scholarly journals Metal-free and solvent-free synthesis of m-terphenyls through tandem cyclocondensation of aryl methyl ketones with triethyl orthoformate

RSC Advances ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 12113-12118 ◽  
Author(s):  
Xiaoqin Xiao ◽  
Juan Luo ◽  
Zongjie Gan ◽  
Wengao Jiang ◽  
Qiang Tang
Keyword(s):  
Solvent Free ◽  
Triethyl Orthoformate ◽  
Tandem Reaction ◽  
Methyl Ketones ◽  
One Pot ◽  
Metal Free ◽  
Solvent Free Synthesis ◽  
Aryl Methyl

A facile metal-free and solvent-free benzannulation was developed for the construction of m-terphenyl derivatives starting from aryl methyl ketones and triethyl orthoformate. This is a tandem reaction which merged six steps into one-pot procedure.

ChemInform Abstract: Solvent-Free Synthesis of 2H-Pyrans: One-Pot Reactions of Dithiocarbamates, Alkyl Propiolates, and Isocyanides.

ChemInform ◽  
2012 ◽  
Vol 43 (35) ◽  
pp. no-no
Author(s):  
Zinatossadat Hossaini ◽  
Faramarz Rostami-Charatib ◽  
Rahimeh Hajinasiria ◽  
Hojatollah Jafaryanc ◽  
Mehdi Shahrakid
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Solvent Free Synthesis ◽  
Alkyl Propiolates

Solvent-free synthesis of pyrrolo [2,1-α]isoquinolines via one-pot four-component reaction

2021 ◽  
Vol 18 ◽  
Author(s):  
Ali Aminkhani ◽  
Sina Sharifi
Keyword(s):  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

: An efficient four-component reaction to synthesize pyrrolo[2,1-a]isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.

A one-pot, three-component and solvent-free synthesis of 2,3-disubstituted isoindolin-1-ones

2015 ◽  
Vol 56 (33) ◽  
pp. 4729-4732 ◽  
Author(s):  
Mehdi Adib ◽  
Fariba Peytam ◽  
Mohsen Zainali ◽  
Long-Guan Zhu ◽  
Jing Wu
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Solvent Free Synthesis

scholarly journals One Pot Solvent-Free Synthesis of Benzodiazepinones Catalyzed by CuI

2017 ◽  
Vol 37 (4) ◽  
pp. 954
Author(s):  
Qingyang Zhang ◽  
Xiaojian Wang ◽  
Qiong Xiao ◽  
Dali Yin
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Solvent Free Synthesis

Use of Glycerol Carbonate in an Efficient, One-Pot and Solvent Free Synthesis of 1,3-sn-Diglycerides

2012 ◽  
Vol 90 (2) ◽  
pp. 259-264 ◽  
Author(s):  
Mojgan Kargar ◽  
Rahim Hekmatshoar ◽  
Mehdi Ghandi ◽  
AbdolJalil Mostashari
Keyword(s):  
Solvent Free ◽  
Glycerol Carbonate ◽  
One Pot ◽  
Solvent Free Synthesis

scholarly journals Solvent-free Synthesis of Nitriles from Aldehydes Catalyzed by KF/Al2O3, Montmorillonite KSF and K10

2006 ◽  
Vol 3 (3) ◽  
pp. 164-168
Author(s):  
Li-Jun Li ◽  
Ying-Xia Song ◽  
Yan-Su Gao ◽  
Yan-Feng Li ◽  
Jian-Feng Zhang
Keyword(s):  
Microwave Irradiation ◽  
Solvent Free ◽  
One Pot ◽  
Effective Catalyst ◽  
Multistep Procedure ◽  
Solvent Free Synthesis

Multistep and one-pot conversion of aldehydes to nitriles were carried out conveniently with out solvent using KF/Al2O3, montmorillonite KSF and K10 as catalyst, under microwave irradiation. The reactions are completed within 6-8 min to give satisfactory yields. KF/Al2O3was more effective catalyst both in multistep procedure and one-pot reaction.

Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N,N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2,4,6-Trisubstituted Pyridines

2015 ◽  
Vol 68 (2) ◽  
pp. 184 ◽  
Author(s):  
Benjamin Prek ◽  
Uroš Grošelj ◽  
Marta Kasunič ◽  
Silvo Zupančič ◽  
Jurij Svete ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Single Crystal ◽  
Ammonium Acetate ◽  
Dimethyl Acetal ◽  
Methyl Ketones ◽  
Closed Vessel ◽  
Simple Metal ◽  
One Pot ◽  
X Ray ◽  
Metal Free

Two metal-free syntheses of 2,4,6-trisubstituted pyridines 10a–m and 16a–j are described. N,N,6-Trimethyl-4-(substituted)pyridin-2-amines 10 were prepared from aryl or heteroaryl methyl ketones which were transformed with N,N-dimethylacetamide dimethyl acetal (DMADMA) into enaminones 4a–m, followed by treatment with ammonium acetate to give (Z)-3-amino-1-(substituted)but-2-en-1-ones 5a–m. These were treated with DMADMA under microwave irradiation in a closed vessel at 130°C, to give via intermediates 7–9 the final products 10a–m. N2,N2,N4,N4-Tetramethyl-6-(substituted) pyridine-2,4-diamines 16a–j were prepared in a one-pot synthesis from the corresponding carboxamides 11a–j by treatment with an excess of DMADMA in a closed vessel under microwave irradiation to give via intermediates 12a–j to 15a–j the final products 16a–j. X-Ray single crystal diffractometry studies of the enaminones 5c, 5g, 5i, 5j, and 5m and 2,4,6-trisubstituted pyridines 16a, 16b, 16g, 16i, and 16j were consistent with the expected structures.

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