Synthesis of N-methylated amines from acyl azides using methanol

2020 ◽  
Vol 18 (30) ◽  
pp. 5891-5896 ◽  
Author(s):  
Kaushik Chakrabarti ◽  
Kuheli Dutta ◽  
Sabuj Kundu
Keyword(s):  
One Pot ◽  
Direct Transformation ◽  
Curtius Rearrangement ◽  
Borrowing Hydrogen ◽  
Acyl Azides ◽  
The One ◽  
First Time ◽  
Methylated Amines

The Ru(ii) complex catalysed direct transformation of acyl azides into N-methylamines was developed for the first time using methanol via the one-pot Curtius rearrangement and borrowing hydrogen methodology.

scholarly journals A Simple and Efficient Method for the Partial Synthesis of Pure (3R,3’S)-Astaxanthin from (3R,3’R,6’R)-Lutein and Lutein Esters via (3R,3’S)-Zeaxanthin and Theoretical Study of Their Formation Mechanisms

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1386 ◽  
Author(s):  
Eloy Rodríguez-deLeón ◽  
J. Jiménez-Halla ◽  
José Báez ◽  
M. Bah
Keyword(s):  
Health Risks ◽  
Density Functional ◽  
Human Consumption ◽  
Formation Mechanisms ◽  
Chemical Transformations ◽  
Partial Synthesis ◽  
One Pot ◽  
Commercial Source ◽  
The One ◽  
First Time

Carotenoids are natural compounds that have important roles in promoting and maintaining human health. Synthetic astaxanthin is a highly requested product by the aquaculture industry, but natural astaxanthin is not. Various strategies have been developed to synthesize this carotenoid. Nonetheless, these approaches have not only provided limited global yields, but its main commercial source also carries several health risks for humans. In this contribution, the one-pot base-catalyzed reaction of (3R,3’R,6’R)-lutein (1) esters has resulted in a successful isomerization process to easily obtain up to 95% meso-zeaxanthin (2), which in turn is oxidized to (3R,3’S)-astaxanthin (3) with a global yield of 68%. The same oxidation performed with UV irradiation (365 nm) for 5 min provided the highest global yield (76%). These chemical transformations have also been achieved with a significant reduction of the health risks associated with its potential human consumption. Furthermore, this is the first time only one of the configurational isomers has been obtained semisynthetically. The poorly understood formation mechanisms of these two compounds were also investigated using Density-Functional Theory (DFT) calculations. These theoretical studies revealed that the isomerization involves a base-catalyzed deprotonation at C-6’, followed by C-4’ protonation, while the oxidation occurs via free radical mechanisms.

Direct Conversion of Carboxylic Acids to Various Nitrogen-Containing Compounds in the One-Pot Exploiting Curtius Rearrangement

2019 ◽  
Vol 84 (17) ◽  
pp. 11323-11334 ◽  
Author(s):  
Arun Kumar ◽  
Naveen Kumar ◽  
Ritika Sharma ◽  
Gaurav Bhargava ◽  
Dinesh Mahajan
Keyword(s):  
Carboxylic Acids ◽  
Direct Conversion ◽  
One Pot ◽  
Curtius Rearrangement ◽  
The One ◽  
Nitrogen Containing Compounds

The amino side chains do matter: chemoselectivity in the one-pot three-component synthesis of 2-amino-4H-chromenes by supramolecular catalysis with amino-appended β-cyclodextrins (ACDs) in water

2016 ◽  
Vol 6 (12) ◽  
pp. 4283-4293 ◽  
Author(s):  
Yufeng Ren ◽  
Bo Yang ◽  
Xiali Liao
Keyword(s):  
Side Chains ◽  
One Pot ◽  
Supramolecular Catalysis ◽  
The One ◽  
First Time

The one-pot three-component synthesis of 2-amino-4H-chromenes was accomplished by supramolecular catalysis with well-designed amino-appended β-cyclodextrins (ACDs) in water, while the key role of amino side chains in chemoselectivity was determined for the first time.

scholarly journals Construction of a Turn-off-on Fluorescent System Based On Aggregation Induced Emission of Acetaldehyde Using Carbonized Polymer Dots and Tb3+

2021 ◽  
Author(s):  
Rentian Guan ◽  
Shuai Zhang ◽  
Xiaoyu Fan ◽  
Xiaodong Shao ◽  
Yingying Hu ◽  
...  
Keyword(s):  
Fluorescence Enhancement ◽  
Limit Of Detection ◽  
Excitation Wavelength ◽  
Enhancement Effect ◽  
Blue Fluorescence ◽  
One Pot ◽  
Aggregation Induced Emission ◽  
Polymer Dots ◽  
The One ◽  
First Time

Abstract It was the first time to report the aggregation induced emission (AIE) of acetaldehyde (AA) on the surface of carbonized polymer dots (CPDs) with the auxiliary of Tb3+. Based on the AIE of AA, a turn-off-on fluorescence method was established for AA detection using the porous CPDs-Tb3+ system. The one-pot hydrothermal method was used to obtain CPDs, using milk and polyethyleneimine (PEI) as precursors. In the presence of Tb3+, CPDs aggregated immediately, and the fluorescence intensity decreased obviously for the precipitate. AA can effectively embed on the surface of CPDs-Tb3+ due to the porous structure. AA displayed obviously blue fluorescence with excitation wavelength at 370 nm (emission peak at 460 nm), while there was no fluorescence peak when excited at 460 nm. In the CPDs-Tb3+ solution, AA exhibits obvious fluorescence enhancement effect (lex 460 nm, lem 545 nm). And then, AA can be determined by the turn-off-on system based on the linear relationship between fluorescence enhancement and the concentration of AA ranging from 0.04 mM to 42.48 mM. The limit of detection (LOD) was 0.02 mM. The turn-off-on system was successfully applied to determine AA in wine samples. The strategy may be exploited to monitor AA in more drinking or foodstuff samples.

A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature

2021 ◽  
Author(s):  
Joaquín García-Álvarez ◽  
Vito Capriati ◽  
Luciana Cicco ◽  
Javier González-Sabín ◽  
Alejandro Presa Soto ◽  
...  
Keyword(s):  
Room Temperature ◽  
Aqueous Media ◽  
Proof Of Concept ◽  
One Pot ◽  
Tempo Oxidation ◽  
Tertiary Alcohols ◽  
Organolithium Reagents ◽  
The One ◽  
First Time ◽  
Oxidation System

The one-pot/two-step combination of enzymes and polar organometallic chemistry in aqueous media is for the first time presented as a proof-of-concept study. The unprecedented combination of the catalytic oxidation of...

scholarly journals Synthesis and Characterization of Unsymmetrical Double-Decker Siloxane (Basket Cage)

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4252 ◽  
Author(s):  
Rungthip Kunthom ◽  
Nobuhiro Takeda ◽  
Masafumi Unno
Keyword(s):  
29Si Nmr ◽  
Cage Compounds ◽  
One Pot ◽  
X Ray ◽  
X Ray Crystallography ◽  
Double Decker ◽  
Novel Structure ◽  
The One ◽  
First Time

The one-pot synthesis of an unsymmetrical double-decker siloxane with a novel structure via the reaction of double-decker tetrasodiumsilanolate with 1 equiv. of dichlorotetraphenyldisiloxane in the presence of an acid is reported herein for the first time. The target compound bearing all phenyl substituents on the unsymmetrical siloxane structure was successfully obtained, as confirmed by 1H-NMR, 13C-NMR, 29Si-NMR, IR, MALDI-TOF, and X-ray crystallography analyses. Additionally, the thermal properties of the product were evaluated by TG/DTA and compared with those of other siloxane cage compounds.

scholarly journals One-pot synthesis of vanadium-containing silica SBA-3 materials and their catalytic activity for propene oxidation

RSC Advances ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 4671-4681 ◽  
Author(s):  
Ewa Janiszewska ◽  
Agnieszka Held ◽  
Krystyna Nowińska ◽  
Stanisław Kowalak
Keyword(s):  
Catalytic Activity ◽  
One Pot ◽  
Propene Oxidation ◽  
One Pot Synthesis ◽  
The One ◽  
First Time

Efficient SBA-3 vanadosilicate catalysts for propene oxidation obtained for the first time by the one-pot synthesis.

scholarly journals Boric acid in magnetized water: clean and powerful media for synthesis of 3,4-dihydropyrimidin-2(1H)-ones

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22751-22755
Author(s):  
Vahid Khakyzadeh ◽  
Ahmad Reza Moosavi-Zare ◽  
Sahra Sheikhaleslami ◽  
Amir Ehsani ◽  
Salbin Sediqi ◽  
...  
Keyword(s):  
Magnetic Field ◽  
External Magnetic Field ◽  
Boric Acid ◽  
Condensation Reaction ◽  
One Pot ◽  
Magnetized Water ◽  
The One ◽  
First Time

Water was magnetized via an external magnetic field and employed, for the first time, as a solvent in green preparation of 3,4-dihydropyrimidin-2(1H)-ones by the one-pot three-component condensation reaction using boric acid as a catalyst.

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