An advanced micelle-based biodegradable HPMA polymer-gadolinium contrast agent for MR imaging of murine vasculatures and tumors

2020 ◽  
Vol 11 (39) ◽  
pp. 6374-6386
Author(s):  
Haonan Li ◽  
Qiang Luo ◽  
Hongyan Zhu ◽  
Zhiqian Li ◽  
Xiaoming Wang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Polymeric Micelle ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent ◽  
Vascular Structures

A biodegradable HPMA polymeric micelle-based MR contrast agent containing gadolinium (Gd3+) for imaging murine vascular structures and tumors.

Gadolinium Contrast Agent Selection and Optimal Use for Body MR Imaging

2014 ◽  
Vol 52 (4) ◽  
pp. 637-656 ◽  
Author(s):  
Flavius F. Guglielmo ◽  
Donald G. Mitchell ◽  
Shiva Gupta
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent ◽  
Agent Selection

MR imaging in chronic achilles tendon disorder

1998 ◽  
Vol 39 (2) ◽  
pp. 126-132 ◽  
Author(s):  
T. Movin ◽  
M. Kristoffersen-Wiberg ◽  
C. Rolf ◽  
P. Aspelin
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Achilles Tendon ◽  
Clinical Symptoms ◽  
Histopathological Examination ◽  
Primary Objective ◽  
Proton Density ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent ◽  
Signal Abnormality

Objectives: the primary objective was to compare 4 imaging sequences (T1-weighted, T2-weighted, proton density, and T1-weighted with gadolinium contrast agent enhancement) with regard to intratendinous signal abnormality in patients with achillodynia. the secondary objective was to relate the images to the clinical symptoms and histopathological findings Material and Methods: Twenty patients (16 men, 4 women, median age 40 years) with chronic achillodynia participated in the study. the symptoms prohibited activity and clinical examination revealed swelling and tenderness 1.5–6 cm proximal to the Achilles tendon insertion. of the 20 patients: 5 had bilateral achillodynia, 4 had had previous contralateral Achilles tendon disorder, and 11 had never had symptoms in the contralateral tendon region. These 11 tendons served as controls for comparison MR imaging was performed on a superconductive 1.5 T unit. Both Achilles tendons were examined (n=40) at the same time, and multiple sagittal and transversal images were obtained. the corresponding sections on these images were visually graded according to both extension and level of MR signal intensity. Tissue was obtained for microscopic examination from the most symptomatic side in all patients (n=20) Results: T1-weighted images following gadolinium contrast medium enhancement proved to be the best method by which to visualize intratendinous signal abnormality. This sequence revealed signal abnormality in 24/25 symptomatic tendons and in 1/11 control tendons ( p>0.001). Histopathological examination showed an increased noncollagenous extracellular matrix and altered fiber structure in the lesions corresponding to the contrast-enhanced areas Conclusion: Gadolinium enhancement improved the imaging of intratendinous signal abnormality on T1-weighted images. There was a high level of extracellular glycosaminoglycans, which are highly-fixed negatively-charged macromolecules with extreme water-retaining capacity and which may have contributed to the enhancement by the gadolinium contrast agent

Gadolinium contrast agent is of limited value for magnetic resonance imaging assessment of synovial hypertrophy in hemophiliacs

2007 ◽  
Vol 48 (5) ◽  
pp. 520-530 ◽  
Author(s):  
B. Lundin ◽  
E. Berntorp ◽  
H. Pettersson ◽  
R. Wirestam ◽  
K. Jonsson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Dynamic Mri ◽  
Time Interval ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Gadolinium Contrast ◽  
Synovial Hypertrophy ◽  
Gadolinium Contrast Agent

Purpose: To examine the influence of different doses of gadolinium contrast agent on synovial enhancement, to compare magnetic resonance imaging (MRI) findings of synovial hypertrophy and radiographic joint changes in hemophiliacs, and to investigate the value of gadolinium in MRI assessment of synovial hypertrophy in hemophiliacs using dynamic MRI and MRI scoring. Material and Methods: Twenty-one hemophiliacs on prophylactic factor treatment without recent bleeds were subjected to radiography and gadolinium contrast-enhanced dynamic and static MRI of the knee using a standard dose of 0.1 mmol/kg b.w. gadoteridol. In 17 of the patients, the MRI procedure was repeated after a triple dose of gadoteridol. Results: MRI findings of synovial hypertrophy were significantly correlated with Pettersson radiographic scores. In 19 of the 21 MRI investigated joints, administration of contrast agent did not alter the result of the evaluation of synovial hypertrophy. Conclusion: The optimal time interval for volume assessment of synovial hypertrophy after injection of gadolinium contrast agent is dose dependent. Hemophiliacs without recent bleeds have minor to abundant synovial hypertrophy in joints with pronounced radiographic changes. Dynamic MRI is not useful for evaluating hemophilic arthropathy, and gadolinium contrast agent is not routinely indicated for MRI scoring of joints in hemophiliacs.

Magnetic Resonance Imaging Demonstration of Pharmacologic-Induced Myocardial Vasodilatation Using a Macromolecular Gadolinium Contrast Agent

1992 ◽  
Vol 27 (11) ◽  
pp. 935-940 ◽  
Author(s):  
VLADIMIR S. VEXLER ◽  
YVES BERTHEZÈNE ◽  
CHRISTOPHER L. WOLFE ◽  
RICHARD SIEVERS ◽  
JEAN W. DUPON ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent
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