Folded amphiphilic homopolymer micelles in water: uniform self-assembly beyond amphiphilic random copolymers

2020 ◽  
Vol 11 (32) ◽  
pp. 5156-5162 ◽  
Author(s):  
Yoshihiko Kimura ◽  
Makoto Ouchi ◽  
Takaya Terashima
Keyword(s):  
Self Assembly ◽  
Random Copolymers ◽  
Assembly Systems ◽  
Amphiphilic Homopolymers

Herein, we developed precision self-assembly systems of amphiphilic homopolymers into folded micelles in water.

Programmed Self-Assembly Systems of Amphiphilic Random Copolymers into Size-Controlled and Thermoresponsive Micelles in Water

2018 ◽  
Vol 51 (2) ◽  
pp. 398-409 ◽  
Author(s):  
Shota Imai ◽  
Yuji Hirai ◽  
Chitose Nagao ◽  
Mitsuo Sawamoto ◽  
Takaya Terashima
Keyword(s):  
Self Assembly ◽  
Random Copolymers ◽  
Assembly Systems ◽  
Size Controlled

Orientation- and cosolvent-induced self-assembly of amphiphilic homopolymers in selective solvents

Polymer ◽  
2021 ◽  
Vol 232 ◽  
pp. 124160
Author(s):  
Aleksandr I. Buglakov ◽  
Daniil E. Larin ◽  
Valentina V. Vasilevskaya
Keyword(s):  
Self Assembly ◽  
Selective Solvents ◽  
Amphiphilic Homopolymers

scholarly journals Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Luo ◽  
Yujuan Gao ◽  
Zhongyu Duan ◽  
Yu Yi ◽  
Hao Wang
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Recent Progress ◽  
Assembly Systems ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
Self Assembling ◽  
Stimuli Response

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

Constructive Molecular Dynamics Lattice Gases: Three-Dimensional Molecular Self-Assembly

2003 ◽  
Author(s):  
Martin Nilsson ◽  
Steen Rasmussen
Keyword(s):  
Molecular Dynamics ◽  
Self Assembly ◽  
Lattice Gas ◽  
Chemical Properties ◽  
Special Kind ◽  
Lattice Gases ◽  
Living Systems ◽  
Self Organization ◽  
Assembly Systems ◽  
Formal Systems

Realistic molecular dynamics and self-assembly is represented in a lattice simulation where water, water-hydrocarbons, and water-amphiphilic systems are investigated. The details of the phase separation dynamics and the constructive self-assembly dynamics are discussed and compared to the corresponding experimental systems. The method used to represent the different molecular types can easily be expended to include additional molecules and thus allow the assembly of more complex structures. This molecular dynamics (MD) lattice gas fills a modeling gap between traditional MD and lattice gas methods. Both molecular objects and force fields are represented by propagating information particles and all microscopic interactions are reversible. Living systems, perhaps the ultimate constructive dynamical systems, is the motivation for this work and our focus is a study of the dynamics of molecular self-assembly and self-organization. In living systems, matter is organized such that it spontaneously constructs intricate functionalities at all levels from the molecules up to the organism and beyond. At the lower levels of description, chemical reactions, molecular selfassembly and self-organization are the drivers of this complexity. We shall, in this chapter, demonstrate how molecular self-assembly and selforganization processes can be represented in formal systems. The formal systems are to be denned as a special kind of lattice gas and they are in a form where an obvious correspondence exists between the observables in the lattice gases and the experimentally observed properties in the molecular self-assembly systems. This has the clear advantage that by using these formal systems, theory, simulation, and experiment can be conducted in concert and can mutually support each other. However, a disadvantage also exists because analytical results are difficult to obtain for these formal systems due to their inherent complexity dictated by their necessary realism. The key to novelt simpler molecules (from lower levels), dynamical hierarchies are formed [2, 3]. Dynamical hierarchies are characterized by distinct observable functionalities at multiple levels of description. Since these higher-order structures are generated spontaneously due to the physico-chemical properties of their building blocks, complexity can come for free in molecular self-assembly systems. Through such processes, matter apparently can program itself into structures that constitute living systems [11, 27, 30].

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