scholarly journals Nanocarriers for ocular drug delivery: current status and translational opportunity

RSC Advances ◽  
2020 ◽  
Vol 10 (46) ◽  
pp. 27835-27855 ◽  
Author(s):  
Srividya Gorantla ◽  
Vamshi Krishna Rapalli ◽  
Tejashree Waghule ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Current Status ◽  
Ocular Diseases

Ocular diseases have a significant effect on vision and quality of life.

scholarly journals Women in surgery: a systematic review of 25 years

BMJ Leader ◽  
2020 ◽  
pp. leader-2019-000199
Author(s):  
Charleen Singh ◽  
Caitlin Loseth ◽  
Noordeen Shoqirat
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Work Life ◽  
Current Status ◽  
Leadership Roles ◽  
Review Of The Literature ◽  
Life Balance ◽  
Surgical Residency ◽  
Meta Analyses

The number of women entering medicine significantly increased over the last decades. Currently, over half of the medical students are women but less than half are applying to surgery and even less go on to surgical specialties. Even fewer women are seen in leadership roles throughout the profession of surgery and surgical residency. Our purpose of the literature review is to identify any themes, which would provide insight to the current phenomenon. We used the Preferred Reporting Items for Systemic Reviews and Meta-Analyses method for a systematic review of the literature over a 20-year period (1998–2018). Five broad themes were identified: education and recruitment, career development, impact of/on life around the globe and surgical subspecialties as areas of barriers for women entering or considering surgery. The systematic review suggests there are opportunities to improve and encourage women entering the profession of surgery as well as the quality of life for surgeons. Creating systems for mentorship across programmes, having policies to support work–life balance and recognising surgical training overlaps with childbearing years are key opportunities for improvement. Improving the current status in surgery will require direction from leadership.

scholarly journals The Current Status of Integrative Oncology in Korea

2021 ◽  
Vol 20 ◽  
pp. 153473542110638
Author(s):  
Eun-Bin Kwag ◽  
Soo-Dam Kim ◽  
Ji Hye Park ◽  
So-Jung Park ◽  
Mi-Kyung Jeong ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Causes Of Death ◽  
Survival Rates ◽  
Current Status ◽  
Integrative Oncology ◽  
Recurrence Rates ◽  
Current State ◽  
Look Ahead

Cancer is one of the leading causes of death worldwide, and Korea is no exception. Humanity has been fighting cancer for many years, and as a result, we now have effective treatments such as chemotherapy, radiation, and surgery. However, there are other issues that we are only now beginning to address, such as cancer patients’ quality of life. Moreover, numerous studies show that addressing these issues holistically is critical for overall cancer treatment and survival rates. This paper describes how Korea is attempting to reduce cancer incidence and recurrence rates while also managing the quality of life of cancer patients. Integrative Oncology is the field that addresses these broad issues, and understanding the current state of integrative oncology in Korea is critical. The goal of this paper is to provide an overview of the current state of integrative oncology in Korea as well as to look ahead to future developments.

Poster 320: Improving Quality of Life with Intrathecal Targeted Drug Delivery: A Case Report

PM&R ◽  
2018 ◽  
Vol 10 ◽  
pp. S106-S106
Author(s):  
Marissa L. Dombovy-Johnson ◽  
William H. Fredericks ◽  
Thomas P. Pittelkow
Keyword(s):  
Quality Of Life ◽  
Drug Delivery ◽  
Case Report ◽  
Targeted Drug Delivery ◽  
Targeted Drug

Quality of life indicators and health: Current status and emerging conceptions

1996 ◽  
Vol 39 (1) ◽  
pp. 65-88 ◽  
Author(s):  
Dennis Raphael ◽  
Rebecca Renwick ◽  
Ivan Brown ◽  
Irving Rootman
Keyword(s):  
Quality Of Life ◽  
Current Status ◽  
Quality Of Life Indicators

The Current Status of Combined Radiotherapy and Chemotherapy for Locally Advanced or Resected Pancreas Cancer

2005 ◽  
Vol 3 (5) ◽  
pp. 637-642 ◽  
Author(s):  
Mary F. Mulcahy ◽  
Andrew O. Wahl ◽  
William Small
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Surgical Resection ◽  
Primary Tumor ◽  
Pancreas Cancer ◽  
Locally Advanced ◽  
Clinical Situation ◽  
Current Status ◽  
Therapy Goals

Pancreas cancer is the fourth most common cause of cancer deaths. Even for the small percentage of patients who can undergo surgical resection of the primary tumor, the risk of recurrence remains unacceptably high. For patients with localized disease that is not amenable to surgical resection, pain related to the primary tumor can significantly impair quality of life. Attempts to improve the duration and quality of life for these patients have included both chemotherapy and radiotherapy. The addition of chemotherapy to radiation may enhance the local effects of radiation or provide treatment of disease outside the radiation field. The results of clinical trials evaluating the appropriate therapy for locally advanced or resected disease have been inconsistent. In some instances, the methods used in these studies became outdated before the results were available. Hopefully, advances in radiation techniques and systemic drug therapy will provide more durable and clinically relevant results. Meanwhile, treatment decisions should be tailored to the clinical situation, including consideration of treatment toxicity and therapy goals. Recognizing which patients are likely to benefit from combination therapy or systemic therapy alone is a subject of future and ongoing clinical trials.

A Refresher on Herpes Zoster, Current Status on Vaccination, and the Role of the Dermatologist

2011 ◽  
Vol 15 (4) ◽  
pp. 185-191 ◽  
Author(s):  
Lyn C. Guenther ◽  
Charles W. Lynde
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
Herpes Zoster ◽  
Preventive Medicine ◽  
Primary Care Physicians ◽  
Current Status ◽  
Age Group ◽  
Increased Risk

Background: Herpes zoster (HZ) and postherpetic neuralgia (PHN) have a significant impact on quality of life. PHN is often chronic and difficult to treat. Dermatologists have always been involved in making the diagnosis of these conditions and, most recently, teaching the need for early antiviral therapy. Objective: With the introduction of a new vaccine, HZ and its difficult-to-treat complication PHN can be prevented or minimized. Preventive medicine is important and has been supported by dermatologists with sun safety programs. Patients receiving biologics are at increased risk of developing zoster. Conclusion: Dermatologists should embrace zoster vaccination and recommend routine vaccination of immunocompetent individuals > age 60 years, as well as patients of any age who are starting immunosuppressants, including biologics. Given that individuals over age 50 years are at risk for PHN and studies have shown that the vaccine's immunogenicity and safety are maintained in individuals age 50 to 59 years, vaccination in this age group may be considered. Some dermatologists may consider vaccinating their own patients, but most will likely recommend that vaccination be performed by their patients' primary care physicians.

scholarly journals The Analysis of Fertility Quality of Life and the Influencing Factors of Patients with Repeated Implantation Failure

2020 ◽  
Author(s):  
Ying Ni ◽  
Chenye Tong ◽  
Limin Huang ◽  
Wenjie Zhou ◽  
Aijun Zhang
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Influencing Factors ◽  
Psychological Status ◽  
Current Status ◽  
Implantation Failure ◽  
Repeated Implantation Failure ◽  
Infertile Women ◽  
Self Rating

Abstract Background: The objective of this study was to investigate the current status of fertility quality of life (QoL) and explore the influencing factors for infertile women with repeated implantation failure (RIF).Methods: The sample consisted of 137 infertile women with RIF who were under treatment from January 2019 to December 2019 in the Reproductive Medical Center of Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine in China. A general information questionnaire, FertiQoL scale, perceived social support scale (PSSS), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were used to analyse the fertility QoL and related factors of RIF patients.Results: The total fertility QoL score of RIF patients was 60.44 ± 11.60. The results of multivariate regression analysis showed that residence, financial difficulties, male infertility, BMI index, depression, and family social support were the main factors that influenced the fertility QoL of RIF patients (adjusted R2 = 0.762).Conclusion: Based on the results of this study, RIF patients’ psychological status must be addressed. Corresponding interventions such as building a sound family and social support system, creating a good medical environment and offering diverse health education should be provided to improve the fertility QoL of RIF patients.

scholarly journals Actividad Física y sedentarismo: Repercusiones sobre la salud y calidad de vida de las personas mayores (Physical activity and sedentary lifestyle: Impact on health and quality of life of older people)

Retos ◽  
2015 ◽  
pp. 126-129
Author(s):  
Francisco Salinas Martínez ◽  
Armando Cocca ◽  
Kamal Mohamed ◽  
Jesús Viciana Ramírez
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older People ◽  
Sedentary Lifestyle ◽  
The Elderly ◽  
Current Status ◽  
Negative Effects ◽  
Calidad De Vida ◽  
Elderly Health

Realizamos un análisis del estado actual de las personas mayores en relación con la actividad física y el sedentarismo, éste último aspecto convertido en la actualidad como una de las principales fuentes de amenaza para la salud pública de los países europeos y americanos. Damos a conocer los efectos negativos de la inactividad física sobre los parámetros cardiovasculares, diabetes, depresión y cáncer, entre otros. Mostramos los beneficios de la actividad física (herramienta clave para solucionar los problemas propios del sedentarismo) para la salud de este colectivo de la población; al tiempo que estudiamos las razones por las que las personas mayores acuden a los programas de actividad física. Finalmente, aportamos una serie de conclusiones.Palabras clave: Actividad Física. Calidad de Vida. Personas mayores. Salud. Sedentarismo.Abstract: We analyzed the current status of the elderly in relation to physical activity and sedentary, the latter now become a major source of threat to public health in the European and American countries. We report the negative effects of physical inactivity on cardiovascular parameters, diabetes, depression and cancer, among others. We show the benefits of physical activity (a key tool to solve the problems of the sedentary lifestyle) for the health of this group of the population while we study the reasons why older people attend physical activity programs. Finally, we provide a number of conclusions. Keywords: Physical Activity. Quality of Life. Elderly. Health. Sedentary.

scholarly journals FACTOR ANALYSIS AS OPTIMAL METHOD IN DETERMINING MOTORIC ABILITIES AND THE QUALITY OF LIFE, HEALTH AND SOCIAL WELLNESS OF PERSPECTIVE JUDOKAS

2018 ◽  
Vol 16 (1) ◽  
pp. 107
Author(s):  
Dragan Popović ◽  
Dragana Mitić ◽  
Jasna Popović ◽  
Evagelija Boli ◽  
Evdokia Samouilidou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Education ◽  
Life Assessment ◽  
Current Status ◽  
Optimal Method ◽  
Scale Scores ◽  
And Gender ◽  
Individual Scale ◽  
The Individual

The goal of this study is a comparative analysis of the possibilities of physical education for children with health problems and the current status in boys and girls. Understanding the concept of impaired health is a precondition for the realization of the training process and possible integration in the process of physical education, according to the structure of health disadvantages. Quality of life assessment is performed on three levels. The first level are items that are given in the form of a statement. On the second level, item-like particles are observed in the sub-segments (scales that cover different dimensions of health and quality of life). The raw scores of each scale are transformed into standardized ones with a possible value of 1-4, which facilitates the interpretation of the results. The third level represents total physical and psycho-social health. Up to this level, there are certain mathematical procedures, based on the individual scale scores. Comparative analyses in regard of the cultural and gender specificities are provided, based on MANOVA and DISCRA analyses, within the introductory part, and 11 scales of the Questionnaire. Analysis of the data point out major differences in the possibility of physical activity application in children with medical conditions, with a special overview of boys and girls from diverse cultural and social backgrounds, in Serbia and the Northern Aegean region of Greece.

scholarly journals Pancreatic Cancer Related Pain: Review of Pathophysiology and Intrathecal Drug Delivery Systems for Pain Management

2021 ◽  
pp. E583-E594
Keyword(s):  
Quality Of Life ◽  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Pain Management ◽  
Cancer Pain ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Narrative Review ◽  
Intrathecal Drug Delivery

BACKGROUND: Pancreatic cancer (PC) is one of the most lethal cancers and is the eleventh most common cancer worldwide. This disease is characterized by an often-fatal evolution and a high burden of symptoms, particularly pain. Several studies have demonstrated that pancreatic cancer patients have a high prevalence of pain, with up to 82% of patients reporting pain, often requiring systemic strong opioids as mainstay treatment. This comprehensive review of pancreatic cancer related pain (PCRP), focuses on current mechanisms that lead to pain including regional invasion processes, as well as the local secretion of factors that sensitize nociceptive nerves. OBJECTIVE: Our objective was to conduct a review of PCRP and provide updates on intrathecal drug delivery in PC therapeutic recommendations. STUDY DESIGN: We used a narrative review design. We present a novel perspective in the field of pain research by converging data from intrathecal drug delivery trials with previous elements of molecular pain research in PCRP. METHODS: The literature review relating to PCRP pathophysiology and intrathecal drug delivery systems (IDDS) was done with searches of English, French, and Spanish abstracts, using PubMed, Dynamed, EMBASE, SciELO, Uptodate, Google Scholar, and manual searches of the bibliographies of known primary and review articles from IDDS inception until August 2020. Different search strings based on MESH terms were used including: pain, chronic pain, cancer pain, prevalence, pathophysiology, pancreatic cancer, analgesia, invasive pain procedures, celiac plexus neurolysis, pancreatic neuropathy, intrathecal drug delivery, or a combination of these terms. A narrative review based on these sources was prepared. RESULTS: This paper reviews aspects related to pancreatic adenocarcinoma and PCRP prevalence and focuses on recent developments in pathophysiology with IDDS as a pain management strategy. We summarize the best available evidence regarding intrathecal therapy (IT) for PCRP management; 18 studies of IDDS including at least 236 PC patients are analyzed. LIMITATIONS: Some limitations include: IDDS studies heterogeneity regarding disease stage, patient population, and technical aspects, such as catheter placement and treatment regimen, do not allow integration of studies. CONCLUSION: This review analyzes both past and current literature with a critical analysis of findings and respective recommendations. Most studies of IDDS in PCRP evaluate outcomes on pain using one-dimensional pain scales, such as VAS. Other relevant results, such as performance status or quality of life, are not frequently reported. Burden of disease variables, such as cancer stage, location, and comorbidities, like depression and systemic analgesia co-prescription, are usually not presented in these studies. In the same way, most studies do not precisely inform IDDS titration and IT medication. These factors make integration of IDDS in PC studies difficult. Future studies regarding impact of IDDS on pain control on quality of life, in this particular population, may help clinicians in deciding the optimal time and approach for IDDS. The studies should report data on particular disease, comorbidities, and treatment regimens. KEY WORDS: Adenocarcinoma, cancer pain, pain, pancreatic carcinoma, pancreatic neoplasms, pain management, physiopathology, prevalence

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