Ni(II), Cu(II) and Zn(II) Complexes with 1-Trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine Ligand Simultaneously Target Microtubule and Mitochondria for Cancer Therapy

2021 ◽  
Author(s):  
Liao Lan-Shan ◽  
Yin Chen ◽  
Zu-Yu Mo ◽  
Cheng Hou ◽  
Gui-Fa SU ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes ◽  
Anticancer Activity

Metal complexes of [NiL2(NO3)2] (1), [CuL2(NO3)2] (2) and [ZnL2(NO3)2] (3) with 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine (L) ligand were synthesized. We discovered that complexes 13 exhibited considerable anticancer activity in vitro via simultaneously targeting...

Enhancement in intramolecular interactions and in vitro biological activity of a tripodal tetradentate system upon complexation

2015 ◽  
Vol 44 (35) ◽  
pp. 15591-15601 ◽  
Author(s):  
Nidhi Tyagi ◽  
Mambattakkara Viji ◽  
Suneesh C. Karunakaran ◽  
Sunil Varughese ◽  
Shilpa Ganesan ◽  
...  
Keyword(s):  
Biological Activity ◽  
Metal Complexes ◽  
Anticancer Activity ◽  
Intramolecular Interactions

Naphthalimide appended metal complexes uniquely exhibited intramolecular interactions, affinity for DNA/proteins and apoptosis mediated anticancer activity.

scholarly journals Anticancer Activity of Electron‐Deficient Metal Complexes against Colorectal Cancer in vitro Models

ChemMedChem ◽  
2019 ◽  
Vol 14 (22) ◽  
pp. 1887-1893 ◽  
Author(s):  
Maria Azmanova ◽  
Joan Soldevila‐Barreda ◽  
Hira Bani Hani ◽  
Rianne M. Lord ◽  
Anaïs Pitto‐Barry ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metal Complexes ◽  
Anticancer Activity ◽  
In Vitro Models

Polymeric prodrugs conjugated with reduction-sensitive dextran–camptothecin and pH-responsive dextran–doxorubicin: an effective combinatorial drug delivery platform for cancer therapy

2016 ◽  
Vol 7 (25) ◽  
pp. 4198-4212 ◽  
Author(s):  
Dongling Cao ◽  
Jinlin He ◽  
Jiaying Xu ◽  
Mingzu Zhang ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Activity ◽  
Ph Responsive ◽  
Delivery Platform ◽  
Stimuli Sensitive

Two types of stimuli-sensitive polymeric prodrugs for combinatorial cancer therapy have been prepared and found to exhibit favorable anticancer activity in vitro and in vivo.

scholarly journals Novel Papaverine Metal Complexes with Potential Anticancer Activities

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5447
Author(s):  
Ahmed Gaber ◽  
Walaa F. Alsanie ◽  
Deo Nandan Kumar ◽  
Moamen S. Refat ◽  
Essa M. Saied
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Metal Complexes ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anticancer Activities ◽  
Mcf 7

Cancer is one of the leading causes of death worldwide. Although several potential therapeutic agents have been developed to efficiently treat cancer, some side effects can occur simultaneously. Papaverine, a non-narcotic opium alkaloid, is a potential anticancer drug that showed selective antitumor activity in various tumor cells. Recent studies have demonstrated that metal complexes improve the biological activity of the parent bioactive ligands. Based on those facts, herein we describe the synthesis of novel papaverine–vanadium(III), ruthenium(III) and gold(III) metal complexes aiming at enhancing the biological activity of papaverine drug. The structures of the synthesized complexes were characterized by various spectroscopic methods (IR, UV–Vis, NMR, TGA, XRD, SEM). The anticancer activity of synthesized metal complexes was evaluated in vitro against two types of cancer cell lines: human breast cancer MCF-7 cells and hepatocellular carcinoma HepG-2 cells. The results revealed that papaverine-Au(III) complex, among the synthesized complexes, possess potential antimicrobial and anticancer activities. Interestingly, the anticancer activity of papaverine–Au(III) complex against the examined cancer cell lines was higher than that of the papaverine alone, which indicates that Au-metal complexation improved the anticancer activity of the parent drug. Additionally, the Au complex showed anticancer activity against the breast cancer MCF-7 cells better than that of cisplatin. The biocompatibility experiments showed that Au complex is less toxic than the papaverine drug alone with IC50 ≈ 111 µg/mL. These results indicate that papaverine–Au(III) complex is a promising anticancer complex-drug which would make it a suitable candidate for further in vivo investigations.

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