scholarly journals Use of nanohybrid nanomaterials in water treatment: highly efficient removal of ranitidine

RSC Advances ◽  
2020 ◽  
Vol 10 (61) ◽  
pp. 37050-37063
Author(s):  
Fahmi A. Abu Al-Rub ◽  
Mohammad M. Fares ◽  
Ahmad R. Mohammad
Keyword(s):  
Immune System ◽  
Water Treatment ◽  
Adverse Effects ◽  
Human Health ◽  
Pharmaceutical Drugs ◽  
Human Immune System ◽  
Efficient Removal ◽  
Highly Efficient ◽  
System P ◽  
Human Immune

Entire elimination of pharmaceutical drugs from waste- and domestic-waters has attracted great attention due to their potent adverse effects on human health, particularly the human immune system.

scholarly journals Importance of functional nutrition components on new Coronavirus disease (COVID-19) and other viral communicable diseases

2021 ◽  
Vol 7 (4) ◽  
pp. 286-299
Author(s):  
Serhan Mohammed ◽  
Nigün Özdemir ◽  
Ahmet Hilmi Çon
Keyword(s):  
Immune System ◽  
Human Health ◽  
Intestinal Microbiota ◽  
Viral Infections ◽  
Communicable Diseases ◽  
Bioactive Components ◽  
Human Immune System ◽  
Human Immune

There are no foods to prevent or treat the coronavirus alone; however, it has been proven that a healthy and balanced nutrition is crucial for health, particularly in times when the immune system might need to fight back. The present study provides insights about the properties of bioactive components of foods and herbs as a possible adjuvant support the human immune system against infections. Also, has focused on the interactions of the intestinal microbiota with human health in the treatment of Covid-19 and other viral infections. More research with strong recommendations is needed to better understand causality.

scholarly journals Surra: Trypanosomiasis in Livestock is Potential as Zoonotic Disease

2018 ◽  
Vol 28 (3) ◽  
pp. 139
Author(s):  
April Hari Wardhana ◽  
Dyah H Savitri
Keyword(s):  
Immune System ◽  
Human Serum ◽  
Human Health ◽  
Resistant Strain ◽  
Zoonotic Disease ◽  
Wide Distribution ◽  
Trypanosoma Evansi ◽  
Trypanosome Species ◽  
Human Immune System ◽  
Human Immune

<em>Trypanosoma evansi</em> is one of blood protozoans having the most wide distribution region compared to other Trypanosome species. The parasite causes trypanosomiasis known as Surra. The disease may cause mortality to the infected animals. In general <em>T evansi</em> only attack animal and cannot infect humans due to apolipoprotein 1 (Apo L-1) in human serum. The protein possess trypanolitic activity feature against <em>T. evansi</em> and effectively eliminates the protozoa. However, the knowledge of Surra infecting animals changed because there were atypical human trypanosomiasis cases reported in some countries due to <em>T. evansi</em>. The human Surra case occurred in Vietnam demonstrated that person with Apo L-1 could be infected by <em>T. evansi</em>. There was resistant strain of <em>T. evansi</em> found which able to disrupt human immune system. This paper will discuss Surra cases in both humans and animals, including mechanism of Apo L-1 on eliminating the parasite. Surra cases in human and animal should be seriously concerned because Surra could be pontential zoonosis threating human health.

scholarly journals INTERAKSI ANTARA MIKROBIOTA USUS DAN SISTEM KEKEBALAN TUBUH MANUSIA

2017 ◽  
Vol 17 (1) ◽  
pp. 35
Author(s):  
Fitri Elizabrth Br Hasibuan ◽  
Beivy Jonathan Kolondam
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Human Development ◽  
Human Health ◽  
Human Body ◽  
Human Microbiome ◽  
Human Immune System ◽  
Human Immune ◽  
Host Physiology

INTERAKSI ANTARA MIKROBIOTA USUS DAN SISTEM KEKEBALAN TUBUH MANUSIA Fitri Elizabrth Br Hasibuan dan Beivy Jonathan Kolondam ABSTRAK Sejumlah besar mikrobiota yang menghuni sistem pencernaan manusia memiliki peran penting dengan sistem kekebalan tubuh. Mikrobiota ini melaksanakan fungsi penting untuk fisiologi inang. Dalam tubuh manusia terdapat sekitar 10-100 triliun mikrobiota. Jumlah mikrobioma pada manusia paling banyak terdapat di usus, yaitu sekitar 100 triliun sel-sel mikrobiota yang terdiri dari 1.000 spesies berbeda. Mikrobiota adalah seluruh mikroba yang hidup di tubuh manusia yang terdiri dari bakteri, archae, virus, dan jamur yang pada umumnya hidup di setiap bagian tubuh manusia seperi kulit, vagina, hidung dan mulut. Bakteri pada mikrobioma manusia memiliki peran pada imunitas, nutrisi, dan perkembangan manusia. Di sini ditinjau tentang interaksi antara koloni mikroba dan sistem kekebalan tubuh dan implikasi dari temuan ini bagi kesehatan manusia. Kata-kata kunci: mikrobiota usus, sistem kekebalan tubuh, interaksi, bakteria.   INTERACTION BETWEEN GUT MICROBIOTA AND THE HUMAN IMMUNE SYSTEM ABSTRACT Most of the gut microbiota has important role in human immune system. These microbiota conducts important function for host physiology. The microbiota in the human body can range around 10 to 100 billion in number which contained 1,000 different species. Microbiota are the whole microbes living in human body such as bacteria, archaea, virus, and fungi, located on the skin or inside the vagina, nose and mouth. Bacteria in human microbiome has important roles in nutrition, immunity, and human development. This article discussed about interaction of microbes and immune system along with the implication of the interaction for human health. Keywords: Gut microbiota, immune system, interaction, bacteria

An ESIPT-based colorimetric and fluorescent probe with large Stokes shift for the sensitive detection of hypochlorous acid and its bioimaging in cells

2021 ◽  
Vol 45 (10) ◽  
pp. 4724-4728
Author(s):  
Haixian Ren ◽  
Fangjun Huo ◽  
Caixia Yin
Keyword(s):  
Immune System ◽  
Fluorescent Probe ◽  
Hypochlorous Acid ◽  
Stokes Shift ◽  
Vital Role ◽  
Human Immune System ◽  
Physiological Concentration ◽  
System P ◽  
Human Immune ◽  
Anti Inflammation

Hypochlorous acid (HOCl), with a low physiological concentration, plays a vital role in killing the pathogens and anti-inflammation in the human immune system.

721 AT1412, a patient-derived CD9 antibody in preclinical development promoting tumor immune infiltration and inducing tumor rejection

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A763-A763
Author(s):  
Remko Schotte ◽  
Julien Villaudy ◽  
Martijn Kedde ◽  
Wouter Pos ◽  
Daniel Go ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
T Cell ◽  
Tumor Cells ◽  
Tumor Rejection ◽  
Human Immune System ◽  
Preclinical Development ◽  
High Affinity ◽  
Human Immune ◽  
A375 Melanoma

BackgroundAdaptive immunity to cancer cells forms a crucial part of cancer immunotherapy. Recently, the importance of tumor B-cell signatures were shown to correlate with melanoma survival. We investigated whether tumor-targeting antibodies could be isolated from a patient that cured (now 13 years tumor-free) metastatic melanoma following adoptive transfer of ex vivo expanded autologous T cells.MethodsPatient‘s peripheral blood B cells were isolated and tested for the presence of tumor-reactive B cells using AIMM’s immmortalisation technology. Antibody AT1412 was identified by virtue of its differential binding to melanoma cells as compared to healthy melanocytes. AT1412 binds the tetraspanin CD9, a broadly expressed protein involved in multiple cellular activities in cancer and induces ADCC and ADCP by effector cells.ResultsSpontaneous immune rejection of tumors was observed in human immune system (HIS) mouse models implanted with CD9 genetically-disrupted A375 melanoma (A375-CD9KO) tumor cells, while A375wt cells were not cleared. Most notably, no tumor rejection of A375-CD9KO tumors was observed in NSG mice, indicating that blockade of CD9 makes tumor cells susceptible to immune rejection.CD9 has been described to regulate integrin signaling, e.g. LFA-1, VLA-4, VCAM-1 and ICAM-1. AT1412 was shown to modulate CD9 function by enhancing adhesion and transmigration of T cells to endothelial (HUVEC) cells. AT1412 was most potently enhancing transendothelial T-cell migration, in contrast to a high affinity version of AT1412 or other high affinity anti-CD9 reference antibodies (e.g. ALB6). Enhanced immune cell infiltration is also observed in immunodeficient mice harbouring a human immune system (HIS). AT1412 strongly enhanced CD8 T-cell and macrophage infiltration resulting in tumor rejection (A375 melanoma). PD-1 checkpoint blockade is further sustaining this effect. In a second melanoma model carrying a PD-1 resistant and highly aggressive tumor (SK-MEL5) AT1412 together with nivolumab was inducing full tumor rejection, while either one of the antibodies alone did not.ConclusionsThe safety of AT1412 has been assessed in preclinical development and is well tolerated up to 10 mg/kg (highest dose tested) by non human primates. AT1412 demonstrated a half-life of 8.5 days, supporting 2–3 weekly administration in humans. Besides transient thrombocytopenia no other pathological deviations were observed. No effect on coagulation parameters, bruising or bleeding were observed macro- or microscopically. The thrombocytopenia is reversible, and its recovery accelerated in those animals developing anti-drug antibodies. First in Human clinical study is planned to start early 2021.Ethics ApprovalStudy protocols were approved by the Medical Ethical Committee of the Leiden University Medical Center (Leiden, Netherlands).ConsentBlood was obtained after written informed consent by the patient.

scholarly journals Transplacental priming of the human immune system with environmental allergens can occur early in gestation

2000 ◽  
Vol 106 (3) ◽  
pp. 530-536 ◽  
Author(s):  
Zsolt Szépfalusi ◽  
Josefa Pichler ◽  
Stefan Elsässer ◽  
Katalin van Duren ◽  
Christof Ebner ◽  
...  
Keyword(s):  
Immune System ◽  
Human Immune System ◽  
Human Immune

scholarly journals Antimicrobial peptides: The ancient arm of the human immune system

Virulence ◽  
2010 ◽  
Vol 1 (5) ◽  
pp. 440-464 ◽  
Author(s):  
Jochen Wiesner ◽  
Andreas Vilcinskas
Keyword(s):  
Immune System ◽  
Antimicrobial Peptides ◽  
Human Immune System ◽  
Human Immune

On the use of multiple heterogeneous devices to speedup the execution of a computational model of the Human Immune System

2015 ◽  
Vol 267 ◽  
pp. 304-313 ◽  
Author(s):  
T.M. do Nascimento ◽  
J.M. de Oliveira ◽  
M.P. Xavier ◽  
A.B. Pigozzo ◽  
R.W. dos Santos ◽  
...  
Keyword(s):  
Immune System ◽  
Computational Model ◽  
Human Immune System ◽  
Heterogeneous Devices ◽  
Human Immune

Al-Muddaththir of the Quran Linked to the Covid-19 and Spanish Flu Pandemics: Circumstantial Evidence

2021 ◽  
Vol 02 (02) ◽  
Author(s):  
Baback Khodadoost ◽  
Keyword(s):  
Immune System ◽  
Circumstantial Evidence ◽  
The Moon ◽  
Human Immune System ◽  
Main Emphasis ◽  
Spanish Flu ◽  
Human Immune

Recently there have been speculations concerning a possible link between the covid-19 pandemic and al-Muddaththir, the 74th chapter of the Quran. An examination of this chapter presented in this article shows further evidences in support of these speculations. It is shown that indications of not only the current Covid-19 pandemic, but also the horrific 1918 Spanish flu can be detected in chapter 74. The main emphasis of this article will be to demonstrate the timings of the pandemic events as they appear to have been encoded in four of the chapter verses. The concept of Translational-Coding and in particular, its use in decoding one of the time-informing verses will be explained. A remarkable scheme of al-Muddaththir to announce the exact occurring years of the two major pandemics, will also be exposed. Coincidences of the Super Moon occurrences with major events of both, Covid-19 and Spanish flu pandemics, will be shown as the possible reason for “by the moon” swearing in verse 74:32. In connection with these observed coincidences, possible effect of the moon’s differential gravity on suppression of the human immune system during a Super Moon occurrence will be addressed. Some other verses in al-Muddaththir with possible relevance to the pandemic perspective of this chapter will also be discussed.

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