Keyword(s):  
Lactic Acid ◽  
Core Shell ◽  
Prolonged Release ◽  
Hydrophilic Drugs ◽  
Hydrophilic Drug ◽  
Polymer Miscibility ◽  
Hydrophobic Shell

A hydrophilic drug was encapsulated in nanofibers with hydrophobic shell using core–shell electrospinning. Drug–polymer miscibility affected the crystallinity of drug-loaded nanofibers. Our results propose a way to prolong the release of hydrophilic drugs from nanofibers.

scholarly journals Development of Hydrophilic Drug Encapsulation and Controlled Release Using a Modified Nanoprecipitation Method

Processes ◽  
2019 ◽  
Vol 7 (6) ◽  
pp. 331
Author(s):  
Jiang Xu ◽  
Yuyan Chen ◽  
Xizhi Jiang ◽  
Zhongzheng Gui ◽  
Lei Zhang
Keyword(s):  
Lactic Acid ◽  
Controlled Release ◽  
Drug Loading ◽  
Continuous Phase ◽  
Poly Lactic Acid ◽  
Feed Concentration ◽  
Hydrophilic Drugs ◽  
Hydrophilic Drug ◽  
Nanoprecipitation Method

The improvement of the loading content of hydrophilic drugs by polymer nanoparticles (NPs) recently has received increased attention from the field of controlled release. We developed a novel, simply modified, drop-wise nanoprecipitation method which separated hydrophilic drugs and polymers into aqueous phase (continuous phase) and organic phase (dispersed phase), both individually and involving a mixing process. Using this method, we produced ciprofloxacin-loaded NPs by Poly (d,l-lactic acid)-Dextran (PLA-DEX) and Poly lactic acid-co-glycolic acid-Polyethylene glycol (PLGA-PEG) successfully, with a considerable drug-loading ability up to 27.2 wt% and an in vitro sustained release for up to six days. Drug content with NPs can be precisely tuned by changing the initial drug feed concentration of ciprofloxacin. These studies suggest that this modified nanoprecipitation method is a rapid, facile, and reproducible technique for making nano-scale drug delivery carriers with high drug-loading abilities

Fabrication of core-shell structured nanofibers of poly (lactic acid) and poly (vinyl alcohol) by coaxial electrospinning for tissue engineering

2018 ◽  
Vol 98 ◽  
pp. 483-491 ◽  
Author(s):  
Hamad F. Alharbi ◽  
Monis Luqman ◽  
Khalil Abdelrazek Khalil ◽  
Yasser A. Elnakady ◽  
Omar H. Abd-Elkader ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Vinyl Alcohol ◽  
Poly Lactic Acid ◽  
Poly Vinyl Alcohol ◽  
Coaxial Electrospinning ◽  
Core Shell

Colloidal Stability of Magnetite/Poly(lactic acid) Core/Shell Nanoparticles

Langmuir ◽  
2006 ◽  
Vol 22 (6) ◽  
pp. 2816-2821 ◽  
Author(s):  
Salvador A. Gómez-Lopera ◽  
José L. Arias ◽  
Visitación Gallardo ◽  
Ángel V. Delgado
Keyword(s):  
Lactic Acid ◽  
Colloidal Stability ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core–shell nanoparticles as a stimuli-responsive drug delivery system

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Ayae Sugawara-Narutaki ◽  
Katsuya Kato ◽  
Fukue Nagata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Delivery Systems ◽  
Ph Sensitivity ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Shell Nanoparticles ◽  
The Core ◽  
Core Shell Nanoparticles

Biodegradable nanoparticles have been well studied as biocompatible delivery systems. Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to tumour tissues and their accumulation therein via the enhanced permeability and retention (EPR) effect. Recent studies have focused on stimuli-responsive drug delivery systems (DDS) for improving the effectiveness of chemotherapy; for example, pH-sensitive DDS depend on the weakly acidic and neutral extracellular pH of tumour and normal tissues, respectively. In our previous work, core–shell nanoparticles composed of the biodegradable polymer poly(lactic acid) (PLA) and the widely used inorganic biomaterial hydroxyapatite (HAp, which exhibits pH sensitivity) were prepared using a surfactant-free method. These PLA/HAp core–shell nanoparticles could load 750 wt% of a hydrophobic model drug. In this work, the properties of the PLA/HAp core–shell nanoparticles loaded with the anti-cancer drug paclitaxel (PTX) were thoroughly investigated in vitro . Because the PTX-containing nanoparticles were approximately 80 nm in size, they can be expected to facilitate efficient drug delivery via the EPR effect. The core–shell nanoparticles were cytotoxic towards cancer cells (4T1). This was due to the pH sensitivity of the HAp shell, which is stable in neutral conditions and dissolves in acidic conditions. The cytotoxic activity of the PTX-loaded nanoparticles was sustained for up to 48 h, which was suitable for tumour growth inhibition. These results suggest that the core–shell nanoparticles can be suitable drug carriers for various water-insoluble drugs.

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