scholarly journals Sulfobetaine methacrylate-functionalized graphene oxide-IR780 nanohybrids aimed at improving breast cancer phototherapy

RSC Advances ◽  
2020 ◽  
Vol 10 (63) ◽  
pp. 38621-38630
Author(s):  
Miguel M. Leitão ◽  
Cátia G. Alves ◽  
Duarte de Melo-Diogo ◽  
Rita Lima-Sousa ◽  
André F. Moreira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Colloidal Stability ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Biologically Relevant

IR780 loaded SBMA-coated GO displayed an improved colloidal stability in biologically relevant media and an enhanced photothermal capacity.

Dual-functionalized graphene oxide for enhanced siRNA delivery to breast cancer cells

2016 ◽  
Vol 147 ◽  
pp. 315-325 ◽  
Author(s):  
Rana Imani ◽  
Wei Shao ◽  
Samira Taherkhani ◽  
Shahriar Hojjati Emami ◽  
Satya Prakash ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide

Sulfobetaine methacrylate-albumin-coated graphene oxide incorporating IR780 for enhanced breast cancer phototherapy

Nanomedicine ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. 453-464
Author(s):  
Bruna L Melo ◽  
Rita Lima-Sousa ◽  
Cátia G Alves ◽  
Paula Ferreira ◽  
André F Moreira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Bovine Serum Albumin ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Colloidal Stability ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Biologically Relevant

Aim: Enhance the colloidal stability and photothermal capacity of graphene oxide (GO) by functionalizing it with sulfobetaine methacrylate (SBMA)-grafted bovine serum albumin (BSA; i.e., SBMA- g-BSA) and by loading IR780, respectively. Materials & methods: SBMA- g-BSA coating and IR780 loading into GO was achieved through a simple sonication process. Results: SBMA- g-BSA-functionalized GO (SBMA-BSA/GO) presented an adequate size distribution and cytocompatibility. When in contact with biologically relevant media, the size of the SBMA-BSA/GO only increased by 8%. By loading IR780 into SBMA-BSA/GO, its photothermal capacity increased by twofold. The combination of near infrared light with SBMA-BSA/GO did not induce photocytotoxicity on breast cancer cells. In contrast, the interaction of IR780-loaded SBMA-BSA/GO with near infrared light caused the ablation of cancer cells. Conclusion: IR780-loaded SBMA-BSA/GO displayed an improved colloidal stability and phototherapeutic capacity.

Polymer Functionalized Graphene Oxide: A Versatile Nanoplatform for Drug/Gene Delivery

2015 ◽  
Vol 19 (18) ◽  
pp. 1828-1837 ◽  
Author(s):  
George V. Theodosopoulos ◽  
Panayiotis Bilalis ◽  
Georgios Sakellariou
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide
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