Synthesis of azobenzene-containing liquid crystalline block copolymer nanoparticles via polymerization induced hierarchical self-assembly

2021 ◽  
Author(s):  
Wei Wen ◽  
Wangqi Ouyang ◽  
Song Guan ◽  
Aihua Chen
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Facile Synthesis ◽  
Liquid Crystalline Nanoparticles

A facile synthesis of non-spherical photoresponsive azobenzene-containing liquid crystalline nanoparticles via polymerization-induced hierarchical self-assembly (PIHSA).

Bulk self-assembly and ionic conductivity of a block copolymer containing an azobenzene-based liquid crystalline polymer and a poly(ionic liquid)

2017 ◽  
Vol 8 (10) ◽  
pp. 1689-1698 ◽  
Author(s):  
Yu-Dong Zhang ◽  
Jing Ping ◽  
Qi-Wei Wu ◽  
Hong-Bing Pan ◽  
Xing-He Fan ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Block Copolymer ◽  
Ionic Conductivity ◽  
Solid Electrolyte ◽  
Self Assembly ◽  
Liquid Crystalline Polymer ◽  
Liquid Crystalline ◽  
Crystalline Polymer ◽  
Poly Ionic Liquid

A block copolymer containing a liquid crystalline polymer and a poly(ionic liquid) self-assembles and can be used as a solid electrolyte.

scholarly journals Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1400 ◽  
Author(s):  
Maria Chountoulesi ◽  
Natassa Pippa ◽  
Varvara Chrysostomou ◽  
Stergios Pispas ◽  
Evangelia D. Chrysina ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Liquid Crystalline ◽  
Polymer Concentration ◽  
Morphological Characteristics ◽  
Amphiphilic Block Copolymer ◽  
Poloxamer 407 ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Liquid Crystalline Nanoparticles

There is an emerging need to evolve the conventional lyotropic liquid crystalline nanoparticles to advanced stimuli-responsive, therapeutic nanosystems with upgraded functionality. Towards this effort, typically used stabilizers, such as Pluronics®, can be combined or replaced by smart, stimuli-responsive block copolymers. The aim of this study is to incorporate the stimuli-responsive amphiphilic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) as a stabilizer in lipidic liquid crystalline nanoparticles, in order to provide steric stabilization and simultaneous stimuli-responsiveness. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by light scattering techniques, cryogenic-transmission electron microscopy (cryo-TEM), X-ray diffraction (XRD) and fluorescence spectroscopy. The PDMAEMA-b-PLMA, either individually or combined with Poloxamer 407, exhibited different modes of stabilization depending on the lipid used. Due to the protonation ability of PDMAEMA blocks in acidic pH, the nanoparticles exhibited high positive charge, as well as pH-responsive charge conversion, which can be exploited towards pharmaceutical applications. The ionic strength, temperature and serum proteins influenced the physicochemical behavior of the nanoparticles, while the polymer concentration differentiated their morphology; their micropolarity and microfluidity were also evaluated. The proposed liquid crystalline nanosystems can be considered as novel and attractive pH-responsive drug and gene delivery nanocarriers due to their polycationic content.

scholarly journals Self-assembly of a silicon-containing side-chain liquid crystalline block copolymer in bulk and in thin films: kinetic pathway of a cylinder to sphere transition

Nanoscale ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 285-293 ◽  
Author(s):  
Fen Liao ◽  
Ling-Ying Shi ◽  
Li-Chen Cheng ◽  
Sangho Lee ◽  
Rong Ran ◽  
...  
Keyword(s):  
Thin Films ◽  
Block Copolymer ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Side Chain ◽  
Kinetic Transition

Hierarchical morphologies and transitions of a silicon-containing LCBCP were investigated and the kinetic transition from HEX to BCC is described.

Physicochemical and Drug Delivery Aspects of Lipid-Based Liquid Crystalline Nanoparticles: A Case Study of Intravenously Administered Propofol

2006 ◽  
Vol 6 (9) ◽  
pp. 3017-3024 ◽  
Author(s):  
Markus Johnsson ◽  
Justas Barauskas ◽  
Andreas Norlin ◽  
Fredrik Tiberg
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Drug Loading ◽  
Drug Substances ◽  
Physicochemical Features ◽  
Liquid Crystalline Nanoparticles ◽  
Effect Duration

Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including: higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration.

Chemically directed self-assembly of perpendicularly aligned cylinders by a liquid crystalline block copolymer

2015 ◽  
Vol 3 (12) ◽  
pp. 2837-2847 ◽  
Author(s):  
N. Yamashita ◽  
S. Watanabe ◽  
K. Nagai ◽  
M. Komura ◽  
T. Iyoda ◽  
...  
Keyword(s):  
Thin Film ◽  
Block Copolymer ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Microphase Separation ◽  
Thermally Induced ◽  
Multiplication Process

Chemical epitaxy with a density multiplication process was applied to the perpendicularly oriented hexagonal cylinder nanostructure of liquid crystalline block copolymer (PEO-b-PMA(Az)) thin film through thermally induced microphase separation by using a newly designed PMA(Az)24 brush.

scholarly journals Thin Film Self-Assembly of a Silicon-Containing Rod–Coil Liquid Crystalline Block Copolymer

2019 ◽  
Vol 52 (2) ◽  
pp. 679-689 ◽  
Author(s):  
Ling-Ying Shi ◽  
Sangho Lee ◽  
Li-Chen Cheng ◽  
Hejin Huang ◽  
Fen Liao ◽  
...  
Keyword(s):  
Thin Film ◽  
Block Copolymer ◽  
Self Assembly ◽  
Liquid Crystalline

scholarly journals Synthesis and characterization of a new hydrogen bonded side chain liquid crystal block copolymer and investigation of electrical properties

2017 ◽  
Vol 89 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Burak Korkmaz ◽  
Esma Ahlatcıoğlu Özerol ◽  
Ayşegül Çelik Bozdoğan ◽  
Mustafa Okutan ◽  
Bahire Filiz Şenkal ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Hydroxyl Group ◽  
Side Chain ◽  
Complex Dielectric Constant ◽  
Hydrogen Bond Formation ◽  
Crystal Block ◽  
Poly Ethylene ◽  
Methacrylate Copolymer

AbstractA new PEG-containing liquid crystalline side chain block copolymer HBC-PEG550 was prepared from poly(ethylene glycol)-b-poly(2-(diethylamino) ethyl methacrylate copolymer (BC-PEG550) and 8-(4-cyanobiphenyl-4′-oxy) octan-1-ol (LC8) by molecular self-assembly processes via hydrogen bond formation between amine group of HBC-PEG550 and hydroxyl group of the LC8. The formation of H bond was confirmed by using FTIR spectroscopy. The liquid crystalline behavior of the HBC-PEG550 was investigated by differential scanning calorimeter (DSC) and polarized optical microscopy. Dielectric properties of HBC-PEG550 and HBC-PEG550 has been studied by impedance spectroscopy. Real and imaginary parts of complex dielectric constant, impedance, and energy loss tangent factor for HBC-PEG550 and HBC-PEG550 have been characterized in the frequency range of 100 Hz–15 MHz.

A facile synthesis of pH stimuli biocompatible block copolymer poly(methacrylic acid)-block-poly(N-vinylpyrrolidone) utilizing switchable RAFT agents

2019 ◽  
Vol 10 (16) ◽  
pp. 2083-2090 ◽  
Author(s):  
Xiangyu Pan ◽  
Xiaofeng Guo ◽  
Bonnie Choi ◽  
Anchao Feng ◽  
Xiaohu Wei ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Methacrylic Acid ◽  
Self Assembly ◽  
Facile Synthesis ◽  
Copolymer Poly

Synthesis of block copolymer PMAA-b-PNVP utilizing switchable RAFT agents and its self-assembly.

scholarly journals Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy

2020 ◽  
Vol 19 (5) ◽  
pp. 674-680
Author(s):  
Sébastien Jenni ◽  
Giacomo Picci ◽  
Marco Fornasier ◽  
Marianna Mamusa ◽  
Judith Schmidt ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Cancer Therapy ◽  
Liquid Crystalline ◽  
Antineoplastic Drug ◽  
Pluronic F108 ◽  
Liquid Crystalline Nanoparticles ◽  
Potential Cancer

Multifunctional lipidic cubic liquid crystalline nanoparticles for potential cancer therapy were engineered by conjugating a porphyrin-based photosensitizer to the block copolymer Pluronic F108 and loading them with the antineoplastic drug Docetaxel.

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