scholarly journals High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14161-14169 ◽  
Author(s):  
Yanrong Zhou ◽  
Xiaohan Jiang ◽  
Ting Tong ◽  
Liurong Fang ◽  
Yuan Wu ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
High Antiviral Activity

Mercaptoethane sulfonate functionalised Te/BSA nanostars are prepared and exhibit excellent antiviral activity against arteriviruses and coronaviruses.

scholarly journals In vitro activity of human recombinant alpha-2b interferon against SARS-CoV-2 virus

2021 ◽  
Vol 66 (2) ◽  
pp. 123-128
Author(s):  
S. Ya. Loginova ◽  
V. N. Shсhukina ◽  
S. V. Savenko ◽  
S. V. Borisevich
Keyword(s):  
Cell Culture ◽  
Antiviral Activity ◽  
Viral Infections ◽  
Complete Suppression ◽  
Antiviral Efficacy ◽  
Prevention And Treatment ◽  
Proven Efficacy ◽  
High Antiviral Activity

Introduction. The pandemic spread of a new coronavirus infection, COVID-19, has caused a global emergency and attracted the attention of public health professionals and the population of all countries. A significant increase in the number of new cases of SARS-CoV-2 infection demonstrates the urgency of finding drugs effective against this pathogen.The aim of this work was to evaluate the in vitro antiviral efficacy of human recombinant alpha-2b interferon (IFN-α2b) against SARS-CoV-2 virus.Material and methods. The experiments had been carried out on Vero Cl008, the continuous line of African green monkey (Chlorocebus sabaeus) kidney cells. The effectiveness of the drugs was assessed by the suppression of viral reproduction in vitro. The biological activity was determined using titration of a virus-containing suspension in a Vero Cl008 cell culture by the formation of negative colonies.Results. The antiviral efficacy of the IFN-α2b-based medications, which have a high safety profile and proven efficacy in the prevention and treatment of influenza and acute respiratory viral infections (ARVI), has been studied against the new pandemic SARS-CoV-2 virus in vitro experiments in Vero C1008 cell culture. IFN-α2b effectively inhibits the reproduction of the virus when applied both 24 hrs before and 2 hrs after infection. In the IFN-α2b concentration range 102–106 IU/ml a complete suppression of the reproduction of the SARS-CoV-2 virus had been demonstrated.Discussion. IFN-α2b demonstrated in vitro high antiviral activity against SARS-CoV-2. In addition, the substance has a high chemotherapeutic index (>1000).Conclusion. Medications for intranasal use based on IFN-α2b have high antiviral activity and are promising drugs for in vivo study in terms of prevention and treatment of COVID-19.

Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives

2008 ◽  
Vol 63 (9-10) ◽  
pp. 667-674 ◽  
Author(s):  
Farag A. El-Essawy ◽  
Wael A. El-Sayed ◽  
Sherif A. El-Kafrawy ◽  
Asmaa S. Morshedy ◽  
Adel-H. Abdel-Rahman
Keyword(s):  
Sulfuric Acid ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Alkylating Agents ◽  
Acid Hydrazide ◽  
Virus Activity ◽  
B Virus ◽  
Thiadiazole Derivative ◽  
High Antiviral Activity

A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity

scholarly journals Antiviral Carbon Dots: Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms (Small 13/2020)

Small ◽  
2020 ◽  
Vol 16 (13) ◽  
pp. 2070068 ◽  
Author(s):  
Ting Tong ◽  
Hongwei Hu ◽  
Junwei Zhou ◽  
Shuangfei Deng ◽  
Xiaotong Zhang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbon Dots ◽  
Glycyrrhizic Acid ◽  
High Antiviral Activity

scholarly journals A Critical Subset Model Provides a Conceptual Basis for the High Antiviral Activity of Major HIV Drugs

2011 ◽  
Vol 3 (91) ◽  
pp. 91ra63-91ra63 ◽  
Author(s):  
L. Shen ◽  
S. A. Rabi ◽  
A. R. Sedaghat ◽  
L. Shan ◽  
J. Lai ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Conceptual Basis ◽  
Hiv Drugs ◽  
High Antiviral Activity

scholarly journals Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Small ◽  
2020 ◽  
Vol 16 (13) ◽  
pp. 1906206 ◽  
Author(s):  
Ting Tong ◽  
Hongwei Hu ◽  
Junwei Zhou ◽  
Shuangfei Deng ◽  
Xiaotong Zhang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbon Dots ◽  
Glycyrrhizic Acid ◽  
High Antiviral Activity

scholarly journals High antiviral activity of NS 5A inhibitor ABT ‐530 with paritaprevir/ritonavir and ribavirin against hepatitis C virus genotype 3 infection

2016 ◽  
Vol 36 (8) ◽  
pp. 1125-1132 ◽  
Author(s):  
Fred Poordad ◽  
Charles S. Landis ◽  
Armen Asatryan ◽  
Daniel F. Jackson ◽  
Teresa I. Ng ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Genotype 3 ◽  
Virus Genotype ◽  
High Antiviral Activity

scholarly journals A Cell-penetrating Antibody Fragment against HIV-1 Rev Has High Antiviral Activity

2014 ◽  
Vol 289 (29) ◽  
pp. 20222-20233 ◽  
Author(s):  
Xiaolei Zhuang ◽  
Stephen J. Stahl ◽  
Norman R. Watts ◽  
Michael A. DiMattia ◽  
Alasdair C. Steven ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Antibody Fragment ◽  
Cell Penetrating ◽  
A Cell ◽  
Hiv 1 ◽  
High Antiviral Activity

scholarly journals Rapid Construction of Adeno-Associated Virus Vectors Expressing Multiple Short Hairpin RNAs with High Antiviral Activity Against Echovirus 30

2010 ◽  
Vol 20 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Diana Rothe ◽  
Gisela Wajant ◽  
Hans-Peter Grunert ◽  
Heinz Zeichhardt ◽  
Henry Fechner ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Adeno Associated Virus ◽  
Virus Vectors ◽  
Echovirus 30 ◽  
Rapid Construction ◽  
Short Hairpin ◽  
Short Hairpin Rnas ◽  
High Antiviral Activity

O115 : High antiviral activity of the HBV core inhibitor NVR 3-778 in the humanized uPA/SCID mouse model

2015 ◽  
Vol 62 ◽  
pp. S250 ◽  
Author(s):  
K. Klumpp ◽  
T. Shimada ◽  
L Allweiss ◽  
T. Volz ◽  
M. Luetgehetman ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Mouse Model ◽  
Scid Mouse ◽  
Scid Mouse Model ◽  
High Antiviral Activity

Anti-HIV Activity of New Substituted 1,3,4-Oxadiazole Derivatives and their Acyclic Nucleoside Analogues

2009 ◽  
Vol 64 (11-12) ◽  
pp. 773-778 ◽  
Author(s):  
Wael A. El-Sayed ◽  
Farag A. El-Essawy ◽  
Omar M. Ali ◽  
Barsis S. Nasr ◽  
Mohamed M. Abdalla ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Sugar Hydrazones ◽  
Acyclic Nucleoside Analogues ◽  
Ciency Virus ◽  
Human Immunodefi Ciency Virus ◽  
Oxadiazole Derivatives ◽  
Acyclic Nucleoside ◽  
Anti Hiv ◽  
Hiv 1 ◽  
High Antiviral Activity

A number of new 5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazole derivatives, 2 - 5 and 8 - 11, were synthesized. The 2-{5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio}acetohydrazones 6a and 6b were synthesized by the reaction of the hydrazide 4 with the corresponding monosaccharides. Cyclization of the sugar hydrazones 6a and 6b with acetic anhydride afforded the substituted oxadiazoline derivatives 7a and 7b. The synthesized compounds were evaluated for their antiviral activity against, the human immunodefi ciency virus (HIV-1) and some of these compounds showed moderate to high antiviral activity.

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