scholarly journals Stiffening of DU145 Prostate Cancer Cells Driven by Actin Filaments – Microtubules Crosstalk Conferring Resistance to Microtubule-Targeting Drugs

Nanoscale ◽  
2021 ◽  
Author(s):  
Andrzej Kubiak ◽  
matteo chighizola ◽  
Carsten Schulte ◽  
Natalia Bryniarska ◽  
Julita Wesołowska ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Actin Filaments ◽  
Crucial Role ◽  
Prostate Cancer Cells ◽  
Segregation Of Chromosomes

The crucial role of microtubules in the mitotic-related segregation of chromosomes makes them an excellent target for anticancer microtubule targeting drugs (MTDs) such as, e.g., vinflunine (VFL), colchicine (COL), and...

scholarly journals Stiffening of prostate cancer cells driven by actin filaments – microtubules crosstalk confers resistance to microtubule-targeting drugs

2020 ◽  
Author(s):  
Andrzej Kubiak ◽  
Matteo Chighizola ◽  
Carsten Schulte ◽  
Natalia Bryniarska ◽  
Julita Wesołowska ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Actin Filaments ◽  
Biomechanical Properties ◽  
Living Cells ◽  
Prostate Cancer Cells ◽  
Force Microscopy ◽  
Atomic Force ◽  
Segregation Of Chromosomes

AbstractThe crucial role of microtubules in the mitotic-related segregation of chromosomes makes them an excellent target for anticancer microtubule targeting drugs (MTDs) such as vinflunine, colchicine, and docetaxel. MTDs affect mitosis by directly perturbing the structural organization of microtubules. By a direct assessment of the biomechanical properties of prostate cancer cells exposed to different MTDs using atomic force microscopy, we show that cell stiffening is a candidate mechanism through which cancer cells preserve the original phenotype in response to the application of MTDs. While changes in cellular rigidity are typically mainly attributed to remodeling of the actin filaments in the cytoskeleton, here we provide evidence that cell stiffening can be driven by a crosstalk between actin filaments and microtubules in drug-treated cells. Our findings improve the interpretation of biomechanical data obtained for living cells in studies of various physiological and pathological processes.

scholarly journals Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G1 to S Phase

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56692 ◽  
Author(s):  
Shalini Murthy ◽  
Min Wu ◽  
V. Uma Bai ◽  
Zizheng Hou ◽  
Mani Menon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells

scholarly journals Role of WNT5A receptors FZD5 and RYK in prostate cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (43) ◽  
pp. 27293-27304 ◽  
Author(s):  
Stefanie Thiele ◽  
Ariane Zimmer ◽  
Andy Göbel ◽  
Tilman D. Rachner ◽  
Sandra Rother ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells

scholarly journals The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells

2021 ◽  
Author(s):  
Merve Nur İNCE ◽  
Asuman DEVECİ ÖZKAN ◽  
Erhan BEZDEGÜMELİ ◽  
Ahmet Yasir MEN ◽  
Bilge Nur KÜÇÜKAKÇA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Toll Like Receptor ◽  
Prostate Cancer Cells

Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells

2009 ◽  
Vol 7 (11) ◽  
pp. 1745-1755 ◽  
Author(s):  
Geraldine Gueron ◽  
Adriana De Siervi ◽  
Mercedes Ferrando ◽  
Marcelo Salierno ◽  
Paola De Luca ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Critical Role ◽  
Heme Oxygenase 1 ◽  
Prostate Cancer Cells ◽  
Invasive Potential
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