scholarly journals Identification of key lipid metabolites during metabolic dysregulation in the diabetic retinopathy disease mouse model and efficacy of Keluoxin capsule using an UHPLC-MS-based non-targeted lipidomics approach

RSC Advances ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 5491-5505
Author(s):  
Nan Ge ◽  
Ling Kong ◽  
Ai-hua Zhang ◽  
Ye Sun ◽  
Man-qian Zhao ◽  
...  
Keyword(s):  
Young Adults ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Metabolic Dysregulation ◽  
Important Complication ◽  
The World ◽  
Lipid Metabolites

Diabetic retinopathy (DR) is an important complication of diabetes, and is currently the main cause of blindness among young adults in the world.

46-OR: A Novel Interaction between AT1 Receptor and Cytochrome-p450 Lipid Metabolites in Diabetic Retinopathy

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 46-OR
Author(s):  
MOHAMED AL-SHABRAWEY ◽  
AHMED IBRAHIM ◽  
AMANY M. TAWFIK ◽  
MONG HENG HENG WANG
Keyword(s):  
Diabetic Retinopathy ◽  
Cytochrome P450 ◽  
At1 Receptor ◽  
Lipid Metabolites

Acceptability of HIV testing for adolescents and young adults by delivery model: a systematic review

2021 ◽  
pp. jim-2021-002056
Author(s):  
Peter Thomas Leistikow ◽  
Vidhi Patel ◽  
Christian Nouryan ◽  
Joseph Steven Cervia
Keyword(s):  
Young Adults ◽  
North America ◽  
Care Delivery ◽  
Linkage To Care ◽  
Adolescents And Young Adults ◽  
Hiv Screening ◽  
Model Of Care ◽  
Delivery Model ◽  
Care Delivery Model ◽  
The World

HIV infections are prevalent among adolescents and young adults, of whom 44% remain unaware of their diagnosis. HIV screening presents numerous challenges including stigma, fear, and concerns about confidentiality, which may influence young people’s acceptance of HIV screening and linkage to care differently from individuals in other age groups. It is imperative to understand which care delivery models are most effective in facilitating these services for youth. This systematic review analyzes the rates of HIV test acceptance and linkage to care by care delivery model for adolescents and young adults. Studies were classified into emergency department (ED), primary care/inpatient setting, community-based program, or sexually transmitted infection clinic models of care. From 6395 studies initially identified, 59 met criteria for inclusion in the final analyses. Rate of test acceptance and linkage to care were stratified by model of care delivery, gender, race, age ranges (13–17, 18–24 years) as well as site (North America vs rest of the world). A significant difference in acceptance of HIV testing was found between care models, with high rates of test acceptance in the ED setting in North America and primary care/hospital setting in the rest of the world. Similarly, linkage to care differed by model of care, with EDs having high rates of linkages to HIV care in North America. Future studies are needed to test mechanisms for optimizing outcomes for each care delivery model in addressing the unique challenges faced by adolescents and young adults.

scholarly journals Diabetic retinopathy: An epidemic at home and around the world

2016 ◽  
Vol 64 (1) ◽  
pp. 69 ◽  
Author(s):  
Rajiv Raman ◽  
Laxmi Gella ◽  
Sangeetha Srinivasan ◽  
Tarun Sharma
Keyword(s):  
Diabetic Retinopathy ◽  
The World ◽  
At Home

scholarly journals A SINGLE CASE STUDY ON THE EFFECT OF AYURVEDIC MANAGEMENT IN TIMIRA W.S.R. TO MYOPIA – A CASE STUDY

2021 ◽  
Vol 9 (7) ◽  
pp. 1549-1554
Author(s):  
Kavita Rathore ◽  
Shamsa Fiaz
Keyword(s):  
Visual Acuity ◽  
Young Adults ◽  
Single Case ◽  
Single Case Study ◽  
Anatomical Structures ◽  
The World ◽  
Chief Complaints ◽  
Children And Young Adults ◽  
Defective Vision

Introduction - Myopia is the most common Refractive error of the eye seen in children and young adults and it has become more prevalent in recent years and is a cause of concern the world over. Myopia commonly referred to as near or shortsightedness. Some of the clinical features of Vataja Timira can be correlated with Myopia. Timira is counted under the Drishtigata Rogas [1] described by Sushruta. Timira involving first and second patala in terms of symptoms, anatomical structures involved and the pathogenesis of the disease. Timira begins with the blurring of vision gradually leading to the deterioration of eyesight. Shastrokta lakshanas of Vatika Timira such as bhramantiva sa pashyati, aavil darshan, vyaavidha darshan, aruna darshan [2]. Materials and Methods - A 20-year-old male, came to Shalakya Tantra OPD in National Institute of Ayurveda, deemed to be University Jaipur (R.J.), with chief complaints of defective vision for distance in both eyes, pain in both eyes and watering from both eyes since 4 months. He was treated with Nasya, Netra Pariseka, one sitting of Tarpana, Triphala guggulu, Patoladi eyedrops and Netramritam eyedrops. Result - At the end of the study, improvement in the visual acuity in both eyes, improvement in pain in both eyes and watering from both eyes have reduced. Conclusion -Thus, it can be concluded that Ayurvedic treatments are helpful to control Myopia. Keywords: Myopia, Nasya, Tarpana, Netra pariseka, Timira, Triphala Guggulu.

scholarly journals Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy

Diabetologia ◽  
2018 ◽  
Vol 61 (5) ◽  
pp. 1220-1232 ◽  
Author(s):  
Khaled Elmasry ◽  
Ahmed S. Ibrahim ◽  
Heba Saleh ◽  
Nehal Elsherbiny ◽  
Sally Elshafey ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Retinopathy ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Model ◽  
Microvascular Dysfunction

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

Science ◽  
2020 ◽  
Vol 369 (6506) ◽  
pp. eaay5356
Author(s):  
François Binet ◽  
Gael Cagnone ◽  
Sergio Crespo-Garcia ◽  
Masayuki Hata ◽  
Mathieu Neault ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Vascular Remodeling ◽  
Neutrophil Extracellular Traps ◽  
Developed Countries ◽  
Sterile Inflammation ◽  
Extracellular Traps ◽  
Retinal Blood Vessels ◽  
Underlying Mechanisms

In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we used orthogonal approaches in human patients with proliferative diabetic retinopathy and a mouse model of ischemic retinopathies to identify an unconventional role for neutrophils in vascular remodeling during late-stage sterile inflammation. Senescent vasculature released a secretome that attracted neutrophils and triggered the production of neutrophil extracellular traps (NETs). NETs ultimately cleared diseased endothelial cells and remodeled unhealthy vessels. Genetic or pharmacological inhibition of NETosis prevented the regression of senescent vessels and prolonged disease. Thus, clearance of senescent retinal blood vessels leads to reparative vascular remodeling.

scholarly journals Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mitsuru Arima ◽  
Dan Cui ◽  
Tokuhiro Kimura ◽  
Koh-Hei Sonoda ◽  
Tatsuro Ishibashi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Therapeutic Target ◽  
Barrier Function

Suicide note in the ligature material- a case report

2017 ◽  
Vol 3 (02) ◽  
Author(s):  
Mithun Ghosh ◽  
Bhim Singh
Keyword(s):  
Young Adults ◽  
Case Report ◽  
Cause Of Death ◽  
Left Behind ◽  
The World ◽  
Suicide Note

Suicide is a leading cause of death among young adults. About a million suicides occur annually throughout the world. A suicide note is often found at the scene. It has been reported that a note was left in 5%-43% of the suicides (1). The content of a suicide note includesapology, shame, guilt, love for those left behind and instruction regarding practical affairs (2). It is an important tool for medico-legal investigation on the manner and circumstances surrounding the death. The victim generally writes them on a paper, notebook, wall, or mirror by means of pen or marker (3). We present a case where asuicide note was recovered from the ligature itself. This method of keeping a suicide note in the ligature is unique and rarely found in the literature.

scholarly journals Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy

2015 ◽  
Vol 56 (1) ◽  
pp. 606-615 ◽  
Author(s):  
B. A. Berkowitz ◽  
E. M. Grady ◽  
N. Khetarpal ◽  
A. Patel ◽  
R. Roberts
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Posterior Segment ◽  
Evoked Responses

scholarly journals Prevalence of diabetic retinopathy in young adults with type 1 diabetes since childhood: the Oulu cohort study of diabetic retinopathy

2014 ◽  
Vol 92 (8) ◽  
pp. 749-752 ◽  
Author(s):  
Nina Hautala ◽  
Virva Hannula ◽  
Tapani Palosaari ◽  
Tapani Ebeling ◽  
Aura Falck
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Diabetic Retinopathy ◽  
Cohort Study
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