Mechanochemical properties of DNA origami nanosprings revealed by force jumps in optical tweezers

Nanoscale ◽  
2021 ◽  
Author(s):  
Deepak Karna ◽  
Wei Pan ◽  
Shankar Pandey ◽  
Yuki Suzuki ◽  
Hanbin Mao
Keyword(s):  
Optical Tweezers ◽  
Dna Origami ◽  
Spring Constants

Using a force-jump approach in optical tweezers, the spring constants and dynamic recoiling responses of DNA nanosprings can be recorded.

scholarly journals Microchemomechanical devices using DNA hybridization

2021 ◽  
Vol 118 (21) ◽  
pp. e2023508118
Author(s):  
Guolong Zhu ◽  
Mark Hannel ◽  
Ruojie Sha ◽  
Feng Zhou ◽  
Matan Yah Ben Zion ◽  
...  
Keyword(s):  
Optical Tweezers ◽  
Dna Hybridization ◽  
Mechanical Energy ◽  
Dna Nanotechnology ◽  
Dna Origami ◽  
Force Extension ◽  
Dna Oligonucleotides ◽  
Time Space ◽  
Holographic Optical Tweezers ◽  
Micromechanical Devices

The programmability of DNA oligonucleotides has led to sophisticated DNA nanotechnology and considerable research on DNA nanomachines powered by DNA hybridization. Here, we investigate an extension of this technology to the micrometer-colloidal scale, in which observations and measurements can be made in real time/space using optical microscopy and holographic optical tweezers. We use semirigid DNA origami structures, hinges with mechanical advantage, self-assembled into a nine-hinge, accordion-like chemomechanical device, with one end anchored to a substrate and a colloidal bead attached to the other end. Pulling the bead converts the mechanical energy into chemical energy stored by unzipping the DNA that bridges the hinge. Releasing the bead returns this energy in rapid (>20 μm/s) motion of the bead. Force-extension curves yield energy storage/retrieval in these devices that is very high. We also demonstrate remote activation and sensing—pulling the bead enables binding at a distant site. This work opens the door to easily designed and constructed micromechanical devices that bridge the molecular and colloidal/cellular scales.

Defining the trapping limits of holographical optical tweezers

2004 ◽  
Vol 51 (3) ◽  
pp. 409-414 ◽  
Author(s):  
P. Jordan ◽  
J. Leach ◽  
M. J. Padgett ◽  
J. Cooper ◽  
G. Sinclair
Keyword(s):  
Optical Tweezers

Recent Developments of New DNA Origami Nanostructures for Drug Delivery

2015 ◽  
Vol 21 (22) ◽  
pp. 3181-3190 ◽  
Author(s):  
Juan Yan ◽  
Chongya Hu ◽  
Xunwei Liu ◽  
Jian Zhong ◽  
Gang Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Origami ◽  
Recent Developments

Electromagnetic-matter interactions and devices

2017 ◽  
Author(s):  
Sandip Tiwari
Keyword(s):  
Optical Tweezers ◽  
Quantum Cascade Lasers ◽  
Accelerator Physics ◽  
X Ray ◽  
Quantum Cascade ◽  
Inorganic Systems ◽  
Charge Cloud ◽  
Atomic Distance ◽  
Extinction Length ◽  
Cascade Lasers

This chapter explores electromagnetic-matter interactions from photon to extinction length scales, i.e., nanometer of X-ray and above. Starting with Casimir-Polder effect to understand interactions of metals and dielectrics at near-atomic distance scale, it stretches to larger wavelengths to explore optomechanics and its ability for energy exchange and signal transduction between PHz and GHz. This range is explored with near-quantum sensitivity limits. The chapter also develops the understanding phononic bandgaps, and for photons, it explores the use of energetic coupling for useful devices such as optical tweezers, confocal microscopes and atomic clocks. It also explores miniature accelerators as a frontier area in accelerator physics. Plasmonics—the electromagnetic interaction with electron charge cloud—is explored for propagating and confined conditions together with the approaches’ possible uses. Optoelectronic energy conversion is analyzed in organic and inorganic systems, with their underlying interaction physics through solar cells and its thermodynamic limit, and quantum cascade lasers.

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