scholarly journals Reasons for enhanced activity of doxorubicin on co-delivery with octa(3-aminopropyl)silsesquioxane

RSC Advances ◽  
2020 ◽  
Vol 10 (26) ◽  
pp. 15579-15585 ◽  
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Irena Bak-Sypien ◽  
Marek Cypryk ◽  
Urszula Steinke ◽  
...  
Keyword(s):  
Functional Groups ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Enhanced Activity ◽  
Oligomeric Silsesquioxane

The interaction between polyhedral oligomeric silsesquioxane (POSS) and doxorubicin, leading to formation of active complexes involving POSS functional aminopropyl groups and anthracycline functional groups.

scholarly journals Evaluation of Polyhedral Oligomeric Silsesquioxane Porphyrin Derivatives on Photodynamic Therapy

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4965
Author(s):  
Paolo Siano ◽  
Alexis Johnston ◽  
Paula Loman-Cortes ◽  
Zaneta Zhin ◽  
Juan L. Vivero-Escoto
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Functional Groups ◽  
Steric Hindrance ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Porphyrin Derivatives ◽  
And Performance ◽  
Oligomeric Silsesquioxane

Polyhedral oligomeric silsesquioxane (POSS) is a promising scaffold to be used as delivery system. POSS can modify the properties of photosensitizers to enhance their efficacy toward photodynamic therapy (PDT). In this work, we designed, synthesized and characterized five different POSS porphyrin (POSSPs 1–5) derivatives containing hydrophobic (1–3) and hydrophilic (4 and 5) functional groups. In general, all the POSSPs showed a better singlet oxygen quantum yield than the parent porphyrins due to the steric hindrance from the POSS unique structure. POSSPs 1 and 3 containing isobutyl groups showed better PDT performance in cancer cells at lower concentrations than POSSPs 4 and 5. However; at higher concentrations, the POSSP4 containing hydrophilic groups has an enhanced PDT efficiency as compared with the parent porphyrin. We envision that the chemical tunability of POSSs can be used as a promising option to improve the delivery and performance of photosensitizers.

scholarly journals Fluoroalkyl POSS with Dual Functional Groups as a Molecular Filler for Lowering Refractive Indices and Improving Thermomechanical Properties of PMMA

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1332 ◽  
Author(s):  
Kazunari Ueda ◽  
Kazuo Tanaka ◽  
Yoshiki Chujo
Keyword(s):  
Refractive Index ◽  
Methyl Methacrylate ◽  
Functional Groups ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Thermomechanical Properties ◽  
Optical Measurements ◽  
Refractive Indices ◽  
Casting Method ◽  
Dual Functional ◽  
Oligomeric Silsesquioxane

The dual-functionalized polyhedral oligomeric silsesquioxane (POSS) derivatives, which have the seven fluorinated alkanes and the single acrylate ester on the silica cube, were designed as a filler for lowering the refractive index (RI) and improving thermomechanical properties in poly(methyl methacrylate) (PMMA). The desired dual-functionalized POSS fillers were prepared, and because of its high miscibility, homogeneous films were readily obtained, by the casting method, with the mixture solutions containing the modified POSS and the polymers. From optical measurements, it was found that the larger effects of lowering the RIs of the PMMA matrices were observed from the modified POSS than those of the octa-substituted POSS derivatives with the homogeneous substituents. It should be mentioned that the degradation temperatures and the storage moduli were able to be greatly elevated by loading the present POSS fillers. Finally, it was demonstrated that the methacrylate ester-tethered POSS should be the most effective filler for modulating PMMA (Δn = −0.020, ΔTd20 = +53 °C, ΔE'/E' = +72%).

Functional groups on POSS nanoparticles influence the self-assembled structures of diblock copolymer composites

RSC Advances ◽  
2014 ◽  
Vol 4 (66) ◽  
pp. 34849-34859 ◽  
Author(s):  
Yi-Syuan Lu ◽  
Shiao-Wei Kuo
Keyword(s):  
Functional Groups ◽  
Diblock Copolymer ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
The Self ◽  
Self Assembled ◽  
Oligomeric Silsesquioxane ◽  
Copolymer Composites

The influence of the functional groups presented by polyhedral oligomeric silsesquioxane (POSS) nanoparticles (NPs) on the self-assembled structures formed by diblock copolymer composites were detail discussed.

Simplistic one-pot synthesis of an inorganic–organic cubic caged material: a new interface for detecting toxic bisphenol-A electrochemically

2020 ◽  
Vol 44 (46) ◽  
pp. 20192-20202
Author(s):  
Dhurkasini Ananthakrishnan ◽  
Harikrishnan Venkatesvaran ◽  
Aarthi Kannan ◽  
Sakthivel Gandhi
Keyword(s):  
Bisphenol A ◽  
Functional Groups ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Electrochemical Sensing ◽  
Hybrid Nanomaterials ◽  
One Pot ◽  
One Pot Synthesis ◽  
Oligomeric Silsesquioxane

Polyhedral oligomeric silsesquioxane (POSS) based hybrid nanomaterials have been terminally functionalised with three different functional groups and are newly explored for the electrochemical sensing of bisphenol A.

Model Polyhedral Oligomeric Silsesquioxane Thin Films for Coating Applications

2002 ◽  
Author(s):  
Brent Viers ◽  
Shawn Phillips ◽  
Timothy Haddad ◽  
Alan Esker ◽  
Joe Polidan
Keyword(s):  
Thin Films ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Oligomeric Silsesquioxane

Polyhedral Oligomeric Silsesquioxane /Platelets Rich Plasma/Gelrite-Based Hydrogel Scaffold for Bone Tissue Engineering

2020 ◽  
Vol 26 (26) ◽  
pp. 3147-3160
Author(s):  
Saeedeh Ahmadipour ◽  
Jaleh Varshosaz ◽  
Batool Hashemibeni ◽  
Leila Safaeian ◽  
Maziar Manshaei
Keyword(s):  
Bone Fractures ◽  
Compressive Strain ◽  
Gelation Time ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Local Drug Delivery ◽  
Gelling Agent ◽  
Control Group ◽  
Hydrogel Scaffold ◽  
Alizarin Red ◽  
Oligomeric Silsesquioxane

Background: Polyhedral oligomeric silsesquioxane (POSS) is a monomer with silicon structure and an internal nanometric cage. Objective: The purpose of this study was to provide an injectable hydrogel that could be easily located in open or closed bone fractures and injuries, and also to reduce the possible risks of infections caused by bone graft either as an allograft or an autograft. Methods: Various formulations of temperature sensitive hydrogels containing hydroxyapatite, Gelrite, POSS and platelets rich plasma (PRP), such as the co-gelling agent and cell growth enhancer, were prepared. The hydrogels were characterized for their injectability, gelation time, phase transition temperature and viscosity. Other physical properties of the optimized formulation including compressive stress, compressive strain and Young’s modulus as mechanical properties, as well as storage and loss modulus, swelling ratio, biodegradation behavior and cell toxicity as rheometrical parameters were studied on human osteoblast MG-63 cells. Alizarin red tests were conducted to study the qualitative and quantitative osteogenic capability of the designed scaffold, and the cell adhesion to the scaffold was visualized by scanning electron microscopy. Results: The results demonstrated that the hydrogel scaffold mechanical force and injectability were 3.34±0.44 Mpa and 12.57 N, respectively. Moreover, the scaffold showed higher calcium granules production in alizarin red staining compared to the control group. The proliferation of the cells in G4.5H1P0.03PRP10 formulation was significantly higher than in other formulations (p<0.05). Conclusion: The optimized Gelrite/Hydroxyapatite/POSS/PRP hydrogel scaffold has useful impacts on osteoblasts activity, and may be beneficial for local drug delivery in complications including a break or bone loss.

scholarly journals Polyhedral oligomeric silsesquioxane (POSS)-modified phenolic resin: Synthesis and anti-oxidation properties

e-Polymers ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 316-326
Author(s):  
Bing Wang ◽  
Minxian Shi ◽  
Jie Ding ◽  
Zhixiong Huang
Keyword(s):  
Phenolic Resin ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Synthesis Process ◽  
H Nmr ◽  
Chemical Structures ◽  
Carbon Fiber Fabric ◽  
Oxidation Properties ◽  
Tg And Dtg ◽  
Oligomeric Silsesquioxane ◽  
Fiber Fabric

Abstract In this work, octamercapto polyhedral oligomeric silsesquioxane (POSS-8SH) and octaphenol polyhedral oligomeric silsesquioxane (POSS-8Phenol) were successfully synthetized. POSS-8Phenol was added into the synthesis process of liquid thermoset phenolic resin (PR) to obtain POSS-modified phenolic resin (POSS-PR). Chemical structures of POSS-8SH, POSS-8Phenol, and POSS-PR were confirmed by FTIR and 1H-NMR. TG and DTG analysis under different atmosphere showed that char yield of POSS-PR at 1,000°C increased from 58.6% to 65.2% in N2, which in air increased from 2.3% to 26.9% at 700°C. The maximum pyrolysis temperature in air increased from 543°C to 680°C, which meant better anti-oxidation properties. XRD results confirmed both POSS-8Phenol and POSS-PR-generated crystalline SiO2 in air, which could explain the improvement of anti-oxidation properties. SEM showed that the POSS-PR had phase separation during curing process. Finally, carbon fiber fabric-reinforced POSS-PR (C-POSS-PR) was prepared to verify the anti-oxidation properties of POSS-PR.

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