Synthesis of 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline through nucleophilic addition of organozinc reagents to N,O-acetals

2020 ◽  
Vol 18 (36) ◽  
pp. 7139-7150
Author(s):  
Rui-Jun Ma ◽  
Jian-Ting Sun ◽  
Chang-Hong Liu ◽  
Ling Chen ◽  
Chang-Mei Si ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
New Approach ◽  
Organozinc Reagents

A new approach to access 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline has been developed through nucleophilic addition of organozinc reagents to N,O-acetals.

Aldehyde group assisted thiolysis of dinitrophenyl ether: a new promising approach for efficient hydrogen sulfide probes

2014 ◽  
Vol 50 (65) ◽  
pp. 9185-9187 ◽  
Author(s):  
Zijun Huang ◽  
Shuangshuang Ding ◽  
Dehuan Yu ◽  
Feihu Huang ◽  
Guoqiang Feng
Keyword(s):  
Hydrogen Sulfide ◽  
Nucleophilic Addition ◽  
Aldehyde Group ◽  
New Approach

Combining fast nucleophilic addition of H2S to an aldehyde and thiolysis of dinitrophenyl ether, a new approach for efficient H2S probes was developed.

scholarly journals Nucleophilic Addition of Organozinc Reagents to 2-Sulfonyl Cyclic Ethers: Stereoselective Synthesis of Manassantins A and B

2009 ◽  
Vol 11 (7) ◽  
pp. 1671-1671
Author(s):  
Hyoungsu Kim ◽  
Amanda C. Kasper ◽  
Eui Jung Moon ◽  
Yongho Park ◽  
Ceshea M. Wooten ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Stereoselective Synthesis ◽  
Cyclic Ethers ◽  
Organozinc Reagents

Magnesium salt promoted tandem nucleophilic addition–Oppenauer oxidation of aldehydes with organozinc reagents

2016 ◽  
Vol 14 (41) ◽  
pp. 9720-9724 ◽  
Author(s):  
Ying Fu ◽  
Xing Ling Zhao ◽  
Hulmet Hügel ◽  
Danfeng Huang ◽  
Zhengyin Du ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Aromatic Aldehydes ◽  
Magnesium Salt ◽  
Facile Synthesis ◽  
Aromatic Ketones ◽  
Oppenauer Oxidation ◽  
Organozinc Reagents

A facile synthesis of aromatic ketones via tandem nucleophilic addition–Oppenauer oxidation of aromatic aldehydes with organozinc reagents was demonstrated. Magnesium salt in situ generated via organozinc formation is a powerful promotor for this transformation.

A New Approach for the Synthesis of 6,7-Dihydro-5H-Cyclopenta[b]pyridine

2013 ◽  
Vol 634-638 ◽  
pp. 1211-1214
Author(s):  
Jin Hua Zhou ◽  
Hai Li Gao ◽  
Han Zhou Sun ◽  
Yu Xiong Wu
Keyword(s):  
1H Nmr ◽  
Nucleophilic Addition ◽  
Raw Materials ◽  
Total Yield ◽  
Target Product ◽  
Synthetic Route ◽  
Reaction Conditions ◽  
Nmr Spectrum ◽  
New Approach ◽  
Efficient Route

A new practical and efficient route was developed for the synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine, which is a key intermediate of cefpirome. Leading to the formation of the corresponding product, nucleophilic addition, acetylization, Vilsmeier cyclization reaction and dechlorination were employed under mild reaction conditions by using commercially available cyclopentanone and benzylamine as raw materials. The total yield of this newly developed synthetic route for the target product was 43.15% with 99.7% of purity (HPLC). The structure of target molecular was confirmed by LC-MS and 1H NMR spectrum.

scholarly journals CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides

2014 ◽  
Vol 12 (25) ◽  
pp. 4295-4299 ◽  
Author(s):  
Ying Fu ◽  
Wenbo Zhu ◽  
Xingling Zhao ◽  
Helmut Hügel ◽  
Zhouqiang Wu ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Sulfonyl Chlorides ◽  
Organozinc Reagents

A general and efficient CuI/TMEDA catalyzed nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides has been developed for both aromatic and aliphatic sulfone synthesis.

Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents

2019 ◽  
Vol 84 (17) ◽  
pp. 11261-11267 ◽  
Author(s):  
Xue-Mei Wang ◽  
Yi-Wen Liu ◽  
Rui-Jun Ma ◽  
Chang-Mei Si ◽  
Bang-Guo Wei
Keyword(s):  
Nucleophilic Addition ◽  
Amino Alcohols ◽  
Organozinc Reagents

scholarly journals Managing nucleophilic addition reactions to tune the physical properties of 2-substituted pentamethylBODIPY derivatives

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 8922-8926 ◽  
Author(s):  
S. R. Sritharan ◽  
B. A. Hussein ◽  
D. D. Machin ◽  
M. A. El-Aooiti ◽  
J. A. Adjei ◽  
...  
Keyword(s):  
Physical Properties ◽  
Nucleophilic Addition ◽  
Addition Reactions ◽  
Structure Property ◽  
New Approach

A structure–property study using a new approach to electronically desymmetrize the BODIFY core.

scholarly journals Nucleophilic Addition of Organozinc Reagents to 2-Sulfonyl Cyclic Ethers: Stereoselective Synthesis of Manassantins A and B

2009 ◽  
Vol 11 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Hyoungsu Kim ◽  
Amanda C. Kasper ◽  
Eui Jung Moon ◽  
Yongho Park ◽  
Ceshea M. Wooten ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Stereoselective Synthesis ◽  
Cyclic Ethers ◽  
Organozinc Reagents
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