scholarly journals Formulation development, in vitro and in vivo evaluation of chitosan engineered nanoparticles for ocular delivery of insulin

RSC Advances ◽  
2020 ◽  
Vol 10 (71) ◽  
pp. 43629-43639
Author(s):  
Priyanka Rathore ◽  
Alok Mahor ◽  
Surendra Jain ◽  
Anzarul Haque ◽  
Prashant Kesharwani
Keyword(s):  
Engineered Nanoparticles ◽  
Diabetic Patients ◽  
Ocular Delivery ◽  
Formulation Development ◽  
In Vivo Evaluation ◽  
Insulin Dependent ◽  
Development In Vitro ◽  
Insulin Dependent Diabetic

Insulin-dependent diabetic patients have to count on the administration of painful and discomforting insulin injections.

Core–shell hybrid nanocapsules for oral delivery of camptothecin: formulation development, in vitro and in vivo evaluation

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Hale Ünal ◽  
Ivana d’Angelo ◽  
Ester Pagano ◽  
Francesca Borrelli ◽  
Angelo Izzo ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Core Shell ◽  
Formulation Development ◽  
In Vivo Evaluation ◽  
Development In Vitro

Oral fast-dissolving films containing lutein nanocrystals for improved bioavailability: formulation development, in vitro and in vivo evaluation

2017 ◽  
Vol 18 (8) ◽  
pp. 2957-2964 ◽  
Author(s):  
Chen Liu ◽  
Daoxiao Chang ◽  
Xinhui Zhang ◽  
Hong Sui ◽  
Yindi Kong ◽  
...  
Keyword(s):  
Formulation Development ◽  
In Vivo Evaluation ◽  
Development In Vitro

scholarly journals 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties

1999 ◽  
Vol 277 (4) ◽  
pp. E617-E623 ◽  
Author(s):  
Christophe Broca ◽  
René Gross ◽  
Pierre Petit ◽  
Yves Sauvaire ◽  
Michèle Manteghetti ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Dependent Manner ◽  
Insulin Dependent ◽  
Glucose Tolerance Tests ◽  
Insulin Dependent Diabetic ◽  
Single Intravenous Administration

We have recently shown in vitro that 4-hydroxyisoleucine (4-OH-Ile), an amino acid extracted from fenugreek seeds, potentiates insulin secretion in a glucose-dependent manner. The present study was designed to investigate whether 4-OH-Ile could exert in vivo insulinotropic and antidiabetic properties. For this purpose, intravenous or oral glucose tolerance tests (IVGTTs and OGTTs, respectively) were performed not only in normal animals but also in a type II diabetes rat model. During IVGTT in normal rats or OGTT in normal dogs, 4-OH-Ile (18 mg/kg) improved glucose tolerance. The lactonic form of 4-OH-Ile was ineffective in normal rats. In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile (50 mg/kg) partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of 4-OH-Ile (50 mg/kg, daily) reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance. In vitro, 4-OH-Ile (200 μM) potentiated glucose (16.7 mM)-induced insulin release from NIDD rat-isolated islets. So, the antidiabetic effects of 4-OH-Ile on NIDD rats result, at least in part, from a direct pancreatic B cell stimulation.

scholarly journals Formulation development and in vitro and in vivo evaluation of membrane-moderated transdermal systems of ampicillin sodium in ethanol: pH 4.7 buffer solvent system

2007 ◽  
Vol 8 (1) ◽  
pp. E50-E55 ◽  
Author(s):  
Janardhanan Bagyalakshmi ◽  
Ramachandra Purapu Vamsikrishna ◽  
Rajappan Manavalan ◽  
Thengungal Kochupappy Ravi ◽  
Probal Kumar Manna
Keyword(s):  
Solvent System ◽  
Formulation Development ◽  
In Vivo Evaluation ◽  
Ampicillin Sodium

New resveratrol micelle formulation for ocular delivery: characterization and in vitro/in vivo evaluation

2020 ◽  
Vol 46 (12) ◽  
pp. 1960-1970
Author(s):  
Mengshuang Li ◽  
Ling Zhang ◽  
Rong Li ◽  
Meixing Yan
Keyword(s):  
Ocular Delivery ◽  
In Vivo Evaluation

Development, In Vitro and In Vivo Evaluation of Racecadotril Orodispersible Films for Pediatric Use

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Bing Wang ◽  
Liuliu Yang ◽  
Bing Wang ◽  
Chunlin Luo ◽  
Yuhan Wang ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Orodispersible Films ◽  
Development In Vitro ◽  
Pediatric Use
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