Bis-heteroleptic Ru(ii) polypyridine complex-based luminescent probes for nerve agent simulant and organophosphate pesticide

2021 ◽  
Author(s):  
Bhaskar Sen ◽  
Monosh Rabha ◽  
Sanjoy Kumar Sheet ◽  
Debaprasad Koner ◽  
Nirmalendu Saha ◽  
...  
Keyword(s):  
Nerve Agent ◽  
Organophosphate Pesticide ◽  
Luminescent Probes ◽  
Phenanthroline Ligand

Two bis-heteroleptic Ru(ii) complexes of a 4,7-dihydroxy-1,10-phenanthroline ligand were synthesized for the detection of the nerve agent gas mimic, DCP, and the organophosphate pesticide, dichlorvos, through the “off–on” luminescence response.

Neurotrophin Expression in Nerve Agent VX-Exposed Rat Brain

2007 ◽  
Author(s):  
Santresda M. Johnson ◽  
Chris L. Robison ◽  
Tsung-Ming A. Shih ◽  
Lawrence Tong ◽  
Sarah Parylak ◽  
...  
Keyword(s):  
Rat Brain ◽  
Nerve Agent

Iridium-Catalyzed Silylation of C-H bonds in Unactivated Arenes: A Sterically-Encumbered Phenanthroline Ligand Accelerates Catalysis Enabling New Reactivity

2019 ◽  
Author(s):  
Caleb Karmel ◽  
Zhewei Chen ◽  
John Hartwig
Keyword(s):  
High Activity ◽  
Functional Group ◽  
Activity Analysis ◽  
High Reactivity ◽  
High Yield ◽  
Phen Ligand ◽  
Mechanistic Studies ◽  
Phenanthroline Ligand ◽  
First Time ◽  
New System

We report a new system for the silylation of aryl C-H bonds. The combination of [Ir(cod)(OMe)]<sub>2</sub> and 2,9-Me<sub>2</sub>-phenanthroline (2,9-Me<sub>2</sub>phen) catalyzes the silylation of arenes at lower temperatures and with faster rates than those reported previously, when the hydrogen byproduct is removed, and with high functional group tolerance and regioselectivity. Inhibition of reactions by the H<sub>2</sub> byproduct is shown to limit the silylation of aryl C-H bonds in the presence of the most active catalysts, thereby masking their high activity. Analysis of initial rates uncovered the high reactivity of the catalyst containing the sterically hindered 2,9-Me<sub>2</sub>phen ligand but accompanying rapid inhibition by hydrogen. With this catalyst, under a flow of nitrogen to remove hydrogen, electron-rich arenes, including those containing sensitive functional groups, undergo silylation in high yield for the first time, and arenes that underwent silylation with prior catalysts react over much shorter times with lower catalyst loadings. The synthetic value of this methodology is demonstrated by the preparation of key intermediates in the synthesis of medicinally important compounds in concise sequences comprising silylation and functionalization. Mechanistic studies demonstrate that the cleavage of the aryl C-H bond is reversible and that the higher rates observed with the 2,9-Me<sub>2</sub>phen ligand is due to a more thermodynamically favorable oxidative addition of aryl C-H bonds.

The Role of DARPP-32, an Intracellular Signaling Molecule, in the Actions of the Nerve Agent Sarin

2005 ◽  
Author(s):  
Tsung-Ming Shih ◽  
Gretchen L. Snyder ◽  
Allen A. Fienberg ◽  
Stacey Galdi ◽  
Minal Rana ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Nerve Agent ◽  
Signaling Molecule

Evaluation of ADD392124 for the Delayed Treatment of Nerve Agent-Induced Status Epilepticus Seizures

2011 ◽  
Author(s):  
John H. McDonough ◽  
Kerry E. Van Shura ◽  
Megan E. Lyman ◽  
Claire G. Eisner ◽  
Amelia Mazza ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Nerve Agent ◽  
Delayed Treatment

KLa(0.95−x)GdxF4:Eu3+ hexagonal phase nanoparticles as luminescent probes for in vitro Huh-7 cancer cell imaging

2021 ◽  
Vol 50 (15) ◽  
pp. 5197-5207
Author(s):  
Mohini Gupta ◽  
Rajamani Nagarajan ◽  
Chitteti Ramamurthy ◽  
Perumal Vivekanandan ◽  
G. Vijaya Prakash
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Imaging ◽  
Hexagonal Phase ◽  
Liver Cancer Cell ◽  
Luminescent Probes ◽  
Cancer Cell Imaging ◽  
Site Selective

Strong and site selective red-emitting photoluminescent/MRI multi-functional KLa(0.95−x)GdxF4:Eu3+ (x = 0–0.4) bio-compatible nanomaterials for targeted in-vitro liver cancer cell imaging.

scholarly journals Mechanistic Insight of Sensing Hydrogen Phosphate in Aqueous Medium by Using Lanthanide(III)-Based Luminescent Probes

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 53
Author(s):  
Jashobanta Sahoo ◽  
Santlal Jaiswar ◽  
Pabitra B. Chatterjee ◽  
Palani S. Subramanian ◽  
Himanshu Sekhar Jena
Keyword(s):  
Drug Discovery ◽  
Aqueous Medium ◽  
Hydrogen Phosphate ◽  
Heterocyclic Ligand ◽  
Luminescent Probes ◽  
Mechanistic Insight ◽  
Sensitivity And Selectivity ◽  
Spectrophotometric Titrations ◽  
Ethanesulfonic Acid ◽  
High Degree

The development of synthetic lanthanide luminescent probes for selective sensing or binding anions in aqueous medium requires an understanding of how these anions interact with synthetic lanthanide probes. Synthetic lanthanide probes designed to differentiate anions in aqueous medium could underpin exciting new sensing tools for biomedical research and drug discovery. In this direction, we present three mononuclear lanthanide-based complexes, EuLCl3 (1), SmLCl3 (2), and TbLCl3 (3), incorporating a hexadentate aminomethylpiperidine-based nitrogen-rich heterocyclic ligand L for sensing anion and establishing mechanistic insight on their binding activities in aqueous medium. All these complexes are meticulously studied for their preferential selectivities towards different anions such as HPO42−, SO42−, CH3COO−, I−, Br−, Cl−, F−, NO3−, CO32−/HCO3−, and HSO4− at pH 7.4 in aqueous HEPES (2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid) buffer. Among the anions scanned, HPO42− showed an excellent luminescence change with all three complexes. Job’s plot and ESI-MS support the 1:2 association between the receptors and HPO42−. Systematic spectrophotometric titrations of 1–3 against HPO42− demonstrates that the emission intensities of 1 and 2 were enhanced slightly upon the addition of HPO42− in the range 0.01–1 equiv and 0.01–2 equiv., respectively. Among the three complexes, complex 3 showed a steady quenching of luminescence throughout the titration of hydrogen phosphate. The lower and higher detection limits of HPO42− by complexes 1 and 2 were determined as 0.1–4 mM and 0.4–3.2 mM, respectively, while complex 3 covered 0.2–100 μM. This concludes that all complexes demonstrated a high degree of sensitivity and selectivity towards HPO42−.

Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX

2021 ◽  
Vol 419 ◽  
pp. 115512
Author(s):  
E. Wigenstam ◽  
E. Forsberg ◽  
A. Bucht ◽  
L. Thors
Keyword(s):  
Nerve Agent

scholarly journals The design of responsive luminescent lanthanide probes and sensors

2021 ◽  
Author(s):  
David Parker ◽  
Jack D. Fradgley ◽  
Ka-Leung Wong
Keyword(s):  
Design Principles ◽  
Luminescent Probes ◽  
The Creation

The design principles that guide the creation of responsive lanthanide luminescent probes are defined, classified and exemplified.

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