A pH/ultrasonic dual-response step-targeting enterosoluble granule for combined sonodynamic-chemotherapy guided via gastrointestinal tract imaging in orthotopic colorectal cancer

Nanoscale ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 4278-4294
Author(s):  
Ruo-Yun Zhang ◽  
Kai Cheng ◽  
Yang Xuan ◽  
Xiao-Quan Yang ◽  
Jie An ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Novel Approach ◽  
Dual Response ◽  
Controlled Released

In this paper, a new pH/US step-targeting precisely controlled-released system with oral administration is designed for a combined sonodynamic-chemotherapy providing a novel approach for the theranostics of orthotopic colorectal cancer.

A novel approach to ameliorate experimental milk allergy based on the oral administration of a short soy cross-reactive peptide

2020 ◽  
pp. 128926
Author(s):  
Ángela María Candreva ◽  
Paola L. Smaldini ◽  
Ana Cauerhff ◽  
Silvana Petruccelli ◽  
Guillermo H. Docena
Keyword(s):  
Oral Administration ◽  
Milk Allergy ◽  
Novel Approach

scholarly journals HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Dan Song ◽  
Ming Guo ◽  
Shuai Xu ◽  
Xiaotian Song ◽  
Bin Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Intellectual Development ◽  
Molecular Mechanisms ◽  
Hsp90 Inhibitor ◽  
Pseudouridine Synthase ◽  
Novel Approach ◽  
Cell Metastasis ◽  
Underlying Mechanisms

Abstract Background Pseudouridine synthase (PUS) 7 is a member of the PUS family that catalyses pseudouridine formation. It has been shown to be involved in intellectual development and haematological malignancies. Nevertheless, the role and the underlying molecular mechanisms of PUS7 in solid tumours, such as colorectal cancer (CRC), remain unexplored. This study elucidated, for the first time, the role of PUS7 in CRC cell metastasis and the underlying mechanisms. Methods We conducted immunohistochemistry, qPCR, and western blotting to quantify the expression of PUS7 in CRC tissues as well as cell lines. Besides, diverse in vivo and in vitro functional tests were employed to establish the function of PUS7 in CRC. RNA-seq and proteome profiling analysis were also applied to identify the targets of PUS7. PUS7-interacting proteins were further uncovered using immunoprecipitation and mass spectrometry. Results Overexpression of PUS7 was observed in CRC tissues and was linked to advanced clinical stages and shorter overall survival. PUS7 silencing effectively repressed CRC cell metastasis, while its upregulation promoted metastasis, independently of the PUS7 catalytic activity. LASP1 was identified as a downstream effector of PUS7. Forced LASP1 expression abolished the metastasis suppression triggered by PUS7 silencing. Furthermore, HSP90 was identified as a client protein of PUS7, associated with the increased PUS7 abundance in CRC. NMS-E973, a specific HSP90 inhibitor, also showed higher anti-metastatic activity when combined with PUS7 repression. Importantly, in line with these results, in human CRC tissues, the expression of PUS7 was positively linked to the expression of HSP90 and LASP1, and patients co-expressing HSP90/PUS7/LASP1 showed a worse prognosis. Conclusions The HSP90-dependent PUS7 upregulation promotes CRC cell metastasis via the regulation of LASP1. Thus, targeting the HSP90/PUS7/LASP1 axis may be a novel approach for the treatment of CRC.

scholarly journals A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2428
Author(s):  
Małgorzata Guz ◽  
Witold Jeleniewicz ◽  
Anna Malm ◽  
Izabela Korona-Glowniak
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Current Knowledge ◽  
Vital Role ◽  
Disease States ◽  
Health And Disease ◽  
Dietary Components ◽  
Non Coding Rnas

A still growing interest between human nutrition in relation to health and disease states can be observed. Dietary components shape the composition of microbiota colonizing our gastrointestinal tract which play a vital role in maintaining human health. There is a strong evidence that diet, gut microbiota and their metabolites significantly influence our epigenome, particularly through the modulation of microRNAs. These group of small non-coding RNAs maintain cellular homeostasis, however any changes leading to impaired expression of miRNAs contribute to the development of different pathologies, including neoplastic diseases. Imbalance of intestinal microbiota due to diet is primary associated with the development of colorectal cancer as well as other types of cancers. In the present work we summarize current knowledge with particular emphasis on diet-microbiota-miRNAs axis and its relation to the development of colorectal cancer.

Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets

Amino Acids ◽  
2013 ◽  
Vol 45 (5) ◽  
pp. 1169-1177 ◽  
Author(s):  
Jun Zhang ◽  
Yulong Yin ◽  
Xu Gang Shu ◽  
Tiejun Li ◽  
Fengna Li ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Glutamate Receptors

scholarly journals Case Report: Carcinoma of Colon

2018 ◽  
Vol 4 (1) ◽  
pp. 1-3
Author(s):  
sushila ladumor ◽  
Adham Darweesh
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
Survival Rate ◽  
Gastrointestinal Tract ◽  
Colorectal Carcinoma ◽  
Surgical Resection ◽  
Early Stage ◽  
Occult Lesion ◽  
Carcinoma Of Colon ◽  
Ct And Mri

Colorectal cancer is a disease that is curable if diagnosed at early stage and also it is preventable if predisposing adenomas are detected and removed. Colorectal Carcinoma (CRC) is commonest malignancy of the gastrointestinal tract and is the second most usually diagnosed cancer in adults, mainly at 6th to 7th decades of life[2]. CT and MRI are the modalities of choice used for staging. Colonoscopy for better evaluation and tissue diagnosis as well as to see other occult lesion. Surgical resection may be curative although five-year survival rate is 40 - 50 %.

Cancers of the gastrointestinal tract

2010 ◽  
pp. 2405-2416
Author(s):  
J.A. Bridgewater ◽  
S.P. Pereira
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Targeted Therapies ◽  
Translational Medicine ◽  
Genetic Mechanisms

Cancers of the gastrointestinal tract are one of the most rewarding interfaces in translational medicine—particularly on colorectal cancer—leading to greater understanding of the genetic mechanisms leading to cancer and the development of novel targeted therapies. Diagnosis of gastrointestinal tract cancers is usually made or suspected at endoscopy, confirmed by biopsy....

scholarly journals Prediction of Oral Absorption of Low-Solubility Drugs by Using Rat Simulated Gastrointestinal Fluids: The Importance of Regional Differences in Membrane Permeability and Solubility

2014 ◽  
Vol 17 (1) ◽  
pp. 106 ◽  
Author(s):  
Yusuke Tanaka ◽  
Toshiyuki Baba ◽  
Koji Tagawa ◽  
Ryoichi Waki ◽  
Shunji Nagata
Keyword(s):  
Oral Administration ◽  
Regional Differences ◽  
Oral Absorption ◽  
Aqueous Solubility ◽  
Oral Drug ◽  
Novel Approach ◽  
Low Solubility ◽  
Low Solubility Drugs ◽  
Saturated Solubility

Purpose. This study aimed to develop a novel approach for predicting the oral absorption of low-solubility drugs by considering regional differences in solubility and permeability within the gastrointestinal (GI) tract. Methods. Simulated GI fluids were prepared to reflect rat in vivo bile acid and phospholipid concentrations in the upper and lower small intestine. The saturated solubility and permeability of griseofulvin (GF) and albendazole (AZ), a drug with low aqueous solubility, were measured using these simulated fluids, and fraction absorbed (Fa) at time t after oral administration was calculated. Results. The saturated solubility of GF and AZ, a drug with low aqueous solubility, differed considerably between the simulated GI fluids. Large regional differences in drugs concentration were also observed following oral administration in vivo. The predicted Fa values using solubility and permeability data of the simulated GI fluid were found to correspond closely to the in vivo data. Conclusion. These results indicated the importance of evaluating regional differences in drug solubility and permeability in order to predict oral absorption of low-solubility drugs accurately. The new methodology developed in the present study could be useful for new oral drug development. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Large Bowel Endometriosis Mimicking Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Laís Marques Mota ◽  
Bruno Salomão Hirsch ◽  
Renato Seligman
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Human Body ◽  
Large Bowel ◽  
Surgical Intervention ◽  
Endometrial Tissue ◽  
Differential Diagnoses ◽  
Diagnostic Challenge ◽  
Female Population ◽  
Bowel Endometriosis

Endometriosis is characterized by the presence of endometrial tissue outside the uterus, with 1–7% prevalence in the female population. It is observed in various locations of the human body, and large bowel endometriosis is the most common extrapelvic site, affecting about 5 to 12% of all women who present endometriosis. This study aimed to report an interesting images related to stenosing large bowel endometriosis that was possible to be diagnosed only by surgical intervention. Hence, this pathology is a diagnostic challenge and should be remembered between differential diagnoses of nonspecific or even alarming symptoms of the gastrointestinal tract.

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