scholarly journals Synthesis and evaluation of Nα,Nε-diacetyl-l-lysine-inositol conjugates as cancer-selective probes for metabolic engineering of GPIs and GPI-anchored proteins

2020 ◽  
Vol 18 (15) ◽  
pp. 2938-2948 ◽  
Author(s):  
Mohit Jaiswal ◽  
Sanyong Zhu ◽  
Wenjie Jiang ◽  
Zhongwu Guo
Keyword(s):  
Metabolic Engineering ◽  
Cancer Cells ◽  
Cancer Targeting ◽  
Metabolic Labeling ◽  
Molecular Tools ◽  
New Strategy

This study has established a new strategy and new molecular tools for selective metabolic labeling of inositol on cancer cells, which should be useful for cancer targeting and study of GPI-anchored proteins.

Panax Notoginseng Saponins Promote Cell Death and Chemosensitivity in Pancreatic Cancer through the Apoptosis and Autophagy Pathways

2020 ◽  
Vol 20 ◽  
Author(s):  
Li-Chao Yao ◽  
Lun Wu ◽  
Wei Wang ◽  
Lu-Lu Zhai ◽  
Lin Ye ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Panax Notoginseng ◽  
Panax Notoginseng Saponins ◽  
Transwell Assay ◽  
Pancreatic Cancer Cells ◽  
New Strategy ◽  
Induced Apoptosis ◽  
Promote Cell Death

Background:: Panax Notoginseng Saponins (PNS) is used as traditional Chinese medicine for ischemic stroke and cardiovascular disease, it has been proven to possess anticancer activity recently. Objective:: In this study, we aimed to explore the anticancer curative effect and potential mechanisms of PNS in pancreatic cancer cells. Methods:: Pancreatic cancer Miapaca2 and PANC-1 cells were treated with PNS and Gemcitabine (Gem), respectively. Then the cell viability was assessed by CCK-8 assay, cell proliferation was tested by colony formation assay and EdU cell proliferation assay, cell migration and invasiveness were tested by wound healing assay and transwell assay respectively, and cell apoptosis was detected by flow cytometry. Finally, we detected the expression levels of proteins related to migration, apoptosis and autophagy through Western blotting. Results:: PNS not only inhibited the proliferation, migration, invasion and autophagy of Miapaca2 and PANC-1 cells, but also induced apoptosis and promoted chemosensitivity of pancreatic cancer cells to Gem. Conclusion:: PNS may exhibit cytotoxicity and increase chemosensitivity of pancreatic cancer cells to Gem by inhibiting autophagy and inducing apoptosis, providing a new strategy and potential treatment option for pancreatic cancer.

scholarly journals Development of a bispecific immune engager using a recombinant malaria protein

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Mie A. Nordmaj ◽  
Morgan E. Roberts ◽  
Emilie S. Sachse ◽  
Robert Dagil ◽  
Anne Poder Andersen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Immune Evasion ◽  
Blood Cells ◽  
Xenograft Model ◽  
Cancer Targeting ◽  
Single Chain Variable Fragment ◽  
Single Chain ◽  
Conjugation System ◽  
Immune Mediated

AbstractAs an immune evasion and survival strategy, the Plasmodium falciparum malaria parasite has evolved a protein named VAR2CSA. This protein mediates sequestration of infected red blood cells in the placenta through the interaction with a unique carbohydrate abundantly and exclusively present in the placenta. Cancer cells were found to share the same expression of this distinct carbohydrate, termed oncofetal chondroitin sulfate on their surface. In this study we have used a protein conjugation system to produce a bispecific immune engager, V-aCD3, based on recombinant VAR2CSA as the cancer targeting moiety and an anti-CD3 single-chain variable fragment linked to a single-chain Fc as the immune engager. Conjugation of these two proteins resulted in a single functional moiety that induced immune mediated killing of a broad range of cancer cells in vitro and facilitated tumor arrest in an orthotopic bladder cancer xenograft model.

X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14627-14634 ◽  
Author(s):  
Fang Liu ◽  
Junzhe Lou ◽  
Dimitre Hristov
Keyword(s):  
Cancer Cells ◽  
Cell Nucleus ◽  
Reactive Nitrogen Species ◽  
Nitrogen Species ◽  
Triggered Release ◽  
X Ray ◽  
Enhanced Sensitivity ◽  
New Strategy ◽  
Targeting Peptide

New strategy to enhance cancer radiotherapy: A novel gold nanosystem with surface-grafted nitroimidazole and cell nucleus-targeting peptide achieves the release of a RNS precursor, nitrite, by ionizing radiation. In vitro radiotherapy shows enhanced sensitivity of hypoxic cancer cells to X-ray radiation, presumably due to the generation of both reactive oxygen and nitrogen species.

A New Nanorobots Movement Control Strategy for Treating Cancer

2021 ◽  
Vol 12 (4) ◽  
pp. 149-163
Author(s):  
Doaa Ezzat ◽  
Safaa El-Sayed Amin ◽  
Howida A. Shedeed ◽  
Mohamed F. Tolba
Keyword(s):  
Fuzzy Logic ◽  
Cancer Cells ◽  
Control Strategy ◽  
Blood Cells ◽  
Movement Control ◽  
Simulation Experiments ◽  
Swarm Optimization ◽  
New Strategy ◽  
Dynamic Obstacle Avoidance ◽  
Dynamic Obstacle

Nanorobots were proposed to deliver drugs directly into cancer cells to destroy only these cells without harming the surrounding cells. During their journey, the nanorobots may encounter some obstacles such as blood cells which may be resistant to their movement. So, it is necessary to avoid collisions with these obstacles to achieve their goal. This study proposes a new strategy for controlling the nanorobots movement in human body to reach cancer cells. This proposed strategy uses an efficient algorithm based on fuzzy logic for dynamic obstacle avoidance. Also, this proposed strategy uses the directed particle swarm optimization (DPSO) algorithm for delivering nanorobots to cancer cells. Simulation experiments have proved that the proposed control strategy can efficiently deliver nanorobots to their target and also avoid collisions with dynamic obstacles which move in the same direction of the nanorobots or across their direction.

Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation

2016 ◽  
Vol 52 (5) ◽  
pp. 966-969 ◽  
Author(s):  
Deepanjali Gurav ◽  
Oommen P. Varghese ◽  
Osama A. Hamad ◽  
Bo Nilsson ◽  
Jöns Hilborn ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Multidrug Resistance ◽  
Chondroitin Sulfate ◽  
Cancer Cells ◽  
Chemotherapeutic Drug ◽  
New Strategy

We have developed the first chondroitin sulfate polymer coated gold nanoparticles that can simultaneously overcome mulidrug resistance in cancer cells and suppress thromboinflammation triggered by the chemotherapeutic drug.

scholarly journals Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 301 ◽  
Author(s):  
Kim ◽  
Choi ◽  
Choi ◽  
Park ◽  
Ryu
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Colloidal Stability ◽  
Inorganic Nanoparticles ◽  
Cancer Targeting ◽  
Anionic Polymer ◽  
Enhanced Permeability And Retention ◽  
Interaction With Receptors

Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, and nanoparticles) can be prepared easily using assembly and modification of its functional groups such as carboxy, hydroxy and N-acetyl groups. Nanometer-sized HA nanomedicines can selectively deliver drugs or other molecules into tumor sites via their enhanced permeability and retention (EPR) effect. In addition, HA can interact with overexpressed receptors in cancer cells such as cluster determinant 44 (CD44) and receptor for HA-mediated motility (RHAMM) and be degraded by a family of enzymes called hyaluronidase (HAdase) to release drugs or molecules. By interaction with receptors or degradation by enzymes inside cancer cells, HA nanomedicines allow enhanced targeting cancer therapy. In this article, recent studies about HA nanomedicines in drug delivery systems, photothermal therapy, photodynamic therapy, diagnostics (because of the high biocompatibility), colloidal stability, and cancer targeting are reviewed for strategies using micelles, nanogels, and inorganic nanoparticles.

scholarly journals A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells

2016 ◽  
Vol 145 ◽  
pp. 91-102 ◽  
Author(s):  
Razan Sheta ◽  
Christina M. Woo ◽  
Florence Roux-Dalvai ◽  
Frédéric Fournier ◽  
Sylvie Bourassa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Metabolic Labeling ◽  
Labeling Approach

A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10071-10077 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Ning Ma ◽  
Ren-Xi Zhuo ◽  
Xian-Zheng Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Self Assembly ◽  
Silica Nanoparticle ◽  
Cancer Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Amphiphilic Peptides ◽  
Redox Responsive

A novel redox-responsive mesoporous silica nanoparticle (RRMSN/DOX) capped with amphiphilic peptides by self-assembly was demonstrated for targeting drug delivery in cancer cells.

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