scholarly journals Access to a stabilized i-motif DNA structure through four successive ligation reactions on a cyclopeptide scaffold

2020 ◽  
Vol 18 (32) ◽  
pp. 6394-6406 ◽  
Author(s):  
Alexandre Devaux ◽  
Laureen Bonnat ◽  
Thomas Lavergne ◽  
Eric Defrancq
Keyword(s):  
Dna Structure ◽  
Biomolecular System

Four successive chemical ligations were used for the assembly of a sophisticated biomolecular system allowing the formation of a stabilized i-motif DNA at pH 7.

DNA Structure: What's in Charge?

2000 ◽  
Vol 304 (5) ◽  
pp. 803-820 ◽  
Author(s):  
Kevin J. McConnell ◽  
D.L. Beveridge
Keyword(s):  
Dna Structure

scholarly journals Carcinogen-induced alteration of DNA structure.

1981 ◽  
Vol 256 (9) ◽  
pp. 4504-4513 ◽  
Author(s):  
M.E. Hogan ◽  
N. Dattagupta ◽  
J.P. Whitlock
Keyword(s):  
Dna Structure

Acidic pH-responsive changes of DNA structure and surface dynamics as probed with ultrasensitive Raman spectroscopy

2021 ◽  
Vol 258 ◽  
pp. 119866
Author(s):  
Cristina M. Muntean ◽  
Nicoleta E. Dina ◽  
Ioan Bratu ◽  
Carmen Tripon ◽  
Sorina Niţu (Năstase) ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Dna Structure ◽  
Acidic Ph ◽  
Surface Dynamics ◽  
Ph Responsive

scholarly journals Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes

2020 ◽  
Vol 48 (3) ◽  
pp. 1108-1119 ◽  
Author(s):  
Rajendra Kumar ◽  
Karam Chand ◽  
Sudipta Bhowmik ◽  
Rabindra Nath Das ◽  
Snehasish Bhattacharjee ◽  
...  
Keyword(s):  
Rational Design ◽  
Dna Structure ◽  
Biological Processes ◽  
Chemical Research ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Future Studies ◽  
G4 Dna ◽  
G Quadruplex ◽  
Fluorescence Light

Abstract G-quadruplex (G4) DNA structures are linked to key biological processes and human diseases. Small molecules that target specific G4 DNA structures and signal their presence would therefore be of great value as chemical research tools with potential to further advance towards diagnostic and therapeutic developments. However, the development of these types of specific compounds remain as a great challenge. In here, we have developed a compound with ability to specifically signal a certain c-MYC G4 DNA structure through a fluorescence light-up mechanism. Despite the compound's two binding sites on the G4 DNA structure, only one of them result in the fluorescence light-up effect. This G-tetrad selectivity proved to originate from a difference in flexibility that affected the binding affinity and tilt the compound out of the planar conformation required for the fluorescence light-up mechanism. The intertwined relation between the presented factors is likely the reason for the lack of examples using rational design to develop compounds with turn-on emission that specifically target certain G4 DNA structures. However, this study shows that it is indeed possible to develop such compounds and present insights into the molecular details of specific G4 DNA recognition and signaling to advance future studies of G4 biology.

scholarly journals G-DNA: a twice-folded DNA structure adopted by single-stranded oligo(dG) and its implications for telomeres.

1990 ◽  
Vol 87 (3) ◽  
pp. 867-870 ◽  
Author(s):  
I. G. Panyutin ◽  
O. I. Kovalsky ◽  
E. I. Budowsky ◽  
R. E. Dickerson ◽  
M. E. Rikhirev ◽  
...  
Keyword(s):  
Dna Structure
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