scholarly journals Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

RSC Advances ◽  
2020 ◽  
Vol 10 (67) ◽  
pp. 41202-41208
Author(s):  
Jung-Chang Kung ◽  
I-Ting Tseng ◽  
Chi-Sheng Chien ◽  
Sheng-Hui Lin ◽  
Chun-Chi Wang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carbon Dots ◽  
Negative Charge ◽  
Resistant Bacteria ◽  
Microwave Assisted Synthesis ◽  
Drug Resistant ◽  
Antibacterial Ability ◽  
Microwave Assisted ◽  
Drug Resistant Bacteria ◽  
One Step

In this research, negative-charge carbon dots (CDs) were synthesized in one-step using a microwave and found to have potential antibacterial ability against multi-drug resistant bacteria.

scholarly journals Novel Seleno- and Thio-Urea Containing Dihydropyrrol-2-One Analogues as Antibacterial Agents

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 321
Author(s):  
Shekh Sabir ◽  
Tsz Tin Yu ◽  
Rajesh Kuppusamy ◽  
Basmah Almohaywi ◽  
George Iskander ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibiotic Resistance ◽  
Quorum Sensing ◽  
Antibacterial Agents ◽  
Inhibitory Concentration ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Positive Bacterium ◽  
Quorum Sensing Inhibition ◽  
Drug Resistant Bacteria

The quorum sensing (QS) system in multi-drug-resistant bacteria such as P. aeruginosa is primarily responsible for the development of antibiotic resistance and is considered an attractive target for antimicrobial drug discovery. In this study, we synthesised a series of novel selenourea and thiourea-containing dihydropyrrol-2-one (DHP) analogues as LasR antagonists. The selenium DHP derivatives displayed significantly better quorum-sensing inhibition (QSI) activities than the corresponding sulphur analogues. The most potent analogue 3e efficiently inhibited the las QS system by 81% at 125 µM and 53% at 31 µM. Additionally, all the compounds were screened for their minimum inhibitory concentration (MIC) against the Gram-positive bacterium S. aureus, and interestingly, only the selenium analogues showed antibacterial activity, with 3c and 3e being the most potent with a MIC of 15.6 µM.

scholarly journals Synergistic Antibacterial Activity of Lantana camara L., Parthenium hysterophorus L., Cannabis sativa L. and Justicia adhatoda L. Leaves Extract against Procured Multi-drug Resistant Bacteria In Vitro

2021 ◽  
pp. 34-40
Author(s):  
Jyoti Chandola ◽  
Pooja Singh ◽  
Rishabh Garg ◽  
Narotam Sharma
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Cannabis Sativa ◽  
Lantana Camara ◽  
Parthenium Hysterophorus ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Weed Plants ◽  
Justicia Adhatoda

The scientific study of this research has been focused on synergistic antibacterial activity of two weed plants, Lantana camara L., Parthenium hysterophorus L. alongwith two medicinal plants, Cannabis sativa L., Justicia adhatoda L. against multi- drug resistant (MDR) bacteria. Dried leaf powders of the plants were extracted using air-dried method followed by the ethanol- solvent extraction method for the crude extract of the leaves. The crude extracts were tested for antibacterial activity against three MDR bacteria, that is, one Gram positive bacteria- Staphylococcus aureus and two Gram negative bacteria- Escherichia coli and Proteus mirabilis. Out of 18 antibiotics tested against procured bacteria, Staphylococcus aureus was resistant to 10 out of 10 tested antibiotics, Escherichia coli was resistant to 4 out of 12 tested antibiotics and Proteus mirabilis was resistant to 9 out of 10 tested antibiotics. The tested weed plants and the medicinal plants when combined together showed more zone of inhibition against multidrug resistant bacteria ( Two combinations of phytochemicals Lantana camara, Cannabis sativa and Lantana camara, Cannabis sativa, Justicia adhatoda, Parthenium hysterophorus showed maximum zones of inhibition, that is, 30 mm) as compared to when these plants were tested solitarily, showing pronounced antibacterial activity. These findings showed that the antibacterial activity enhanced when they were combined together and this potential could be used against various infectious diseases with more research and modification in this area. Weed plants also holds as much importance as the medicinal plants although not to that extent, but they clearly inhibit the growth of bacteria and this property of weeds along with the medicinal plants holds a promising future in treating many diseases caused by multi-drug resistant bacteria on the pharmaceutical level.

scholarly journals Quorum Sensing Inhibition in Chromobacterium violaceum, Antibacterial Activity and GC-MS Analysis of Centaurea praecox (Oliv. & Hiern) Extracts

2020 ◽  
Vol 9 (4) ◽  
pp. 1569-1577
Keyword(s):  
Antibacterial Activity ◽  
Quorum Sensing ◽  
Research Strategy ◽  
Chromobacterium Violaceum ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Control Drug ◽  
Ms Analysis ◽  
Drug Resistant Bacteria

The quorum sensing (QS) mechanism has become a viable research strategy for the discovery of plant-derived anti-virulent agents to control drug-resistant bacteria. The increasing incidences of drug-resistant bacteria and the effort to curb it necessitate this study. We investigated the QS inhibitory potential of Centaurea praecox extracts on Chromobacterium violaceum (CV), antibacterial activity, and determination of chemical composition using GC-MS. C. praecox was subjected to sequential extraction using hexane (HEX), dichloromethane (DCM), ethyl acetate (EA), ethanol (ET), and aqueous (AQ) solvents. The extracts were subsequently evaluated for antibacterial activity using disc diffusion and QS violacein inhibition using spectrophotometry. The antibacterial effects of the extracts were moderate on gram-positive bacteria at 4 mg/mL in the order: HEX >EA >DCM >ET =AQ. However, the DCM extract demonstrated the most effective violacein inhibition of ≥80% at 0.3 mg/mL. QS violacein inhibitions were generally found to be concentration-dependent in the order: DCM >EA >HEX >ET =AQ with efficacies of ≥ 90% inhibition at ≥ 0.6 mg/mL. GC-MS analysis on the most potent DCM extract revealed N-vinylmethanimine, N-ethyl formamide, and propanamide among components identified. We concluded that C. praecox DCM extract contains bioactive chemicals as QS inhibitors and potential anti-virulent agents capable of combating the pathogenicity of drug-resistant bacteria in vivo.

Vacancy‐Induced Antibacterial Activity of XS 2– y Quantum Dots against Drug‐Resistant Bacteria for Treatment of Bacterial Keratitis

Small ◽  
2020 ◽  
Vol 16 (42) ◽  
pp. 2004677
Author(s):  
Huiyuan Li ◽  
Xiao Wang ◽  
Xiaofei Zhao ◽  
Guanhua Li ◽  
Fengyan Pei ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Antibacterial Activity ◽  
Resistant Bacteria ◽  
Bacterial Keratitis ◽  
Drug Resistant ◽  
Drug Resistant Bacteria

scholarly journals Recombinant HNP-1 Produced by Escherichia coli Triggers Bacterial Apoptosis and Exhibits Antibacterial Activity against Drug-Resistant Bacteria

2022 ◽  
Author(s):  
Qi Xie ◽  
Yin Wang ◽  
Mengmeng Zhang ◽  
Shujia Wu ◽  
Wei Wei ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Mass Production ◽  
Recombinant Protein Expression ◽  
Cost Effective ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Effective Solution ◽  
Drug Resistant Bacteria ◽  
Human Neutrophil Peptide

Human neutrophil peptide-1 (HNP-1) is a promising antibiotic candidate, but its clinical application has been hampered by the difficulty of mass production and an inadequate understanding of its bactericidal mechanisms. In this study, we demonstrated that recombinant protein expression combined with ultrafiltration may be a simple and cost-effective solution to HNP-1 production.

scholarly journals Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rui Wang ◽  
Miusi Shi ◽  
Feiyan Xu ◽  
Yun Qiu ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Antibacterial Activities ◽  
Titanium Implants ◽  
Bone Tissue Regeneration ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Implant Infection ◽  
Tio2 Nanofibers ◽  
Antibacterial Ability ◽  
Drug Resistant Bacteria

Abstract Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.

scholarly journals Antibacterial activity of selected Dendrobium species against clinically isolated multiple drug resistant bacteria

2018 ◽  
Vol 12 (18) ◽  
pp. 426-432 ◽  
Author(s):  
Ram Paudel Mukti ◽  
Rajbanshi Neeta ◽  
Kumar Sah Anil ◽  
Acharya Sameer ◽  
Pant Bijaya
Keyword(s):  
Antibacterial Activity ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

scholarly journals Synergistic antibacterial effects of colistin in combination with aminoglycoside, carbapenems, cephalosporins, fluoroquinolones, tetracyclines, fosfomycin, and piperacillin on multidrug resistant Klebsiella pneumoniae isolates

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244673
Author(s):  
Julalak C. Ontong ◽  
Nwabor F. Ozioma ◽  
Supayang P. Voravuthikunchai ◽  
Sarunyou Chusri
Keyword(s):  
Antibacterial Activity ◽  
Klebsiella Pneumoniae ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Antibacterial Effects ◽  
Drug Resistant Bacteria ◽  
Multidrug Resistant Pathogens ◽  
Conventional Antibiotics ◽  
Global Health Problem

Multidrug resistant Enterobacterales have become a serious global health problem, with extended hospital stay and increased mortality. Antibiotic monotherapy has been reported ineffective against most drug resistant bacteria including Klebsiella pneumoniae, thus encouraging the use of multidrug therapies as an alternative antibacterial strategy. The present works assessed the antibacterial activity of colistin against K. pneumoniae isolates. Resistant isolates were tested against 16 conventional antibiotics alone and in combination with colistin. The results revealed that all colistin resistant isolates demonstrated multidrug resistance against the tested antibiotics except amikacin. At sub-inhibitory concentrations, combinations of colistin with amikacin, or fosfomycin showed synergism against 72.72% (8 of 11 isolates). Colistin with either of gentamicin, meropenem, cefoperazone, cefotaxime, ceftazidime, moxifloxacin, minocycline, or piperacillin exhibited synergism against 81.82% (9 of 11 isolates). Combinations of colistin with either of tobramycin or ciprofloxacin showed synergism against 45.45% (5 in 11 isolates), while combinations of colistin with imipenem or ceftolozane and tazobactam displayed 36.36% (4 of 11 isolates) and 63.64% (7 of 11 isolates) synergism. In addition, combinations of colistin with levofloxacin was synergistic against 90.91% (10 of 11 isolates). The results revealed that combinations of colistin with other antibiotics could effectively inhibit colistin resistant isolates of K. pneumoniae, and thus could be further explore for the treatment of multidrug resistant pathogens.

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