Catalyst- and solvent-free efficient access to N-alkylated amines via reductive amination using HBpin

2020 ◽  
Vol 18 (20) ◽  
pp. 3853-3857
Author(s):  
Vipin K. Pandey ◽  
Somnath Bauri ◽  
Arnab Rit
Keyword(s):  
Room Temperature ◽  
Reductive Amination ◽  
Solvent Free ◽  
Secondary Amines ◽  
One Pot ◽  
Efficient Access ◽  
Wide Range ◽  
General Method

A general method for catalyst- and solvent-free room temperature reductive amination has been developed and it efficiently delivers a wide range of sterically and electronically diverse secondary amines in one-pot.

Cobalt encapsulated in N‑doped graphene sheet for one-pot reductive amination to synthesize secondary amines

2021 ◽  
Vol 505 ◽  
pp. 111504
Author(s):  
Lin Liu ◽  
Wenxiu Li ◽  
Ran Qi ◽  
Qingqing Zhu ◽  
Jing Li ◽  
...  
Keyword(s):  
Graphene Sheet ◽  
Reductive Amination ◽  
Secondary Amines ◽  
One Pot ◽  
Doped Graphene

scholarly journals Facile Synthesis of COF-Supported Reduced Pd-Based Catalyst for One-Pot Reductive Amination of Aldehydes

Catalysts ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Jianguo Liu ◽  
Mingyue Zhang ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalysts ◽  
Reductive Amination ◽  
Secondary Amines ◽  
Metallic State ◽  
One Pot ◽  
Effective Synthesis ◽  
Pharmaceutical Industries ◽  
The One ◽  
Heterocyclic Aldehydes ◽  
Supported Pd

Dibenzylamine motifs are an important class of crucial organic compounds and are widely used in fine chemical and pharmaceutical industries. The development of the efficient, economical, and environmentally friendly synthesis of amines using transition metal-based heterogeneous catalysts remains both desirable and challenging. Herein, we prepared the covalent organic framework (COF)-supported heterogeneous reduced COF-supported Pd-based catalyst and used it for the one-pot reductive amination of aldehydes. There are both Pd metallic state and oxidated Pdσ+ in the catalysts. Furthermore, in the presence of the reduced COF-supported Pd-based catalyst, many aromatic, aliphatic, and heterocyclic aldehydes with various functional groups substituted were converted to their corresponding amines products in good to excellent selectivity (up to 91%) under mild reaction conditions (70 °C, 2 h, NH3, 20 bar H2). This work expands the covalent organic frameworks for the material family and its support catalyst, opening up new catalytic applications in the economical, practical, and effective synthesis of secondary amines.

Direct reductive amination of aldehydes using lithium-arene(cat.) as reducing system. A simple one-pot procedure for the synthesis of secondary amines

2012 ◽  
Vol 53 (25) ◽  
pp. 3156-3160 ◽  
Author(s):  
Fabiana Nador ◽  
Yanina Moglie ◽  
Andrés Ciolino ◽  
Adriana Pierini ◽  
Viviana Dorn ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Secondary Amines ◽  
One Pot ◽  
System A

Alkene Difunctionalization Directed by Free Amines: Diamine Synthesis via Nickel-Catalyzed 1,2-Carboamination

2021 ◽  
Author(s):  
Taeho Kang ◽  
José Manuel González ◽  
Zi-Qi Li ◽  
Klement Foo ◽  
Peter Cheng ◽  
...  
Keyword(s):  
Nickel Catalyst ◽  
Room Temperature ◽  
Kinetic Studies ◽  
Fine Tuning ◽  
Secondary Amines ◽  
Protecting Group ◽  
Wide Range ◽  
Leaving Group ◽  
Primary And Secondary Amines ◽  
Reaction Proceeds

A versatile method to access differentially substituted 1,3- and 1,4-diamines via a nickel-catalyzed three-component 1,2-carboamination of alkenyl amines with aryl/alkenylboronic ester nucleophiles and N–O electrophiles is reported. The reaction proceeds efficiently with free primary and secondary amines without needing a directing auxiliary or protecting group, and is enabled by fine-tuning the leaving group on the N–O reagent. The transformation is highly regioselective and compatible with a wide range of coupling partners and alkenyl amine substrates, all performed at room temperature. A series of kinetic studies support a mechanism in which alkene coordination to the nickel catalyst is turnover-limiting.

Intermetallic Ni2Si/SiCN as a highly efficient catalyst for the one-pot tandem synthesis of imines and secondary amines

2020 ◽  
Vol 7 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Xiao Chen ◽  
Shuhua Han ◽  
Dongdong Yin ◽  
Changhai Liang
Keyword(s):  
High Activity ◽  
Aromatic Amine ◽  
Reductive Amination ◽  
High Selectivity ◽  
Secondary Amines ◽  
One Pot ◽  
Efficient Catalyst ◽  
Highly Efficient ◽  
The One ◽  
Tandem Synthesis

For the one-pot reductive amination of benzaldehyde with nitrobenzene, intermetallic Ni2Si/SiCN from the decomposition of a nickel-modified polysilazane precursor exhibited high activity (>99%) and high selectivity (92% to aromatic amine).

One-pot, chemoselective synthesis of secondary amines from aryl nitriles using a PdPt–Fe3O4 nanoparticle catalyst

2020 ◽  
Vol 10 (13) ◽  
pp. 4201-4209
Author(s):  
Jin Hee Cho ◽  
Sangmoon Byun ◽  
Ahra Cho ◽  
B. Moon Kim
Keyword(s):  
Reductive Amination ◽  
Secondary Amines ◽  
Fe3o4 Nanoparticle ◽  
Catalytic Method ◽  
One Pot ◽  
Chemoselective Synthesis ◽  
Aryl Nitriles ◽  
The One ◽  
Nanoparticle Catalyst

We have developed a new catalytic method for the one-pot, cascade synthesis of unsymmetrical secondary amines via the reductive amination of aryl nitriles with nitroalkanes using a PdPt–Fe3O4 nanoparticle (NP) catalyst.

scholarly journals A Facile Solvent-Free Route for One-Pot Multicomponent Synthesis of Benzylpyrazolyl Coumarins Derivatives in Presence of Effective Synergetic Catalytic System

2019 ◽  
Vol 31 (6) ◽  
pp. 1357-1361 ◽  
Author(s):  
NARENDRA R. KAMBLE ◽  
VINOD T. KAMBLE
Keyword(s):  
Room Temperature ◽  
Silver Salt ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Niobium Pentachloride ◽  
Solvent Free Conditions ◽  
Work Up ◽  
Solvent Free Reaction

A combinatorial library of benzylpyrazolyl coumarin derivatives have been synthesized by a green one-pot four-component reaction between aryl hydrazine/hydrazine hydrate (1), ethyl acetoacetate (2), aromatic aldehydes (3) and 4-hydroxycoumarin (4) catalyzed by niobium pentachloride with silver salt under solvent-free conditions has been developed. Experimental simplicity, simple work-up procedure and solvent-free reaction condition at room temperature are important features of the present protocol.

Mandelic acid catalyzed one-pot three-component synthesis of α-aminonitriles and α-aminophosphonates under solvent-free conditions at room temperature

2020 ◽  
Vol 50 (10) ◽  
pp. 1545-1560 ◽  
Author(s):  
Gurpreet Kaur ◽  
Mussarat Shamim ◽  
Vaishali Bhardwaj ◽  
Vivek Kumar Gupta ◽  
Bubun Banerjee
Keyword(s):  
Mandelic Acid ◽  
Room Temperature ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Acid Catalyzed
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