Recent advances on asymmetric transformations of achiral cyclohexadienones

2020 ◽  
Author(s):  
Bo Chen ◽  
Cheng-Yu He ◽  
Wen-Dao Chu ◽  
Quanzhong Liu
Keyword(s):  
Natural Products ◽  
Kinetic Resolution ◽  
Asymmetric Transformations ◽  
Bioactive Natural Products ◽  
Recent Advances

Enantioselective desymmetrization of prochiral cyclohexadienones and kinetic resolution of racemic cyclohexadienones are powerful strategies for the construction of enantiomerically enriched cyclohexanone-containing molecules, which are frequently found in bioactive natural products....

ChemInform Abstract: Recent Advances in the Synthesis of Bioactive Natural Products

ChemInform ◽  
2010 ◽  
Vol 28 (12) ◽  
pp. no-no
Author(s):  
A. G. M. BARRETT ◽  
W. W. DOUBLEDAY ◽  
K. KASDORF ◽  
M. PENA ◽  
G. J. TUSTIN ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Natural Products ◽  
Recent Advances

Recent advances in the synthesis of bioactive natural products

1996 ◽  
Vol 33 (5) ◽  
pp. 1545-1550 ◽  
Author(s):  
A. G. M. Barrett ◽  
W. W. Doubleday ◽  
K. Kasdorf ◽  
M. Pena ◽  
G. J. Tustin ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Natural Products ◽  
Recent Advances

scholarly journals Catalytic asymmetric C–Si bond activation via torsional strain-promoted Rh-catalyzed aryl-Narasaka acylation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jia Feng ◽  
Xiufen Bi ◽  
Xiaoping Xue ◽  
Na Li ◽  
Lei Shi ◽  
...  
Keyword(s):  
Natural Products ◽  
Ring Opening ◽  
Kinetic Resolution ◽  
Bond Activation ◽  
Bond Cleavage ◽  
Catalytic Synthesis ◽  
Torsional Strain ◽  
Silanol Groups ◽  
Bioactive Natural Products ◽  
Ring Opening Reaction

Abstract Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed torsional strain-promoted asymmetric ring-opening reaction for the synthesis of α-silyl biaryl atropisomers. The reaction features a dynamic kinetic resolution of C(Ar)-Si bond cleavage, whose stereochemistry was controlled by a phosphoramidite ligand derived from (S)-3-methyl-1-((2,4,6-triisopropylphenyl)sulfonyl)piperazine. This work is a demonstration of an aryl-Narasaka acylation, where the C(Ar)-Si bond cleavage is promoted by the torsional strain of α, α’-disubstituted silafluorene.

Recent Advances in Separation of Bioactive Natural Products

2013 ◽  
Vol 21 (9) ◽  
pp. 937-952 ◽  
Author(s):  
Qilong REN ◽  
Huabin XING ◽  
Zongbi BAO ◽  
Baogen SU ◽  
Qiwei YANG ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Natural Products ◽  
Recent Advances

scholarly journals Recent Advances in the Regioselective Synthesis of Indoles via C–H Activation/Functionalization

Synthesis ◽  
2018 ◽  
Vol 50 (14) ◽  
pp. 2655-2677 ◽  
Author(s):  
Upendra Sharma ◽  
Inder Kumar ◽  
Rakesh Kumar
Keyword(s):  
Natural Products ◽  
Regioselective Synthesis ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
Recent Advances ◽  
Metal Catalyzed ◽  
Indole Synthesis

Indole is an important heterocyclic motif that occurs ubiquitously in bioactive natural products and pharmaceuticals. Immense efforts have been devoted to the synthesis of indoles starting from the Fisher indole synthesis to the recently developed C–H activation/functionalization-based methods. Herein, we have reviewed the progress made on the regioselective synthesis of functionalized indoles, including 2-substituted, 3-substituted and 2,3-disusbstituted indoles, since the year 2010.1 Introduction2 Metal-Catalyzed Synthesis of 2-Substituted Indoles3 Metal-Catalyzed Synthesis of 3-Substituted Indoles4 Metal-Free Synthesis of 3-Substituted Indoles5 Metal-Catalyzed 2,3-Disubstituted Indole Synthesis5.1 Metal-Catalyzed Intramolecular 2,3-Disubstituted Indole Synthesis5.2 Metal-Catalyzed Intermolecular 2,3-Disubstituted Indole Synthesis6 Metal-Free 2,3-Disubstituted Indole Synthesis6.1 N-Protected 2,3-Disubstituted Indole Synthesis6.2 N-Unprotected 2,3-Disubstituted Indole Synthesis7 Applications8 Summary and Outlook

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