Synthesis of functionalised 2,3-dihydroquinolin-4(1H)-ones vs. quinoline or N-alkenylindole derivatives through sequential reactions of 2-alkynylanilines with ketones

2021 ◽  
Author(s):  
Vincenzo Marsicano ◽  
Antonio Arcadi ◽  
Marco Chiarini ◽  
Giancarlo Fabrizi ◽  
Antonella Goggiamani ◽  
...  
Keyword(s):  
Diversity Oriented Synthesis ◽  
Sequential Reactions

The diversity-oriented synthesis of 2,2,3-substituted-2,3-dihydroquinolin-4(1H)-ones vs. functionalised quinoline or N-alkenylindole derivatives is described.

A diversity-oriented synthesis of polyheterocycles via the cyclocondensation of azomethine imine

2019 ◽  
Vol 43 (35) ◽  
pp. 13721-13724 ◽  
Author(s):  
Arshad J. Ansari ◽  
Ramdas S. Pathare ◽  
Anita Kumawat ◽  
Antim K. Maurya ◽  
Sarika Verma ◽  
...  
Keyword(s):  
Diversity Oriented Synthesis ◽  
Azomethine Imine ◽  
Sequential Reactions

Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described.

Carbon Chain Growth by Sequential Reactions of CO and CO2 with a Transition Metal Carbonyl Complex

2018 ◽  
Author(s):  
Richard Kong ◽  
Mark Crimmin
Keyword(s):  
Transition Metal ◽  
Metal Carbonyl ◽  
Carbon Chain ◽  
Chain Growth ◽  
Carbonyl Complex ◽  
Fischer Tropsch ◽  
Carbon Chains ◽  
Sequential Coupling ◽  
Energy Economy ◽  
Sequential Reactions

<i>The formation of carbon chains by the coupling of COx (X = 1 or 2) units on transition metals is a fundamental step relevant to Fischer-Tropsch catalysis. Fischer-Tropsch catalysis produces energy dense liquid hydrocarbons from synthesis gas (CO and H2) and has been a mainstay of the energy economy since its discovery nearly a century ago. Despite detailed studies aimed at elucidating the steps of catalysis, experimental evidence for chain growth (Cn to Cn+1 ; n > 2) from the reaction of CO with metal complexes is unprecedented. In this paper, we show that carbon chains can be grown from sequential reactions of CO or CO2 with a transition metal carbonyl complex. By exploiting the cooperative effect of transition and main group metals, we document the first example of chain propagation from sequential coupling of CO units (C1 to C3 to C4), along with the first example of incorporation of CO2 into the growing carbon chain.</i><br>

Diversity-oriented synthesis of polymer membranes with ion solvation cages

Nature ◽  
2021 ◽  
Vol 592 (7853) ◽  
pp. 225-231
Author(s):  
Miranda J. Baran ◽  
Mark E. Carrington ◽  
Swagat Sahu ◽  
Artem Baskin ◽  
Junhua Song ◽  
...  
Keyword(s):  
Polymer Membranes ◽  
Ion Solvation ◽  
Diversity Oriented Synthesis

scholarly journals Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Akshaykumar Nayak ◽  
Himani Saxena ◽  
Chandramohan Bathula ◽  
Tarkeshwar Kumar ◽  
Souvik Bhattacharjee ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Small Molecules ◽  
New Drugs ◽  
Developmental Cycle ◽  
Oxygen Species ◽  
Compound Library ◽  
Diversity Oriented Synthesis ◽  
Resistant Strains ◽  
Acid Catalyzed

Abstract Background Despite numerous efforts to eradicate the disease, malaria continues to remain one of the most dangerous infectious diseases plaguing the world. In the absence of any effective vaccines and with emerging drug resistance in the parasite against the majority of anti-malarial drugs, the search for new drugs is urgently needed for effective malaria treatment. Methods The goal of the present study was to examine the compound library, based on indoles generated through diversity-oriented synthesis belonging to four different architecture, i.e., 1-aryltetrahydro/dihydro-β-carbolines and piperidine/pyrrolidine-fused indole derivatives, for their in vitro anti-plasmodial activity. Trifluoroacetic acid catalyzed transformation involving tryptamine and various aldehydes/ketones provided the library. Results Among all the compounds screened, 1-aryltetrahydro-β-carbolines 2 and 3 displayed significant anti-plasmodial activity against both the artemisinin-sensitive and artemisinin-resistant strain of Plasmodium falciparum. It was observed that these compounds inhibited the overall parasite growth in intra-erythrocytic developmental cycle (IDC) via reactive oxygen species-mediated parasitic death and thus could be potential anti-malarial compounds. Conclusion Overall the compounds 2 and 3 identified in this study shows promising anti-plasmodial activity that can kill both artemisinin-sensitive and artemisinin-resistant strains of P. falciparum.

Diversity-Oriented Synthesis of Tamoxifen-type Tetrasubstituted Olefins

2003 ◽  
Vol 125 (48) ◽  
pp. 14670-14671 ◽  
Author(s):  
Kenichiro Itami ◽  
Toshiyuki Kamei ◽  
Jun-ichi Yoshida
Keyword(s):  
Diversity Oriented Synthesis ◽  
Tetrasubstituted Olefins

scholarly journals Diversity-Oriented Synthesis of 3-Iodochromones and Heteroatom Analogues via ICl-Induced Cyclization.

ChemInform ◽  
2006 ◽  
Vol 37 (27) ◽  
Author(s):  
Chengxiang Zhou ◽  
Anton V. Dubrovsky ◽  
Richard C. Larock
Keyword(s):  
Diversity Oriented Synthesis

scholarly journals A Modular Reaction Pairing Approach to the Diversity-Oriented Synthesis of Fused- and Bridged-Polycyclic Sultams

2011 ◽  
Vol 13 (19) ◽  
pp. 5148-5151 ◽  
Author(s):  
Thiwanka B. Samarakoon ◽  
Joanna K. Loh ◽  
Alan Rolfe ◽  
Lisa S. Le ◽  
Sun Young Yoon ◽  
...  
Keyword(s):  
Diversity Oriented Synthesis
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