scholarly journals Intervention effects of lotus leaf flavonoids on gastric mucosal lesions in mice infected with Helicobacter pylori

RSC Advances ◽  
2020 ◽  
Vol 10 (40) ◽  
pp. 23510-23521 ◽  
Author(s):  
Ruokun Yi ◽  
Feng-Bo Wang ◽  
Fang Tan ◽  
Xingyao Long ◽  
Yanni Pan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Intervention Effects ◽  
Gastric Mucosal Lesions ◽  
Lotus Leaf ◽  
Mucosal Lesions

Lotus leaf flavonoids can inhibit gastric mucosal lesions caused by Helicobacter pylori in mice.

Early gastric mucosal lesions in helicobacter pylori infected mongolian gerbils

2001 ◽  
Vol 33 ◽  
pp. A84
Author(s):  
Francesco Franceschi ◽  
Antonia R. Sepulveda ◽  
Kevin Otten ◽  
Antonio Gasbarrini ◽  
Paolo Pola ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mongolian Gerbils ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Acute gastric mucosal lesions caused by Helicobacter pylori initial infection

2007 ◽  
Vol 49 (2) ◽  
pp. 253-255 ◽  
Author(s):  
TAKEHISA FUJIWAKI ◽  
MANABU KUROKAWA ◽  
DAISUKE CHINUKI ◽  
CHIHIRO ISHIOKA
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosal Lesions ◽  
Initial Infection ◽  
Mucosal Lesions

Acute gastric mucosal lesions (AGML) caused by Helicobacter, pylori (H. pylori) infection after endoscopy

1998 ◽  
Vol 114 ◽  
pp. A149 ◽  
Author(s):  
N. Hirahara ◽  
T. Moriai ◽  
S. Okamoto ◽  
Y. Morita ◽  
T. Sato ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions ◽  
H Pylori

Acute gastric mucosal lesions caused by acute infection of non‐ Helicobacter pylori Helicobacter : a case report

Helicobacter ◽  
2021 ◽  
Author(s):  
Toshihisa Tsukadaira ◽  
Seiichi Hayashi ◽  
Hiroyoshi Ota ◽  
Natsuko Kobayashi ◽  
Yasuhiro Sekiguchi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Case Report ◽  
Acute Infection ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Resistance of mast cell-deficient W/Wv mice to H.pylori -associated gastric mucosal lesions

2001 ◽  
Vol 120 (5) ◽  
pp. A650-A650
Author(s):  
H SUZUKI ◽  
M MIYAZAWA ◽  
A KAI ◽  
S MIURA ◽  
H NAGATA ◽  
...  
Keyword(s):  
Mast Cell ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective Effect of Pyrus ussuriensis Maxim. Extract against Ethanol-Induced Gastritis in Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 439
Author(s):  
Naila Boby ◽  
Muhammad Aleem Abbas ◽  
Eon-Bee Lee ◽  
Zi-Eum Im ◽  
Walter H. Hsu ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Adenosine Monophosphate ◽  
Ethanol Ingestion ◽  
Dependent Manner ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Cellular Degeneration ◽  
Mucosal Lesions ◽  
Pyrus Ussuriensis Maxim

Pyrus ussuriensis Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine for asthma, cough, and atopic dermatitis in Korea and China. Although it was originally shown to possess anti-inflammatory, antioxidant, and antiatopic properties, its gastroprotective effects have not been investigated. In the present study, we evaluated the protective effects of Pyrus ussuriensis Maxim extract (PUE) against ethanol-induced gastritis in rats. The bioactive compound profile of PUE was determined by gas chromatography mass spectroscopy (GC-MS) and high-performance liquid chromatography (HPLC). The gastroprotection of PUE at different doses (250 and 500 mg/kg body weight) prior to ethanol ingestion was evaluated using an in vivo gastritis rat model. Several endpoints were evaluated, including gastric mucosal lesions, cellular degeneration, intracellular damage, and immunohistochemical localization of leucocyte common antigen. The gastric mucosal injury and ulcer score were determined by evaluating the inflamed gastric mucosa and by histological examination. To identify the mechanisms of gastroprotection by PUE, antisecretory action and plasma prostaglandin E2 (PGE2), gastric mucosal cyclic adenosine monophosphate (cAMP), and histamine levels were measured. PUE exhibited significant antioxidant effects with IC50 values of 56.18 and 22.49 µg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′- azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) inhibition (%), respectively. In addition, GC/MS and HPLC analyses revealed several bioactive compounds of PUE. Pretreatment with PUE significantly (P < 0.05) decreased the ulcer index by preventing gastric mucosal lesions, erosion, and cellular degeneration. An immunohistochemical analysis revealed that PUE markedly attenuated leucocyte infiltration in a dose-dependent manner. The enhancement of PGE2 levels and attenuation of cAMP levels along with the inhibition of histamine release following PUE pretreatment was associated with the cytoprotective and healing effects of PUE. In contrast, the downregulation of the H+/K+ ATPase pathway as well as muscarinic receptor (M3R) and histamine receptor (H2R) inhibition was also involved in the gastroprotective effects of PUE; however, the expression of cholecystokinin-2 receptors (CCK2R) was unchanged. Finally, no signs of toxicity were observed following PUE treatment. Based on our results, we conclude that PUE represents an effective therapeutic option to reduce the risk of gastritis and warrants further study.

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